HHAT Protein, hedgehog acyltransferase


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Official Full Name hedgehog acyltransferase
Background Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
Synonyms HHAT; hedgehog acyltransferase; protein-cysteine N-palmitoyltransferase HHAT; FLJ10724; GUP2; MART 2; MART2; rasp; sit; ski; Skn; 2810432O22Rik; AI462858; FLJ34867; AC115917.1; HHAT_HUMAN; MART-2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; OTTHUMP00000034608; OTTHUMP00000034611
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cell His
    Zebrafish HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cell His

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis, Signal Transduction, Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog ligand biogenesis DISP2; SCUBE2; DERL2; NOTUM; NOTUM1A; GPC5A; HHAT; OS9
    Signal Transduction RGS21; CXCR7B; WDR35; ASH2L; ARHGAP9; WIPF3; ADH8B; CDON; ACKR4; SH2B3
    Signaling by Hedgehog IQCE; IFT172; SPOPL; RPGRIP1L; EVC2; WDR35; WDR19; CDON; KIF7; IFT52

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity, 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity, 2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity NAT14; HHAT; DGAT2L6; MBOAT4; MBOAT1; LPCAT3; CML5; MBOAT7; Acnat1; CML2
    2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity MBOAT1; ACNAT2; Acnat1; NAT14; MBOAT4; DGAT2L6; CML2; MBOAT7; CML5; HHAT
    2-methylhexanoyl-CoA C-acetyltransferase activity ACNAT2; MBOAT4; CML2; LPCAT3; MBOAT1; HHAT; MBOAT7; CML5; Acnat1; NAT14
    3-hydroxybutyryl-CoA thiolase activity MBOAT4; MBOAT7; CML5; LPCAT3; Acnat1; HHAT; MBOAT1; ACNAT2; NAT14; CML2
    3-ketopimelyl-CoA thiolase activity LPCAT3; CML5; ACNAT2; DGAT2L6; MBOAT7; MBOAT4; CML2; NAT14; MBOAT1; HHAT
    C-acyltransferase activity MBOAT4; LPCAT3; DGAT2L6; NAT14; MBOAT7; Acnat1; HHAT; CML5; ACNAT2; MBOAT1
    C-palmitoyltransferase activity Acnat1; CML2; CML5; NAT14; LPCAT3; HHAT; ACNAT2; MBOAT4; DGAT2L6; MBOAT7
    GTP binding MX2; MX1; TUBG1; RAB5C; RAB34; GTPBP10; EEF1A1L2; IRGQ; RAB12; RAB4A
    L-2-aminoadipate N-acetyltransferase activity ACNAT2; DGAT2L6; MBOAT1; CML2; LPCAT3; CML5; NAT14; MBOAT4; HHAT; Acnat1
    N-acetyltransferase activity SAT1A.1; NAT9; CML2; SMARCE1; SAT2A; NAT15; Acnat1; NAA10; AANAT2; HHAT
    N-acyltransferase activity BAAT; CML5; Acnat1; MBOAT1; ACNAT2; DGAT2L6; CML2; HHAT; HRASLS5; NAT14
    N-palmitoyltransferase activity MBOAT4; CML5; DGAT2L6; MBOAT7; CML2; Acnat1; LPCAT3; ACNAT2; NAT14; HHAT
    N-succinyltransferase activity CML2; DGAT2L6; NAT14; ACNAT2; MBOAT7; Acnat1; LPCAT3; CML5; HHAT; MBOAT4
