• Official Full Name
  • glial cells missing homolog 2 (Drosophila)
  • Background
  • Gcm2, a mouse ortholog of the Drosophila Glial Cells Missing gene, is expressed in the parathyroid-specific domains in the 3rd pouches from E9.5. The null mutation of Gcm2 causes aparathyroidism in the fetal and adult mouse and has been proposed to be a master regulator for parathyroid development. During Drosophila embryogenesis Gcm2 plays a crucial role in promoting glial cell differentiation.
  • Synonyms
  • GCM2; glial cells missing homolog 2 (Drosophila); chorion-specific transcription factor GCMb;
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GCM2 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GCM2
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GCM2

Protein Function

GCM2 has several biochemical functions, for example, DNA binding, metal ion binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCM2 itself. We selected most functions GCM2 had, and list some proteins which have the same functions with GCM2. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein SMG6; PBX3B; ILF2; TCF4; RBFOX3; LCOR; PHOX2BB; KIF4; HESX1; MBD3A
Function metal ion binding
Related Protein ZC3H3; PDLIM3A; TRIM35-20; MOXD1L; MORC1; MARCH6; ADARB1; GNAT1; ZNF227; ZNF576.2
Function sequence-specific DNA binding
Related Protein SOX21B; SOX21A; NKX6.3; ZBTB14; PBX3B; FOXF2; MSXC; PRRX2; HOXC4; ATF7
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATOH1; RARG; RFX2; PRDM1; SPZ1; FOXQ2; UHRF1; TBR1B; ZNF549; SRF

GCM2 Related Articles

D'Agruma, L; Coco, M; et al. Increased Prevalence of the GCM2 Polymorphism, Y282D, in Primary Hyperparathyroidism: Analysis of Three Italian Cohorts. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E2794-E2798(2014).
Mitsui, T; Narumi, S; et al. Comprehensive Next-Generation Sequencing Analyses of Hypoparathyroidism: Identification of Novel GCM2 Mutations. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E2421-E2428(2014).