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ALOXE3

Official Full Name

arachidonate lipoxygenase 3
Overview

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

ALOXE3; arachidonate lipoxygenase 3; epidermis-type lipoxygenase 3; E LOX; eLOX3; e LOX 3; e-LOX-3; Epidermal lipoxygenase; Lipoxygenase 3; LOXE3_HUMAN; E-LOX;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ALOXE3-489H	Recombinant Human ALOXE3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ALOXE3-8895HCL	Recombinant Human ALOXE3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ALOXE3-1485HF	Recombinant Full Length Human ALOXE3 Protein, GST-tagged	In Vitro Cell Free System	GST	711 amino acids	Inquiry
Rat	ALOXE3-640R	Recombinant Rat ALOXE3 Protein	Mammalian Cell	His		Inquiry
Rat	ALOXE3-296R	Recombinant Rat ALOXE3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ALOXE3-296R-B	Recombinant Rat ALOXE3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

ALOXE3 involved in several pathways and played different roles in them. We selected most pathways ALOXE3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOXE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

ALOXE3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ALOXE3 itself. We selected most functions ALOXE3 had, and list some proteins which have the same functions with ALOXE3. You can find most of the proteins on our site.

Function	Related Protein

ALOXE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOXE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOXE3.