Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels,;suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus;provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope;glycoprotein gene which appears to have been selectively preserved. The genes protein product plays a major role in;placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope;protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a;heterodimer.
ERVFRD-1; endogenous retrovirus group FRD, member 1; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; envFRD; ERVFRDE1; HERV FRD; HERV W/FRD; syncytin 2; envelope polyprotein; endogenous retrovirus group FRD member 1; HERV-FRD provirus ancestral Env po
Vargas, A; Zhou, SF; et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB JOURNAL 28:3703-3719(2014).