Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ANK1

  • Official Full Name

    ankyrin 1, erythrocytic

  • Overview

    Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
  • Synonyms

    ANK1; ankyrin 1, erythrocytic; ANK; ankyrin-1; SPH1; ANK-1; ANK1_HUMAN; Ankyrin 1; Ankyrin R; Ankyrin-R; Erythrocyte ankyrin; SPH2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANK1-3490H Recombinant Human ANK1, His-tagged E.Coli or Yeast His 1880
Human ANK1-1730H Recombinant Human ANK1 protein, His & T7-tagged E.coli His/T7 Leu32~Leu369 (Accession # P16157)
Human ANK1-561H Recombinant Human ANK1 protein, GST-tagged Wheat Germ GST
Human ANK1-75HCL Recombinant Human ANK1 cell lysate N/A
Human ANK1-1012HF Recombinant Full Length Human ANK1 Protein, GST-tagged In Vitro Cell Free System GST 155 amino acids
Mouse ANK1-1644M Recombinant Mouse ANK1 Protein Mammalian Cell His
Mouse ANK1-532M Recombinant Mouse ANK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ANK1-532M-B Recombinant Mouse ANK1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANK1 Related Articles

ANK1 involved in several pathways and played different roles in them. We selected most pathways ANK1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerCasp3;PIK3R1;TLR2;WNT3;TRP53;WNT5A;FZD3;HSPB2;ERBB3

ANK1 has several biochemical functions, for example, ATPase binding, cytoskeletal adaptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANK1 itself. We selected most functions ANK1 had, and list some proteins which have the same functions with ANK1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATPIF1;TAF9;BBC3;RALB;ATP6V0A1B;FBL;TCIRG1;FXYD1;CAV1
cytoskeletal adaptor activityGAS2L2;BAIAP2;BAIAP2L2;ABI2;SDCBP;BICD1;BIN3;BAIAP2L2B;NCK1
enzyme bindingWWOX;USP22;DAOA;MAT2B;UGT1A9;RYR2;RCOR2;EHHADH;VAPB
protein bindingDACT1;ADIPOQ;PDE3B;SATB1;ARHGAP4;VPS11;CAV2;INPP5B;CCBE1
spectrin bindingPDE6G;SPTAN1;ADD2;MYO7A;GBP1;USH1G;ADD1;EPB49;DCTN2
structural constituent of cytoskeletonNEFH;SPTAN1;TLN2A;INA;TPM1;EPB41L4B;TUBA8;ARPC2;EPB41L3
structural molecule activityJUP;KRT26;NEFLB;CLDN11;CLDN19;BGLAP;LAMC3;MAP1B;FGG

ANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK1.

OBSCN; OBSCN; HSPB1

Hughes, MR; Anderson, N; et al. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. EXPERIMENTAL HEMATOLOGY 39:305-320(2011).
Giacomello, E; Sorrentino, V; et al. Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres. HISTOCHEMISTRY AND CELL BIOLOGY 131:371-382(2009).
  • Q&As
  • Reviews

Q&As (13)

Ask a question
What research is currently being conducted on ANK1-related disorders? 11/30/2022

Ongoing research on ANK1-related disorders focuses on understanding the underlying molecular mechanisms, exploring the full spectrum of associated symptoms and complications, developing better diagnostic methods, and investigating potential targeted therapies. Researchers are also studying the role of ANK1 in other diseases, such as cardiovascular disorders and neurological conditions.

Can ANK1 mutations cause other types of diseases besides those mentioned earlier? 11/20/2022

While ANK1 mutations are most commonly associated with conditions affecting red blood cells, recent studies have also identified their potential involvement in other disorders. For example, ANK1 mutations have been implicated in hereditary spherocytosis-associated gallstones and an increased risk of gallbladder cancer. Moreover, there is evidence suggesting ANK1 gene variations may contribute to susceptibility to certain cardiovascular diseases, such as atrial fibrillation and myocardial infarction. However, further research is required to ascertain the precise role of ANK1 mutations in these conditions.

What are the potential functions of ANK1 protein besides its role in red blood cells? 04/08/2022

While ANK1 is well-known for its importance in maintaining the shape and stability of red blood cells, recent research has unveiled its involvement in various other cellular processes. ANK1 has been found in the brain, where it interacts with components of the cytoskeleton and contributes to the organization and function of nerve cells. Additionally, ANK1 is present in skeletal muscles and has been implicated in the development and maintenance of muscle structure. These findings suggest that ANK1 may have diverse functions beyond the red blood cell membrane.

What are the long-term complications or health risks associated with ANK1-related disorders? 12/15/2021

The long-term complications and health risks associated with ANK1-related disorders primarily depend on the specific disorder and its severity. In hereditary spherocytosis and related conditions, individuals may experience chronic anemia, jaundice, gallstones, and an increased risk of serious infections.

