CA15-3
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Official Full Name
Cancer Antigen 15-3
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Overview
Breast cancer is the most frequent form of cancer (excluding non-melanoma skin cancers) amongst women and is the leading cause of cancer death in women between the ages of 40 and 55. One of the key markers for this disease is the Cancer Antigen 15-3, other markers also include CA549. CA15-3 is a mucin-type glycoprotein with a high molecular weight. It is localised to the apical side of alveoli and ducts on mammary glands and is present as a circulating antigen. CA15-3 is found in greater than 80% of all cases of metastatic Breast Cancer. CA15-3 can be elevated in benign conditions, especially those hepatic in origin, however these elevated CA15-3 levels are rarely above 100 U/ml. Elevated CA15-3 is only found in 5% of healthy controls. There is no correlation between serum CA 15-3 levels, disease stage and prognosis. However very high CA15-3 levels (5 – 10 times the normal) tend to indicate advanced disease and possibly the presence of metastatic disease. Studies have suggested that there is a good general correlation between changing CA 15-3 levels and response to therapy in metastatic cancer, but that it cannot be relied on in the absence of confirming clinical data. Cancer Antigen 15-3 levels are also increased in Colon, Lung and Hepatic Tumours -
Synonyms
CA15-3 Cancer Antigen (Breast Cancer); CA15-3; Breast CA15-3;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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CDA003 | Human Cancer Antigen CA15-3 (Breast Cancer) Calibrator Grade | Human | N/A |
- CA15-3 Related Articles
CA15-3 involved in several pathways and played different roles in them. We selected most pathways CA15-3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CA15-3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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CA15-3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CA15-3 itself. We selected most functions CA15-3 had, and list some proteins which have the same functions with CA15-3. You can find most of the proteins on our site.
Function | Related Protein |
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CA15-3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA15-3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA15-3.
- Q&As
- Reviews
Q&As (7)
Ask a questionCA15-3 is released into the bloodstream from tumor cells, making it a potential marker for monitoring certain cancers, especially breast cancer.
CA15-3 is a specific epitope or form of the CA15 protein, making it distinct in terms of detection.
Some benign conditions, like liver disease or benign breast disorders, can elevate CA15-3 levels.
Elevated CA15-3 levels may indicate tumor presence or growth, while decreasing levels might suggest effective treatment.
Hemolysis, certain medications, or other non-cancerous conditions might interfere with assay results.
Immunoassays, such as ELISA, are commonly used for CA15-3 detection.
Sensitivity and specificity vary by test, but CA15-3 is typically used in conjunction with other markers and tests.
Customer Reviews (3)
Write a reviewInvaluable for our critical protein analysis experiments.
Expert guidance, improves the quality of our protein samples.
Cost-efficient assays, fit well within our research budget.
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