ANK1 Protein, ankyrin 1, erythrocytic


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Official Full Name ankyrin 1, erythrocytic
Background Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
Synonyms ANK1; ankyrin 1, erythrocytic; ANK; ankyrin-1; SPH1; ANK-1; ANK1_HUMAN; Ankyrin 1; Ankyrin R; Ankyrin-R; Erythrocyte ankyrin; SPH2
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ANK1-1730H Recombinant Human ANK1 protein, His & T7-tagged E.coli His/T7
    Human ANK1-3490H Recombinant Human ANK1, His-tagged E.Coli or Yeast His
    Human ANK1-561H Recombinant Human ANK1 protein, GST-tagged Wheat Germ GST
    Human ANK1-75HCL Recombinant Human ANK1 cell lysate N/A
    Mouse ANK1-1644M Recombinant Mouse ANK1 Protein Mammalian Cell His

    ANK1 involved in several pathways and played different roles in them. We selected most pathways ANK1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer CCND1; FLNA; ROCK1; FZD7; MAPK12; PIK3R1; MAPK13; FGF2; FASLG; FZD8

    ANK1 has several biochemical functions, for example, ATPase binding, cytoskeletal adaptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANK1 itself. We selected most functions ANK1 had, and list some proteins which have the same functions with ANK1. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ESR1; ATP6V0A2; SDF2L1; PKD2; SYVN1; ATP1B1; SLN; ZNHIT6; CHRNA7; DNAJC10
    cytoskeletal adaptor activity NCK1; GAS2L2; NCK2; BAIAP2L1B; BIN3; BAIAP2L1; BAIAP2L2; BAIAP2L2B; SDCBP; BAIAP2L1A
    enzyme binding PPARG; CTNNB1; BCL10; AXIN2; PICK1; PRTN3; SUPT5H; LGALS9; MAT2B; BLZF1
    protein binding ZNF572; METTL17; AGBL4; SLX1B; PARP1; VPS28; FSTL1; OSR2; MLST8; OPA1
    spectrin binding EPB41; ADD2; SLC26A5; CAMSAP1; EPB49; USH1G; UNC13A; CAMSAP1L1; USH1C; ADD1
    structural constituent of cytoskeleton ARPC4; TPM1; VIM; ACTR2; KRT14; CTNNA2; TUBA1B; ADD3; TUBA4L; DSP
    structural molecule activity CLDN3; KRT35; CLTB; ANXA1; KRTAP11-1; SNTA1; KRTAP3-1; PLP1; KRT80; KRT8

    ANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK1.


    Hughes, MR; Anderson, N; et al. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. EXPERIMENTAL HEMATOLOGY 39:305-320(2011).
    Giacomello, E; Sorrentino, V; et al. Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres. HISTOCHEMISTRY AND CELL BIOLOGY 131:371-382(2009).

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