• Official Full Name
  • importin 4
  • Background
  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
  • Synonyms
  • IPO4; importin 4; Imp4; importin-4; imp4b; ranBP4; importin-4b; ran-binding protein 4;
Source (Host):HEK293Species:Human
Product nameRecombinant Human IPO4 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IPO4, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IPO4 Protein

Protein Function

IPO4 has several biochemical functions, for example, Ran GTPase binding, nuclear localization sequence binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO4 itself. We selected most functions IPO4 had, and list some proteins which have the same functions with IPO4. You can find most of the proteins on our site.
Related Protein
Function Ran GTPase binding
Related Protein XPO4; NUP153; IPO11; RANBP3; RANGAP1; IPO9; NXT1; XPOT; KPNB1; IPO5
Function nuclear localization sequence binding
Related Protein KPNA1; KPNB1; KPNA5; KPNA3; KPNA6; KPNA2; TNPO1; IPO4; TNPO3; RANBP6
Function protein binding
Related Protein PHF16; CXXC5; TXNRD2; COL1A1; STYX; HECTD3; FGFR2; AP4B1; NPL; CPSF2
Function protein transporter activity

Interacting Protein

IPO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO4.
MYC; HIST1H3D; q76353_9hiv1; 7242199; SGK1; PTP4A3; CIAO1; BAP1; BRF2; NEK6; ASF1B; GSTK1; PHLDA3; p27958-pro_0000037576; VAV2; ezrA; MED19

IPO4 Related Articles

Loginsky, VE; Vygovska, YI; et al. Immunophenotypic characterization of blood lymphoid cells in chronic lymphocytic leukemia complicated by immune cytopenias. EXPERIMENTAL ONCOLOGY 18:37-42(1996).