• Official Full Name
  • FRAS1 related extracellular matrix protein 2
  • Background
  • This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
  • Synonyms
  • FREM2; FRAS1 related extracellular matrix protein 2; FRAS1-related extracellular matrix protein 2; ECM3 homolog;
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FREM2 Protein

Protein Function

FREM2 has several biochemical functions, for example, calcium ion binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FREM2 itself. We selected most functions FREM2 had, and list some proteins which have the same functions with FREM2. You can find most of the proteins on our site.
Related Protein
Function calcium ion binding
Related Protein MYL10; GAS6; CABP7; EHD1B; MMP1; NUCB2A; UMOD; MMP12; MICU1; FBN2B
Function metal ion binding
Related Protein BA1; PDE1B; ZFYVE26; PDLIM3B; EBF3A; FBXL19; SNAI1; ROCK1; LIG4; GNAI2
Function protein binding
Related Protein SRGN; MYCBP; CCDC92; SPTBN1; CA8; PPP3R2; IL10RB; PHIP; ATP6V1C2; FADD

FREM2 Related Articles

Lloreda-Garcia, JM; Gonzalez-Rodriguez, JD; et al. Fraser syndrome caused by a new mutation in the FREM2 gene. ANALES DE PEDIATRIA 82:207-208(2015).
Biswas, NK; Chandra, V; et al. Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM. SCIENTIFIC REPORTS 5:-(2015).