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AQPEP

  • Official Full Name

    laeverin

  • Synonyms

    AQPEP; laeverin; aminopeptidase Q; APQ; FLJ90650; MGC125378; MGC125379; RGD1562779; CHL2 antigen; LVRN; AP-Q;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AQPEP-654HCL Recombinant Human AQPEP cell lysate N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AQPEP Related Articles

AQPEP involved in several pathways and played different roles in them. We selected most pathways AQPEP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AQPEP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AQPEP has several biochemical functions, for example, metallopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AQPEP itself. We selected most functions AQPEP had, and list some proteins which have the same functions with AQPEP. You can find most of the proteins on our site.

Function Related Protein
metallopeptidase activityADAM10A;ADAMTS8;ADAMTS16;ANPEPA;STAMBPA;ADAMTS4;DPP3;MMP25;ACE
zinc ion bindingMLL5;TRIM4;NR5A5;SIRT6;KDM5B;RFPL1;TRIM35-30;TRAF5;TRIM17

AQPEP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQPEP here. Most of them are supplied by our site. Hope this information will be useful for your research of AQPEP.

Fujiwara, H; Higuchi, T; et al. Regulation of human extravillous trophoblast function by membrane-bound peptidases. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1751:26-32(2005).
Fujiwara, H; Higuchi, T; et al. Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 313:962-968(2004).
  • Q&As
  • Reviews

Q&As (26)

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Is the AQPEP protein found on the cell surface or within cellular compartments? 02/07/2023

The AQPEP protein can be found both on the cell surface and within cellular compartments. It is membrane-bound, with a cytoplasmic region and an extracellular domain. However, its precise localization and trafficking may vary depending on the cell type and physiological conditions.

Is the AQPEP protein being targeted for therapeutic intervention? 12/16/2022

While there are no specific therapeutics targeting the AQPEP protein currently approved for clinical use, the ongoing research on AQPEP's involvement in various diseases may lead to the development of novel therapeutic approaches. Modulating the activity or expression of AQPEP could be a potential strategy for treating diseases related to peptide metabolism, hypertension, and other conditions associated with AQPEP dysregulation.

Is the AQPEP protein being targeted for therapeutic intervention? 12/16/2022

While there are no specific therapeutics targeting the AQPEP protein currently approved for clinical use, the ongoing research on AQPEP's involvement in various diseases may lead to the development of novel therapeutic approaches. Modulating the activity or expression of AQPEP could be a potential strategy for treating diseases related to peptide metabolism, hypertension, and other conditions associated with AQPEP dysregulation.

Where is the AQPEP protein primarily found in the body? 11/25/2022

The AQPEP protein is widely distributed in various tissues and organs throughout the body. It can be found in the kidney, liver, intestine, brain, and other tissues.

Are there any specific cell types where AQPEP is predominantly expressed? 08/27/2022

The expression of AQPEP is found in various tissues and cell types, but some studies indicate that it is predominantly expressed in the renal proximal tubules. AQPEP is also found in other organs such as the lungs, liver, and brain, albeit at lower levels. Its expression can vary depending on the tissue and physiological conditions.

Are there any specific cell types where AQPEP is predominantly expressed? 08/27/2022

The expression of AQPEP is found in various tissues and cell types, but some studies indicate that it is predominantly expressed in the renal proximal tubules. AQPEP is also found in other organs such as the lungs, liver, and brain, albeit at lower levels. Its expression can vary depending on the tissue and physiological conditions.

Have there been any studies on the AQPEP protein's role in cancer? 08/26/2022

Yes, there have been studies investigating the role of the AQPEP protein in cancer. Some research suggests that AQPEP may have a tumor suppressor function and its decreased expression or activity is associated with the progression and metastasis of certain cancers. Further studies are needed to fully elucidate its involvement in different cancer types.

What are some potential future implications of studying the AQPEP protein? 06/28/2022

Studying the AQPEP protein may have several potential future implications. It could lead to a better understanding of peptide metabolism and its impact on various physiological processes. Additionally, it may uncover new therapeutic targets for diseases associated with dysregulated peptide metabolism, potentially paving the way for the development of targeted treatments.