    O-acetyltransferase activity MBOAT4; NAT14; HHAT; CML2; ACNAT2; CML5; MBOAT1; DGAT2L6; MBOAT7; Acnat1
    O-acyltransferase activity LPCAT3; DGAT1B; NAT14; PLA2G15; DGAT1A; CML5; DGAT2L6; CML2; Acnat1; HHAT
    O-octanoyltransferase activity Acnat1; MBOAT4; NAT14; MBOAT1; MBOAT7; CML5; DGAT2L6; HHAT; CML2; LPCAT3
    O-palmitoyltransferase activity Acnat1; CML5; DGAT2L6; NAT14; CML2; MBOAT4; ACNAT2; MBOAT1; LPCAT3; MBOAT7
    O-sinapoyltransferase activity HHAT; CML5; MBOAT4; MBOAT1; ACNAT2; DGAT2L6; LPCAT3; NAT14; Acnat1; MBOAT7
    O-succinyltransferase activity DGAT2L6; ACNAT2; NAT14; MBOAT4; CML5; CML2; LPCAT3; MBOAT1; MBOAT7; HHAT
    Ras palmitoyltransferase activity Acnat1; CML5; LPCAT3; ZDHHC9; ACNAT2; CML2; DGAT2L6; NAT14; MBOAT4; MBOAT1
    S-acetyltransferase activity CML2; ACNAT2; LPCAT3; CML5; NAT14; MBOAT7; HHAT; MBOAT1; Acnat1; DGAT2L6
    S-acyltransferase activity MBOAT1; HHAT; MBOAT7; MBOAT4; Acnat1; CML2; DGAT2L6; CML5; ACNAT2; NAT14
    S-malonyltransferase activity ACNAT2; MBOAT1; MBOAT4; DGAT2L6; LPCAT3; MBOAT7; CML2; HHAT; NAT14; CML5
    S-succinyltransferase activity LPCAT3; CML5; HHAT; ACNAT2; MBOAT7; MBOAT4; CML2; Acnat1; DGAT2L6; MBOAT1
    UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity NAT14; LPCAT3; CML2; DGAT2L6; Acnat1; CML5; MBOAT4; ACNAT2; MBOAT1; MBOAT7
    acetyl-CoA:L-lysine N6-acetyltransferase CML5; ACNAT2; DGAT2L6; CML2; LPCAT3; HHAT; MBOAT1; NAT14; MBOAT7; Acnat1
    acetyltransferase activity ACNAT2; MBOAT1; MBOAT4; KAT8; CML5; MBOAT7; KAT5; HHAT; Nat3; KAT6B
    acyl-CoA N-acyltransferase activity DGAT2L6; Acnat1; MBOAT4; CML5; HHAT; ACNAT2; CML2; LPCAT3; NAT14; MBOAT1
    acylglycerol O-acyltransferase activity MBOAT1; LPCAT3; MBOAT4; NAT14; MBOAT7; DGAT2L6; ACNAT2; Acnat1; CML2; HHAT
    azetidine-2-carboxylic acid acetyltransferase activity CML2; MBOAT7; MBOAT1; CML5; NAT14; HHAT; Acnat1; MBOAT4; DGAT2L6; LPCAT3
    benzoyl acetate-CoA thiolase activity MBOAT7; LPCAT3; HHAT; CML5; ACNAT2; CML2; DGAT2L6; NAT14; MBOAT1; Acnat1
    butyryl-CoA 2-C-propionyltransferase activity LPCAT3; Acnat1; DGAT2L6; HHAT; CML5; MBOAT4; CML2; NAT14; ACNAT2; MBOAT7
    carnitine O-acyltransferase activity MBOAT4; Acnat1; ACNAT2; MBOAT1; MBOAT7; NAT14; CML2; LPCAT3; HHAT; CML5
    dihydrolipoamide S-acyltransferase activity CML2; LPCAT3; Acnat1; MBOAT1; HHAT; ACNAT2; NAT14; MBOAT7; MBOAT4; CML5
    dihydrolipoamide branched chain acyltransferase activity MBOAT7; LPCAT3; ACNAT2; CML5; MBOAT1; CML2; Acnat1; HHAT; MBOAT4; NAT14
    ergosterol O-acyltransferase activity ACNAT2; LPCAT3; Acnat1; MBOAT4; NAT14; MBOAT7; MBOAT1; HHAT; DGAT2L6; CML5
