dok6
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  • Official Full Name
  • docking protein 6
  • Background
  • DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM;164761) signaling cascade (Crowder et al., 2004 (PubMed 15286081)).
  • Synonyms
  • DOK6; docking protein 6; docking protein 5 like , DOK5L; HsT3226; MGC20785; downstream of tyrosine kinase 6; DOK5L
Cat.#:DOK6-2815HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DOK6 Protein, GST-tagged
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Cat.#:DOK6-363HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DOK6 Protein, His-tagged
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Cat.#:DOK6-4765MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DOK6 Protein
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Cat.#:DOK6-1313RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DOK6 Protein, His-tagged
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Cat.#:DOK6-5558ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DOK6
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Cat.#:DOK6-6844HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DOK6 293 Cell Lysate
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Involved Pathway

DOK6 involved in several pathways and played different roles in them. We selected most pathways DOK6 participated on our site, such as Signaling events regulated by Ret tyrosine kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events regulated by Ret tyrosine kinase
DOK6; DOK5; DOK4; GFRA1; GDNF; PDLIM7

Protein Function

DOK6 has several biochemical functions, for example, insulin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK6 itself. We selected most functions DOK6 had, and list some proteins which have the same functions with DOK6. You can find most of the proteins on our site.
Function
Related Protein
Function insulin receptor binding
Related Protein DOK5; DOK4; PTPN1; IRS1; PDPK1; FRS2B; LMBRD1; SNX4; FRS3; GRB10
Function protein binding
Related Protein CLCF1; ATP5O; EIF2AK2; TRIM63; TRAF6; MTERF; CCR5; ATP1B1; C22orf28; NMI

Interacting Protein

DOK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK6.
C1orf94; RBPMS; EGFR; ERBB2; ESR2

DOK6 Related Articles

Lapelosa, M; Patapoff, TW; et al. Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies. JOURNAL OF PHYSICAL CHEMISTRY B 118:13132-13141(2014).
Al Olaby, RR; Cocquerel, L; et al. Identification of a Novel Drug Lead That Inhibits HCV Infection and Cell-to-Cell Transmission by Targeting the HCV E2 Glycoprotein. PLOS ONE 9:-(2014).