• Official Full Name
  • forkhead box E3
  • Background
  • This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia.
  • Synonyms
  • FOXE3; forkhead box E3; FKHL12; forkhead box protein E3; FREAC8; Forkhead related protein FKHL12; Drosphilia Forkhead Homolog Like 12; FKHL 12; Forkhead BoxE3; Forkhead Related Activator 8; FOXE3 forkhead box E3; FREAC 8; FREAC-8; forkhead-related protein FKHL12; forkhead, drosophila, homolog-like 12; forkhead-related transcription factor 8
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FOXE3
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FOXE3

Protein Function

FOXE3 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXE3 itself. We selected most functions FOXE3 had, and list some proteins which have the same functions with FOXE3. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein TBX22; ZNF182; OVOL2; POLDIP2; TLX2; ZNF426; EBF4; TNP2; GTF2IRD2; ENG2A
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein TP73; FOXI3A; OVOL1; SIM1A; FLI1A; ELK4; TAL1; TRP53; TFAP2B; SOX5
Function sequence-specific DNA binding
Related Protein NFYB; NKX3.3; OTX1A; HOXA11B; FOXF1; RORCB; HOXD4; NKX6.3; MSXE; NR2F6
Function transcription factor activity, sequence-specific DNA binding
Related Protein TSC22D2; HNF4A; ZSCAN23; STAT5B; STAT4; ZNF498; TFCP2L1; FOXQ1B; ZNF643; ZNF334

FOXE3 Related Articles

Terrell, AM; Anand, D; et al. Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes. EXPERIMENTAL EYE RESEARCH 131:42-55(2015).
Anchan, RM; Lachke, SA; et al. Pax6- and Six3-Mediated Induction of Lens Cell Fate in Mouse and Human ES Cells. PLOS ONE 9:-(2014).