killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
KIR2DS5; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer cell immunoglobulin-like receptor 2DS5; CD158G; nkat9; CD158 antigen like family member G; Flags: Precursor; Killer cell immunoglobulin like receptor 2DS5; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 5; MHC class I NK cell receptor; Natural killer associated transcript 9; Natural killer cell inhibitory receptor; NKAT 9; NKAT-9; CD158 antigen-like family member G; natural killer-associated transcript 9
KIR2DS5 involved in several pathways and played different roles in them. We selected most pathways KIR2DS5 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
KIR2DS5 has several biochemical functions, for example, HLA-C specific inhibitory MHC class I receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DS5 itself. We selected most functions KIR2DS5 had, and list some proteins which have the same functions with KIR2DS5. You can find most of the proteins on our site.
Function HLA-C specific inhibitory MHC class I receptor activity
Related Protein KIR2DS5
KIR2DS5 Related Articles
De Re, V; Caggiari, L; et al. Genetic Diversity of the KIR/HLA System and Outcome of Patients with Metastatic Colorectal Cancer Treated with Chemotherapy. PLOS ONE 9:-(2014).
Czaja, K; Borer, AS; et al. A comprehensive analysis of the binding of anti-MR antibodies to activating KIRs. GENES AND IMMUNITY 15:33-37(2014).
Naumova, E; Ivanova, M; et al. 16th IHIW: Immunogenetics of Aging. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 40:77-81(2013).
Naumova, E; Ivanova, M; et al. 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. TISSUE ANTIGENS 77:187-192(2011).