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Official Full Name E2F transcription factor 8
Background This gene encodes a member of a family of transcription factors which regulate the expression of genes required for;progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the;nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been;identified.
Synonyms E2F8; E2F transcription factor 8; transcription factor E2F8; FLJ23311; E2F 8; E2F family member 82; E2F-8; E2F8_HUMAN; OTTHUMP00000231893; OTTHUMP00000231894; E2F family member 8
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human E2F8-4284H Recombinant Human E2F8 Protein, GST-tagged Wheat Germ GST
    Human E2F8-6740HCL Recombinant Human E2F8 293 Cell Lysate HEK293 N/A
    Mouse E2F8-4937M Recombinant Mouse E2F8 Protein Mammalian Cell His

    E2F8 involved in several pathways and played different roles in them. We selected most pathways E2F8 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    E2F8 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F8 itself. We selected most functions E2F8 had, and list some proteins which have the same functions with E2F8. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NPAS4; TBP; MITFB; CEBPG; NKX2; NEUROG3; HOXD13; HOXC11; MZF1; ZNF460
    core promoter binding RB1; HDAC4; NEUROG3; HNRNPU; KLF4; FOXP3; SPI1; NKX3; MED1; CALCOCO1
    protein binding BCL2L1; MAGEA2; ZNF148; HIF1AN; KLRC4-KLRK1; NUDT14; HDGF2; THBS2; LRRFIP1; RIC8A
    protein homodimerization activity XDH; TNNC1; ACOT7; RCHY1; ATF3; LSM1; GPD1C; GYS2; BNIP3; TSG101
    transcription corepressor activity ZNF593; GMNN; NEUROD2; MAP3K10; SIRT6; DR1; EID1; TRIM22; KLF12; LIMD1
    transcription factor activity, sequence-specific DNA binding SOX9; HLFA; XBP1; NFIXB; SIX2; GTF2H2; ZFP628; MEF2A; RFX8; ZNF500
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NACC2; MZF1; CC2D1A; NFIL3-5; GATA3; ZFPM1; SREBF2; NR2C1; TBX15; PROX1A

    E2F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F8.

    TFCP2; FHL3; E2F7; ZDHHC17

    Umemura, S; Shirane, M; et al. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. BRITISH JOURNAL OF CANCER 100:764-771(2009).
    Panchuk, RR; Boiko, NM; et al. Changes in signaling pathways of cell proliferation and apoptosis during NK/Ly lymphoma aging. CELL BIOLOGY INTERNATIONAL 32:1057-1063(2008).

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