CREB3L2
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Official Full Name
cAMP responsive element binding protein 3-like 2
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Overview
CREB3L2 is a member of the old astrocyte specifically induced substance (OASIS) DNA binding and basic leucine zipper dimerization (bZIP) family of transcription factors, which includes CREB3 (MIM 606443) and CREB4 (MIM 607138). -
Synonyms
CREB3L2; cAMP responsive element binding protein 3-like 2; cyclic AMP-responsive element-binding protein 3-like protein 2; BBF2H7; TCAG_1951439; Basic transcription factor 2; BBF2 human homolog on chromosome 7; BZIB transcription factor; cAMP responsive element binding protein 3 like 2; cAMP-responsive element-binding protein 3-like protein 2; FUS/BBF2H7 protein; MGC131709; MGC71006; OTTHUMP00000208572; OTTHUMP00000208573; B-ZIB transcription factor; cAMP-responsive element-binding;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Human
- Mouse
- Rat
- Xenopus laevis (African clawed frog)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CREB3L2 involved in several pathways and played different roles in them. We selected most pathways CREB3L2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB3L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | PDE3B;INS1;PPP1CC;ATP1B4;MEF2A;RGS2;CALML5;CREB3L3;CALM1 |
| cAMP signaling pathway | NFKBIA;CALM4;RAP1A;RAP1B;GLI3;HCAR3;MAP2K1;HTR6;GPR119 |
| PIK-Akt signaling pathway | MTOR;INS2;PPP2R2A;YWHAH;SGK3;PTEN;NFKB1;FGF11;COL4A1 |
| AMPK signaling pathway | HMGCR;ACACB;PRKAG1;EIF4EBP1;SIRT1;LIPE;Scd2;RPS6KB2;CREB1 |
| Adrenergic signaling in cardiomyocytes | PPP1CC;ATP1B2B;PPP1CBL;GNA15.4;ADRa1A;ATP1B2;TNNC1;PRKACBA;CACNG6A |
| TNF signaling pathway | TNFRSF1A;ITCH;PIK3CG;CASP7;ATF4;PTGS2;MMP3;MAP3K7;MAP3K14 |
| Cholinergic synapse | CHRM4;CHRNA4;GNB4;CREB3L1;GNG13;ITPR1;CHRNA6;PLCB2;GNGT1 |
| Dopaminergic synapse | PPP3CB;CREB3L1;PPP2R2C;PPP1CC;CALML5;MAPK13;PPP2CB;GNGT1;MAPK12 |
| Insulin secretion | ATP1A1;GCG;CREB3L1;CREB3L3;KCNJ11;PRKACB;ATF4;INS2;ATP1B2 |
| Estrogen signaling pathway | MAPK1;Adcy4;KCNJ6;PLCB1;KCNJ9;ATF4;HSPA1L;CREB3L1;HSPA1A |
| Melanogenesis | WNT5B;PRKCA;PLCB1;TCF7L1A;KITB;MAP2K2B;WNT6;NRAS;FZD5 |
| Thyroid hormone synthesis | SLC26A4;GPX6;IYD;GPX8;ATP1B4;GPX3;CREB3L3;GPX7;PRKCA |
| Aldosterone synthesis and secretion | NPR1;CREB3;CALM2;HSD3B1;GNAQ;CYP11B2;ATF4;PRKACA;GNA11 |
| Insulin resistance | SLC27A1B;IRS2;INS2;RPS6KA2;PRKAB1A;TRIB3;PIK3CD;TNFRSF1A;SLC2A4 |
| Huntingtons disease | NDUFA7;COX4I1;UQCR10;POLR2H;DNAH6;COX8A;COX5A;COX7B2;UQCRQ |
| Cocaine addiction | NFKB1;PRKACB;BDNF;SLC6A3;GRIN2B;CREB3L4;GRIA2;CREB3;GRIN2C |
| Alcoholism | HIST1H2AH;GRIN2B;SOS1;HIST1H2BE;GRIN1;GM6026;HDAC9;HIST1H2AK;GNAI3 |
| Hepatitis B | MAP2K1;YWHAB;IKBKB;CCNE2;Ifna11;TLR2;IFNAR1;VDAC3;STAT1 |
| Viral carcinogenesis | MRPS18B;HDAC10;HIST2H4;Casp3;RBL1;HIST1H2BI;SYK;HPN;SRC |
| Prostate cancer | CCND1;CREB5;FGFR2;RB1;SMARCA4;INSRR;MAPK1;NOXA1;PDPK1 |
CREB3L2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB3L2 itself. We selected most functions CREB3L2 had, and list some proteins which have the same functions with CREB3L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | STAT3;DLX5;ZFP536;FOS;ESR1;RAX;FOXL2;GLI3;CREB1 |
| cAMP response element binding | HMGA2;CREB3L3L;CREB3L1;CREB1;CREB3L3A;ATF6;CREB3L2;E4F1;CREB3L3 |
| transcription regulatory region DNA binding | KLF1;ATF6B;TAF2;RFX6;CDK5RAP2;AHR;TP53;KLF2A;GFI1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NR5A2;PAX5;TLX1;POU4F3;NR4A2;E2F4;SOX2;FOXA1;FOXI1 |
CREB3L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB3L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB3L2.
Dynll1; RGS16; GAS7; GCFC2; PXN; q5nfy4_fratt; RND1; PTP4A1; CEP19; GULP1; ZNF212
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