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Elastase

Official Full Name

Elastase
Overview

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Elastase is a serine protease which exhibits endopeptidase activity on many proteins, its principal substrate, however, is elastin and it is unique among proteases in its ability to hydrolyse native elastin. It is present in the pancreas, leukocytes and serum. Elastase consists of a single polypeptide chain with a molecular weight of 29.5kDa. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Elastase 1 is not a pancreatic enzyme: clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.
Synonyms

Elastase; ELA 1; ELA2A; ELA 2B; ELA 3; ELA 3A; ELA 3B; Fecal pancreatic elastase 1; HLE; Medullasin; Pancreatic elastase IIA; PE 1; Protease E;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	Elastase-01H	Active Native Human Sputum Leucocyte Elastase	Leucocytes			Inquiry

Elastase Related Articles

Elastase involved in several pathways and played different roles in them. We selected most pathways Elastase participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Elastase were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Elastase has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Elastase itself. We selected most functions Elastase had, and list some proteins which have the same functions with Elastase. You can find most of the proteins on our site.

Function	Related Protein

Elastase has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elastase here. Most of them are supplied by our site. Hope this information will be useful for your research of Elastase.

Munoz-Caro, T; Huertas, SJM; et al. Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent. VETERINARY RESEARCH 46:-(2015).

Schreiber, A; Luft, FC; et al. Phagocyte NADPH Oxidase Restrains the Inflammasome in ANCA-Induced GN. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 26:411-424(2015).