• Official Full Name
  • CENPL centromere protein L [ Homo sapiens ]
  • Background
  • This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.
  • Synonyms
  • CENP-L; C1orf155; dJ383J4.3; RP3-383J4.1; centromere protein L; interphase centromere complex protein 33; chromosome 1 open reading frame 155; Interphase centromere complex protein 3