lars2
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  • Official Full Name
  • leucyl-tRNA synthetase 2, mitochondrial
  • Background
  • This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
  • Synonyms
  • LARS2; leucyl-tRNA synthetase 2, mitochondrial; probable leucyl-tRNA synthetase, mitochondrial; KIAA0028; leucine tRNA ligase 2; mitocondrial; LEURS; MGC26121; mitochondrial; LARS 2; Leucine translase; Leucine tRNA ligase 2 mitocondrial; Leucine tRNA ligase; Leucine--tRNA ligase; Leucyl tRNA synthetase 2; Leucyl tRNA synthetase 2 mitochondrial; Probable leucyl-tRNA synthetase; SYLM_HUMAN; OTTHUMP00000164232; OTTHUMP00000210279; OTTHUMP00000210280; leucine tRNA ligase 2, mitocondrial
Cat.#:LARS2-510HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LARS2, GST-tagged
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Cat.#:LARS2-8961MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LARS2 Protein
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Cat.#:LARS2-6037ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LARS2
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Cat.#:LARS2-972HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LARS2 cell lysate
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Involved Pathway

LARS2 involved in several pathways and played different roles in them. We selected most pathways LARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LARS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
MARS2; VARS; TARS2; FARSB; SARS2; VARS2; GATB; DARS2; YARS; PARS2

Protein Function

LARS2 has several biochemical functions, for example, ATP binding, aminoacyl-tRNA editing activity, leucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LARS2 itself. We selected most functions LARS2 had, and list some proteins which have the same functions with LARS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ULK3; HARS; FGFR1B; NAT1; PDGFRB; NLRP9B; CDK9; AK8; SRX1; MAP4K2
Function aminoacyl-tRNA editing activity
Related Protein AARS; VARS; LARS2; VARS2; LARS; IARS; IARS2; PRORSD1; DTD2; DTD1
Function leucine-tRNA ligase activity
Related Protein LARS2; LARS

LARS2 Related Articles

Pierce, SB; Gersak, K; et al. Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome. AMERICAN JOURNAL OF HUMAN GENETICS 92:614-620(2013).
Li, RH; Guan, MX; et al. Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes. MOLECULAR AND CELLULAR BIOLOGY 30:2147-2154(2010).