• Official Full Name
  • E2F transcription factor 8
  • Background
  • This gene encodes a member of a family of transcription factors which regulate the expression of genes required for;progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the;nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been;identified.
  • Synonyms
  • E2F8; E2F transcription factor 8; transcription factor E2F8; FLJ23311; E2F 8; E2F family member 82; E2F-8; E2F8_HUMAN; OTTHUMP00000231893; OTTHUMP00000231894; E2F family member 8
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F8 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E2F8 Protein
Source (Host):Species:Human
Product nameRecombinant Human E2F8 293 Cell Lysate

Protein Function

E2F8 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F8 itself. We selected most functions E2F8 had, and list some proteins which have the same functions with E2F8. You can find most of the proteins on our site.
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein JUNBB; ARNT2; SOX10; NRF1; TCF12; ZNF562; ZSCAN21; RBPJA; TCF4; POU3F2
Function core promoter binding
Related Protein SFPQ; E2F7; NKX3-1; KDM3A; REST; RBMX; E2F3; RB1; NOTCH1; CCAR1
Function protein binding
Related Protein UBOX5; MPG; EEF2; TTPA; IGBP1; ZNF624; PSMB9; PAX3; MEPE; LARP1
Function protein homodimerization activity
Related Protein TENM2; HMGCR; KLRB1B; MAP3K9; BARD1; TYR; DMRT2B; ABCB10; CAV2; ATP2A1
Function transcription corepressor activity
Related Protein NAB2; SKOR1B; AEBP2; SSX5; ALX1; E2F8; LHX1A; SKOR2; NSD1; NR0B2
Function transcription factor activity, sequence-specific DNA binding
Related Protein TBX2B; CBFA2T2; ZIC1; ZFP42; FOXG1C; MYC; CTBP1; HIRA; ETS1; DMRT3
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SREBF2; ASCL2; MZF1; AEBP2; SP3; CC2D1B; PROX1B; BCL11AB; OVOL1; PROX2

Interacting Protein

E2F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F8.

E2F8 Related Articles

Umemura, S; Shirane, M; et al. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. BRITISH JOURNAL OF CANCER 100:764-771(2009).
Panchuk, RR; Boiko, NM; et al. Changes in signaling pathways of cell proliferation and apoptosis during NK/Ly lymphoma aging. CELL BIOLOGY INTERNATIONAL 32:1057-1063(2008).