    glucosaminyl-phosphotidylinositol O-acyltransferase activity MBOAT4; HHAT; ACNAT2; LPCAT3; NAT14; MBOAT7; Acnat1; DGAT2L6; CML2; CML5
    keto acid formate lyase activity MBOAT1; MBOAT4; HHAT; MBOAT7; NAT14; CML2; LPCAT3; ACNAT2; Acnat1; CML5
    lanosterol O-acyltransferase activity HHAT; DGAT2L6; LPCAT3; CML2; MBOAT7; MBOAT1; MBOAT4; ACNAT2; Acnat1; NAT14
    malonyltransferase activity LPCAT3; MBOAT1; CML5; HHAT; CML2; ACNAT2; DGAT2L6; NAT14; MBOAT4; MBOAT7
    myristoyltransferase activity NAT14; MBOAT4; CML5; ACNAT2; LPCAT3; MBOAT1; HHAT; MBOAT7; Acnat1; CML2
    naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity MBOAT7; Acnat1; DGAT2L6; CML2; LPCAT3; NAT14; ACNAT2; MBOAT1; MBOAT4; HHAT
    nucleotide binding BMPR1AB; RHOAE; PPIP5K2; RMI1; CDK14; CLK4B; DHRS3; RBMY1B; ITPK1A; ATP2B3A
    octanoyltransferase activity MBOAT1; LIPT2; ACNAT2; NAT14; CML2; CML5; MBOAT4; Acnat1; MBOAT7; LPCAT3
    palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity MBOAT1; CML2; MBOAT4; HHAT; MBOAT7; CML5; ACNAT2; Acnat1; LPCAT3; DGAT2L6
    palmitoyltransferase activity DGAT2L6; ZDHHC1; MBOAT4; NAT14; Acnat1; LPCAT3; ZDHHC16; ZDHHC5A; ZDHHC17; ACNAT2
    peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor MBOAT1; CML5; NAA50; MBOAT4; NAT14; LPCAT3; ACNAT2; Acnat1; CML2; HHAT
    peptidyl-lysine N6-myristoyltransferase activity HHAT; DGAT2L6; NAT14; MBOAT4; ACNAT2; MBOAT7; LPCAT3; CML2; Acnat1; MBOAT1
    peptidyl-lysine N6-palmitoyltransferase activity Acnat1; MBOAT4; LPCAT3; NAT14; ACNAT2; CML2; HHAT; CML5; MBOAT7; DGAT2L6
    protein-cysteine S-acyltransferase activity CML5; NAT14; CML2; DGAT2L6; LPCAT3; ACNAT2; HHAT; Acnat1; MBOAT1; MBOAT7
    protein-cysteine S-myristoyltransferase activity CML2; LPCAT3; CML5; DGAT2L6; MBOAT7; HHAT; ACNAT2; MBOAT4; MBOAT1; Acnat1
    serine O-acyltransferase activity MBOAT4; NAT14; ACNAT2; CML5; LPCAT3; Acnat1; DGAT2L6; CML2; MBOAT1; MBOAT7
    sinapoyltransferase activity CML5; CML2; Acnat1; DGAT2L6; MBOAT7; ACNAT2; MBOAT1; LPCAT3; HHAT; NAT14
    sterol O-acyltransferase activity Acnat1; MBOAT4; NAT14; HHAT; MBOAT1; CML5; DGAT2L6; CML2; MBOAT7; LPCAT3
    succinyltransferase activity MBOAT7; MBOAT1; Acnat1; CML2; MBOAT4; CML5; LPCAT3; DGAT2L6; HHAT; NAT14
    transferase activity UGT1B2; TAOK3; GGT7; FKRP; GBGT1L3; KITA; CSNK1DA; RPS6KA3A; UGT5B4; C1GALT1A
    transferase activity, transferring acyl groups ZDHHC13; CML2; MEIS2; ZDHHC23B; AANAT1; ZDHHC18A; GGT7; ZDHHC16B; AGPAT9L; ZDHHC18B

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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