• Official Full Name
  • KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
  • Background
  • Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
  • Synonyms
  • ER lumen protein retaining receptor 1; ERD2.1; ERD21_HUMAN; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Kdelr1; Putative MAPK-activating protein PM23
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KDELR1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KDELR1 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KDELR1 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human KDELR1 293 Cell Lysate

Involved Pathway

KDELR1 involved in several pathways and played different roles in them. We selected most pathways KDELR1 participated on our site, such as Vibrio cholerae infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vibrio cholerae infection

Protein Function

KDELR1 has several biochemical functions, for example, KDEL sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR1 itself. We selected most functions KDELR1 had, and list some proteins which have the same functions with KDELR1. You can find most of the proteins on our site.
Related Protein
Function KDEL sequence binding
Related Protein KDELR1; KDELR2

Interacting Protein

KDELR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDELR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KDELR1.
ctxA; Copb1; ARF1; SERINC3; SEC23A; Arfgap1; Tmed10; BZW1; BRF2; NEK6; WBP5