This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
HOXD11 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD11 itself. We selected most functions HOXD11 had, and list some proteins which have the same functions with HOXD11. You can find most of the proteins on our site.
Function sequence-specific DNA binding
Related Protein DBX1B; FOXC1; HOXB6; MAFF; DMRTA2; SALL1A; HOXA11B; VDRA; MNX2A; NOTCH1
HOXD11 Related Articles
Gross, S; Krause, Y; et al. Hoxa11 and Hoxd11 Regulate Chondrocyte Differentiation Upstream of Runx2 and Shox2 in Mice. PLOS ONE 7:-(2012).
Lee, HJ; Jang, SJ; et al. Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. EXPERIMENTAL LUNG RESEARCH 37:344-353(2011).