• Official Full Name
  • CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
  • Background
  • CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC);(see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003;(PubMed 12766176); Bermudez et al., 2003 (PubMed 12930902)).
  • Synonyms
  • CHTF18; CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); C16orf41, chromosome 16 open reading frame 41; chromosome transmission fidelity protein 18 homolog; C321D2.4; CHL12; Ctf18; MGC38008; 6030457M03Rik; C16orf41; C321D2.2; C321D2.3; chromosome transmission fidelity factor 18 homolog (S. cerevisiae); RUVBL; hCTF18; OTTHUMP00000045506; OTTHUMP00000208409; homolog of yeast CHL12; C321D2.3 (novel protein); C321D2.4 (novel protein); some homology with holliday junction DNA helicase RUVB like
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHTF18 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHTF18 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHTF18
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CHTF18
Source (Host):Species:Human
Product nameRecombinant Human CHTF18 cell lysate

Involved Pathway

CHTF18 involved in several pathways and played different roles in them. We selected most pathways CHTF18 participated on our site, such as Gastric cancer network 2, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHTF18 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gastric cancer network 2

Protein Function

CHTF18 has several biochemical functions, for example, ATP binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHTF18 itself. We selected most functions CHTF18 had, and list some proteins which have the same functions with CHTF18. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein ABL2; ZAP70; SMARCA4; MYO19; CAMK2D; ANKK1; ACTA1; MARK4; GPHN; PFKFB3
Function DNA binding
Related Protein ZBTB5; PEG10; ZNF621; HER13; ZNF177; ZNF367; HOXC12B; PTF1A; CREBZF; SCMH1

Interacting Protein

CHTF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHTF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHTF18.
CRK; STAT3; STAT3; ssdna_dc; XRCC3; MYC; FAM83H; Phospho1

CHTF18 Related Articles

Khaku, Z; Dia, F; et al. A Role for CHTF18 in Meiotic Recombination and DNA Crossover Formation in Mammals.. REPRODUCTIVE SCIENCES 21:226A-226A(2014).
Price, JC; Pollock, LM; et al. Sequencing of Candidate Chromosome Instability Genes in Endometrial Cancers Cancers Reveals Somatic Mutations in ESCO1, CHTF18, and MRE11A. PLOS ONE 8:-(2013).