Are there any known inhibitors or activators of the AQPEP protein? 12/27/2021

Yes, there are known inhibitors and activators of the AQPEP protein. Some compounds, such as bestatin and amastatin, are known inhibitors of AQPEP's enzymatic activity. Additionally, certain activators or stimulators, such as angiotensin II, have been found to upregulate AQPEP expression or activity in certain contexts.

Does the AQPEP protein have any other known functions besides peptide hydrolysis? 06/19/2021

Yes, besides its role in peptide hydrolysis, the AQPEP protein has been associated with additional functions. It has been found to interact with other proteins involved in cellular signaling and trafficking pathways, suggesting potential roles beyond its enzymatic activity. Further research is needed to fully understand these additional functions.

Does the AQPEP protein have any other known functions besides peptide hydrolysis? 06/19/2021

Yes, besides its role in peptide hydrolysis, the AQPEP protein has been associated with additional functions. It has been found to interact with other proteins involved in cellular signaling and trafficking pathways, suggesting potential roles beyond its enzymatic activity. Further research is needed to fully understand these additional functions.

What molecular pathways or factors regulate AQPEP expression? 04/12/2021

The regulation of AQPEP expression is not yet fully understood, but several factors and molecular pathways have been implicated. For instance, it has been reported that various hormones, such as angiotensin II, insulin, and glucocorticoids, can regulate AQPEP expression levels. Additionally, inflammatory mediators and growth factors may also affect AQPEP expression. Further studies are needed to comprehensively elucidate the molecular mechanisms underlying AQPEP regulation.

What molecular pathways or factors regulate AQPEP expression? 04/12/2021

The regulation of AQPEP expression is not yet fully understood, but several factors and molecular pathways have been implicated. For instance, it has been reported that various hormones, such as angiotensin II, insulin, and glucocorticoids, can regulate AQPEP expression levels. Additionally, inflammatory mediators and growth factors may also affect AQPEP expression. Further studies are needed to comprehensively elucidate the molecular mechanisms underlying AQPEP regulation.

Are there any known genetic variations or mutations associated with the AQPEP protein? 03/11/2021

Yes, there are known genetic variations and mutations in the AQPEP gene that can affect the AQPEP protein's function. These variations may contribute to certain diseases or conditions, such as hypertension, diabetic nephropathy, and diabetic retinopathy. Further research is needed to fully understand the implications of these genetic variations.

Are there any genetic disorders associated with AQPEP mutations? 02/22/2021

To date, there are no known genetic disorders specifically associated with AQPEP mutations. However, genetic variations or mutations in the AQPEP gene have been implicated in certain diseases, as mentioned earlier, such as hypertension, diabetic nephropathy, and diabetic retinopathy. Additional studies are required to establish a direct link between AQPEP mutations and specific genetic disorders.

Are there any genetic disorders associated with AQPEP mutations? 02/22/2021

To date, there are no known genetic disorders specifically associated with AQPEP mutations. However, genetic variations or mutations in the AQPEP gene have been implicated in certain diseases, as mentioned earlier, such as hypertension, diabetic nephropathy, and diabetic retinopathy. Additional studies are required to establish a direct link between AQPEP mutations and specific genetic disorders.

Is there any evidence suggesting a link between the AQPEP protein and neurodegenerative diseases? 05/18/2020

Yes, there is emerging evidence suggesting a potential link between the AQPEP protein and neurodegenerative diseases. Studies have found altered expression and activity of AQPEP in the brains of patients with neurodegenerative disorders like Alzheimer's disease. However, further research is needed to fully understand the implications and mechanisms of this association.

Is there any evidence suggesting a link between the AQPEP protein and neurodegenerative diseases? 05/18/2020

Yes, there is emerging evidence suggesting a potential link between the AQPEP protein and neurodegenerative diseases. Studies have found altered expression and activity of AQPEP in the brains of patients with neurodegenerative disorders like Alzheimer's disease. However, further research is needed to fully understand the implications and mechanisms of this association.

