• Official Full Name
  • chromosome 7 open reading frame 16
  • Background
  • The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • chromosome 7 open reading frame 16; GSBS; G-substrate; OTTHUMP00000158793; OTTHUMP00000202600

C7orf16 Related Articles

Iizuka, M; Murata, T; et al. Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 300:G1010-G1021(2011).
Murthy, KS; Zhou, HP; et al. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via G(i3), Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. BIOCHEMICAL JOURNAL 374:145-155(2003).