Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel;beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic;ligands and transport them to specific cells (Suzuki et al., 2004 (PubMed 15363845)).
Cheng, L; Xing, H; et al. Lipocalin-2 Promotes M1 Macrophages Polarization in a Mouse Cardiac Ischaemia-Reperfusion Injury Model. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:31-38(2015).
Yan, JR; Li, GH; et al. Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).