• Official Full Name
  • glucocorticoid receptor DNA binding factor 1
  • Background
  • The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
  • Synonyms
  • p190A; AI841135; Arhgap35; mKIAA1722; p190RhoGAP; 6430596G11Rik

GRLF1 Related Articles

Asai, A; Karnan, S; et al. High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas. GENE 558:220-226(2015).
Cecchinato, A; Ribeca, C; et al. Candidate gene association analysis for milk yield, composition, urea nitrogen and somatic cell scores in Brown Swiss cows. ANIMAL 8:1062-1070(2014).