ARHGEF4 Protein, Rho guanine nucleotide exchange factor (GEF) 4

ARHGEF4

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ARHGEF4

Official Full Name Rho guanine nucleotide exchange factor (GEF) 4
Background Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
Synonyms ARHGEF4; Rho guanine nucleotide exchange factor (GEF) 4; rho guanine nucleotide exchange factor 4; APC stimulated guanine nucleotide exchange factor; ASEF; KIAA1112; STM6; ARHGEF 4; GEF 4; GEF; GEF4; STM 6; APC-stimulated guanine nucleotide exchange factor 1; ASEF1
    • Species :
    • Human
    • Source :
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF4-787H Recombinant Human ARHGEF4 protein, GST-tagged Wheat Germ GST
    Human ARHGEF4-8730HCL Recombinant Human ARHGEF4 293 Cell Lysate HEK293 N/A

    ARHGEF4 involved in several pathways and played different roles in them. We selected most pathways ARHGEF4 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of actin cytoskeleton FGF2; ACTB1; PFN4; ITGA3; PIP5K1B; ITGB2; RHOAC; TMSB4Y; FN1; TMSB

    ARHGEF4 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF4 itself. We selected most functions ARHGEF4 had, and list some proteins which have the same functions with ARHGEF4. You can find most of the proteins on our site.

    Function Related Protein
    Rac guanyl-nucleotide exchange factor activity ARHGEF2; VAV3; SPATA13; DOCK2; FARP1; ARHGEF4; PREX2; FARP2; ALS2; VAV1
    guanyl-nucleotide exchange factor activity CHRM4; FFAR1; SERGEF; ARHGEF37; RIC8B; TAGAP; DIS3; DOCK1; RASGEF1BB; DOCK11
    protein binding DOCK9; ASPH; PRDX4; NRP1B; PLCB4; MED6; ZNRF1; HSPBAP1; EHHADH; TNS4
    protein domain specific binding TJP2; CAPG; RHOA; SNCA; SERPINB1A; TNNI3; MPP5; TWIST1; PPP3R1; NR0B1

    ARHGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF4.

    HLA-B; RAC1; NEDD8

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