Are there any specific drugs or compounds that can modulate ANK1 activity? 04/21/2021

At present, there are no specific drugs or compounds available that specifically target ANK1 activity. However, researchers are actively investigating potential small molecules or compounds that could modulate ANK1 function. These studies aim to identify molecules that could interact with ANK1 or associated pathways to potentially develop targeted therapies for diseases associated with ANK1 dysfunction.

Are there any treatment options available for ANK1-related disorders? 07/27/2020

The treatment options for ANK1-related disorders depend on the specific disorder and its severity. In milder cases, regular monitoring of blood cell counts and managing symptoms, such as anemia, may be sufficient. For individuals with more severe symptoms, treatment may involve blood transfusions to address chronic anemia or surgical removal of the gallbladder in cases of gallstones. In some cases, splenectomy (surgical removal of the spleen) may be necessary to manage complications such as splenomegaly or to decrease the destruction of red blood cells. Genetic counseling is also recommended for affected individuals and their families to discuss the inheritance pattern and assess the risk of passing on the mutation.

Can ANK1 protein be targeted for therapeutic purposes? 05/07/2019

Currently, there are no specific therapies targeting ANK1 protein. However, research efforts are underway to explore potential therapeutic strategies. In the case of hereditary spherocytosis and related disorders, treatment mainly focuses on managing the symptoms, such as anemia, through blood transfusions or splenectomy. Gene therapy approaches that aim to correct or replace the defective ANK1 gene are also being investigated as potential future treatments.

Are there any other functions or roles of ANK1 protein? 03/04/2019

Apart from its role in maintaining cell shape and integrity, ANK1 protein has also been implicated in other cellular processes. It has been shown to interact with various ion channels and transporters, participating in the regulation of cell volume, membrane potential, and signal transduction in specific cell types. Additionally, ANK1 has been identified as a tumor suppressor gene and has been associated with certain types of cancer. However, further research is needed to fully understand these additional roles and their mechanisms.

Is there any ongoing research related to the ANK1 protein? 01/10/2019

Yes, there is ongoing research related to ANK1 protein. Scientists are studying the structure and function of ANK1 in more detail to gain a deeper understanding of its role in cellular processes and diseases. They are also investigating potential therapeutic approaches that target ANK1 or associated pathways. Additionally, further research is being conducted to explore the involvement of ANK1 in cancer development and progression.

What happens if ANK1 protein is dysfunctional? 06/17/2018

Mutations in the ANK1 gene can cause various forms of hereditary spherocytosis, a condition characterized by abnormal red blood cell morphology leading to hemolytic anemia. In these cases, the ANK1 protein is either partially or completely deficient, leading to weakened interaction between the cytoskeleton and the plasma membrane, resulting in the loss of cell membrane integrity and increased susceptibility to cell rupture.

Are there any diseases other than hereditary spherocytosis associated with ANK1 protein? 10/09/2017

Apart from hereditary spherocytosis, ANK1 mutations have been associated with other related conditions, such as hereditary elliptocytosis and pyropoikilocytosis. These conditions involve abnormal red blood cell morphology, similar to spherocytosis. ANK1 mutations have also been linked to a rare neurological disorder known as spinocerebellar ataxia type 37 (SCA37), characterized by progressive cerebellar degeneration and ataxia. Additionally, there is emerging research suggesting a potential role of ANK1 in certain types of cancer, although more studies are needed to establish a clear association.

How common are ANK1-related disorders? 12/24/2016

ANK1-related disorders, such as hereditary spherocytosis, are considered relatively rare. The exact prevalence is difficult to determine, as the disorder can vary in severity and may be underdiagnosed due to mild or atypical symptoms. It has been estimated that hereditary spherocytosis occurs in approximately 1 in 2,000 to 5,000 individuals, with some populations having higher prevalence rates. Other ANK1-related conditions, such as elliptocytosis, are even rarer. However, advances in genetic testing and increased awareness may lead to more accurate prevalence estimates in the future.

Can ANK1 mutations be inherited? 05/11/2016

Yes, ANK1 mutations can be inherited in an autosomal dominant or autosomal recessive manner. In autosomal dominant inheritance, only one copy of the mutated ANK1 gene is necessary for the disorder to be inherited. This means that if a person has an affected parent, they have a 50% chance of inheriting the mutated gene and developing the disorder. In autosomal recessive inheritance, both copies of the ANK1 gene must be mutated for the disorder to be inherited. This means that both parents must be carriers of a mutated gene, and each child has a 25% chance of inheriting the disorder.

Customer Reviews (4)

Write a review
Reviews
02/22/2022

    With their support, I can confidently explore the intricacies of ANK1 and make significant contributions to the understanding of its functions in various biological processes.

    05/26/2020

      The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach further reinforce its suitability for my research.

      08/27/2019

        This existing knowledge base provides a solid foundation for designing experiments and interpreting results, ultimately enhancing the efficiency and reliability of trials involving ANK1 protein.

        03/03/2018

          Extensive research has been conducted on ANK1, making it relatively accessible and well-understood in terms of its structure and functions.

          Ask a Question for All ANK1 Products

          Required fields are marked with *

          My Review for All ANK1 Products

          Required fields are marked with *

          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends