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IPO4

Official Full Name

importin 4
Overview

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Synonyms

IPO4; importin 4; Imp4; importin-4; imp4b; ranBP4; importin-4b; ran-binding protein 4;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

C
Myc
DDK
GST
His
His (Fc)
Avi
Myc|DDK
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IPO4-144H	Recombinant Human IPO4, GST-tagged	E.coli	GST	C-term-354aa	$319 / 25ug
Human	IPO4-293H	Recombinant Human IPO4 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Human	IPO4-2444H	Recombinant Human IPO4 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	IPO4-8263M	Recombinant Mouse IPO4 Protein	Mammalian Cell	His		Inquiry
Mouse	Ipo4-3565M	Recombinant Mouse Ipo4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Ipo4-1689M	Recombinant Mouse Ipo4 Protein, His-tagged	E.coli	N-His	Met1-Arg189	Inquiry
Mouse	IPO4-4580M	Recombinant Mouse IPO4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IPO4-4580M-B	Recombinant Mouse IPO4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
IPO4 Related Articles

IPO4 involved in several pathways and played different roles in them. We selected most pathways IPO4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

IPO4 has several biochemical functions, for example, Ran GTPase binding, nuclear localization sequence binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO4 itself. We selected most functions IPO4 had, and list some proteins which have the same functions with IPO4. You can find most of the proteins on our site.

Function	Related Protein
Ran GTPase binding	RANBP10;TNPO1;IPO4;RANBP1;KPNB1;DPY19L2;XPOT;IPO8;IPO13
nuclear localization sequence binding	KPNB3;RANBP6;TNPO2;IPO5;IPO4;IPO13;TNPO1;KPNA5;NFKBIA
protein binding	FOXRED2;MYH7;ILF3;SULT4A1;ENTPD1;AAAS;YY1AP1;GAGE1;SEPT3
protein transporter activity	RAMP3;SEC61G;TMCO6;CALCRL;KPNA6;IPO11;VPS35;L7RN6;EIF4ENIF1

IPO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO4.

MYC; HIST1H3D; q76353_9hiv1; 7242199; SGK1; PTP4A3; CIAO1; BAP1; BRF2; NEK6; ASF1B; GSTK1; PHLDA3; p27958-pro_0000037576; VAV2; ezrA; MED19

Loginsky, VE; Vygovska, YI; et al. Immunophenotypic characterization of blood lymphoid cells in chronic lymphocytic leukemia complicated by immune cytopenias. EXPERIMENTAL ONCOLOGY 18:37-42(1996).