Is the AQPEP protein being researched for its potential role in human diseases? 03/06/2020

Yes, the AQPEP protein is the subject of ongoing research to investigate its potential involvement in various human diseases. Studies are exploring its role in conditions such as hypertension, cardiovascular diseases, kidney disorders, and cancer. Understanding the role of AQPEP in these diseases may lead to the development of new therapeutic strategies.

What are the potential implications of AQPEP dysregulation in cardiovascular diseases? 02/09/2020

Dysregulation of AQPEP has been implicated in various cardiovascular diseases. For example, decreased expression or activity of AQPEP has been observed in patients with hypertension, a condition characterized by high blood pressure. AQPEP plays a role in the regulation of vasoconstrictor peptides like angiotensin II, and its dysregulation can lead to imbalances in blood pressure regulation.

What are the potential implications of AQPEP dysregulation in cardiovascular diseases? 02/09/2020

Dysregulation of AQPEP has been implicated in various cardiovascular diseases. For example, decreased expression or activity of AQPEP has been observed in patients with hypertension, a condition characterized by high blood pressure. AQPEP plays a role in the regulation of vasoconstrictor peptides like angiotensin II, and its dysregulation can lead to imbalances in blood pressure regulation.

Does the AQPEP protein have any known substrates? 10/22/2019

Yes, the AQPEP protein has known substrates that it cleaves. It primarily cleaves N-terminal amino acids from peptides, and specific substrates include angiotensins, bradykinins, and enkephalins. These substrates are involved in various physiological processes such as blood pressure regulation and pain perception.

Are there any known pharmacological inhibitors or activators of the AQPEP protein? 08/02/2018

Yes, there are pharmacological inhibitors and activators that have been identified for the AQPEP protein. Bestatin and amastatin are commonly used inhibitors of AQPEP's enzymatic activity. On the other hand, angiotensin II has been reported to activate AQPEP expression or activity in certain contexts.

Are there any known pharmacological inhibitors or activators of the AQPEP protein? 08/02/2018

Yes, there are pharmacological inhibitors and activators that have been identified for the AQPEP protein. Bestatin and amastatin are commonly used inhibitors of AQPEP's enzymatic activity. On the other hand, angiotensin II has been reported to activate AQPEP expression or activity in certain contexts.

Is AQPEP expression altered in kidney diseases? 04/20/2017

Yes, AQPEP expression has been found to be altered in kidney diseases. For example, in diabetic nephropathy, which is a common complication of diabetes affecting the kidneys, decreased AQPEP expression has been observed. This dysregulation may contribute to important pathophysiological processes such as increased blood pressure, renal inflammation, and fibrosis. Additionally, studies have also investigated the potential role of AQPEP in other kidney diseases such as glomerulonephritis and acute kidney injury, suggesting its involvement in renal function and pathology.

Is AQPEP expression altered in kidney diseases? 04/20/2017

Yes, AQPEP expression has been found to be altered in kidney diseases. For example, in diabetic nephropathy, which is a common complication of diabetes affecting the kidneys, decreased AQPEP expression has been observed. This dysregulation may contribute to important pathophysiological processes such as increased blood pressure, renal inflammation, and fibrosis. Additionally, studies have also investigated the potential role of AQPEP in other kidney diseases such as glomerulonephritis and acute kidney injury, suggesting its involvement in renal function and pathology.

Customer Reviews (8)

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Reviews
07/20/2022

    With the AQPEP protein and the manufacturer's support, I can confidently pursue my research goals and achieve meaningful outcomes.

    06/02/2022

      Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.

      02/08/2022

        This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.

        08/26/2021

          The versatility of the AQPEP protein extends beyond these applications, enabling its use in a wide range of experimental techniques.

          03/31/2017

            the AQPEP protein comes highly recommended for its exceptional performance in Western blot analysis and its utility in protein electron microscopy structure analysis.

            02/10/2017

              Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating AQPEP protein function and molecular interactions.

              02/09/2017

                Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.

                01/05/2016

                  Its versatility and reliability make it an excellent choice for researchers seeking to delve deeper into the mechanisms and functions of the AQPEP protein.

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