arhgef4
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  • Official Full Name
  • Rho guanine nucleotide exchange factor (GEF) 4
  • Background
  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
  • Synonyms
  • ARHGEF4; Rho guanine nucleotide exchange factor (GEF) 4; rho guanine nucleotide exchange factor 4; APC stimulated guanine nucleotide exchange factor; ASEF; KIAA1112; STM6; ARHGEF 4; GEF 4; GEF; GEF4; STM 6; APC-stimulated guanine nucleotide exchange factor 1; ASEF1
Cat.#:ARHGEF4-787HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARHGEF4 protein, GST-tagged
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Cat.#:ARHGEF4-8730HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARHGEF4 293 Cell Lysate
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Involved Pathway

ARHGEF4 involved in several pathways and played different roles in them. We selected most pathways ARHGEF4 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of actin cytoskeleton
EZRB; PIK3R1; MSNA; FGF19; PPP1CC; FGF1A; WASLB; CDC42L2; RAF1A; MSNB

Protein Function

ARHGEF4 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF4 itself. We selected most functions ARHGEF4 had, and list some proteins which have the same functions with ARHGEF4. You can find most of the proteins on our site.
Function
Related Protein
Function Rac guanyl-nucleotide exchange factor activity
Related Protein VAV1; FARP1; SPATA13; FARP2; PREX2; ARHGEF2; VAV3; ARHGEF4; ALS2; DOCK2
Function guanyl-nucleotide exchange factor activity
Related Protein RASGRF2B; RPGR; PREX1; ANKRD27; DOCK11; PTGIR; FGD5; DIS3; DOCK7; RAPGEF3
Function protein binding
Related Protein GABBR2; LGALS9C; BCKDHA; FAM21C; AVPR1A; SPEF2; CPT1B; NPC2; CAMP; FHL3
Function protein domain specific binding
Related Protein PPP3R1; FOXH1; SHROOM2; CEP68; HIST1H4B; GABRR1; COX4I2; HIST1H4N; ARFIP2B; DBNL

Interacting Protein

ARHGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF4.
HLA-B; RAC1; NEDD8