LYZ
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Official Full Name
lysozyme
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Overview
The acronym ANCA (Antineutrophil Cytoplasmic Autoantibodies) is defined by an accumulation of autoantibodies with specificity against different granulocytic, monocytic and probably endothelial cytoplasmic antigens. PR3 and MPO are well defined as reliable serological markers for a definite group of primary systemic vasculitides (PSV), which were also named ANCA associated vasculitides (AAV). The occurrence of AAV is clearly higher than supposed. The incidence is 1.5 per 1000 and in the group of older persons nearly 5 per 1000. The clinical appearance of the AAV is characterized through manifestations in lung, kidney and respiratory tract. In the last years, newer investigations discovered and characterised a couple of new pANCA antigens: Elastase, Cathepsin G, Lysozyme and Lactoferrin. Up to now, ANCA screening has been done with immunofluorescence techniques, but often there have been difficulties in the evaluation and in clinical findings. Therefore, the results have to be scrutinised with counter examinations on other cells or in other test systems like ELISA. Moreover it was not possible to differentiate the single cANCA and pANCA antigens.<br/>1. Proteinase 3<br/>The major antigen for the cANCA reactivity is the neutral serine protease 3 (synonyms: p29, AGP7, Wegener autoantigen), which belongs to the Trypsin/Chymotrypsin family. In 1988 several groups showed that the antigen is a protein with a molecular weight of 29 kDa. PR3 was already described in 1973 by Ohlsson and Olsson under the name neutrophile collagenase. In the meantime it seams certain, that autoantibodies against PR3 are highly specific as serological marker for the diagnosis of Wegener's granulomatosis (specificity: initial phase 50%, generalization phase >90%).Moreover there is a correlation between the concentration of the autoantibodies and the disease activity.<br/>2. Myeloperoxidase<br/>Myeloperoxidase is the major antigen in nearly 60% of the pANCA findings. The occurrence of autoantibodies against MPO is classified as relevant marker for the rapid progressive nephritis. Moreover these antibodies occur in 70-90% in all patients with serious kidney injury. Over and about they have also been detected at the Churg-Strauss-Syndrom (CSS), Microscopic Polyangiitis (MPA) and other vasculitis diseases. The concentration of the autoantibodies correlates well with the disease activity of MPA. MPA is also characterised by clinical manifestations of lung, kidney and respiratory tract, but these manifestations are, in contrast to WG, not granulomatous. However, these antibodies have, in contrast to the high specificity of PR3 anti-bodies for WG, a minor specificity of 60% in the diagnosis of MPA. The absence of autoantibodies against MPO and PR3, by simultaneous detection of ANA can be used as a tool for differential diagnosis between AAV and SLE induced vasculitis.<br/>3. BPI<br/>Bactericidal permeability-increasing protein, BPI is a membrane-located protein that is classed as an ANCA-Antigen of polymorph-nuclear granulocytes and monocytes that bind endotoxin. Its autoantibodies are now classified as cANCA. Due to BPIs high affinity to lipopolysaccharides its antimicrobial effect against Gram-negative bacteria is significant. BPI is cleaved and thus inactivated by using Elastase or other serine protease. Autoantibodies against BPI are above all detected in chronically infectious intestinal diseases such as Morbus Crohn or colitis ulcerosa. In contrast to anti-MPO and anti-PR3 autoantibodies, those against BPI seem not to have any association with vasculitis.<br/>4. Elastase<br/>Elastase is a serine protease with a sequence homology of 54% to that of proteinase 3. It occurs mainly in polymorph-nuclear neutrophil granulocytes (PMN), in macrophages and endothelial cells. The dismantling of proteoglycans by neutrophiles is mainly due to Elastase's proteolytic activity. Furthermore, Elastase participates decisively in tissue destruction connected with emphysemas and rheumatoid arthritis. Autoantibodies against this antigen are generally associated with inflammatory rheumatic disorders, e.g. rheumatoid arthritis and vasculitis.<br/>5. Cathepsin G<br/>The cathepsins belong to a group of intracellular proteases mainly found in lysosomes, especially of the spleen, the liver and the kidney. Cathepsin G is a serine protease and a further pANCA antigen. It participates to a great part in the destruction of osteoid tissue as of its hydrolytic properties. The autoantibodies against Cathepsin G occur mainly in collagenosis and other related inflammatory rheumatic diseases, e.g. SLE, Sj?gren′s syndrome and Felty's syndrome.<br/>6. Lysozyme<br/>Lysozyme is a glycosidase, which decomposes the glycosidic bond between C-1 of MNAc and C-4 of GlcNAc. Lysozyme is localised in the azurophilic as well as in the specific granules of neutrophils and in extracellular liquid compartments like tears and salivary, where it spreads out his antimicrobial activities against invading bacteria. LZ belongs also to the pANCA and autoantibodies against Lysozyme occur in higher frequency in rheumatoid vasculitis and inflammatory bowel disease like colitis ulcerosa.<br/>7. Lactoferrin<br/>Lactoferrin (LF) is an iron-binding protein, which occurs in high concentrations in secretions at mucosa surfaces, in tears and in milk. LF also resides in the specific granules of polymorphnuclear neutrophil leukocytes (PMN) and becomes exocytosed upon PMN activation. During active inflammatory disease, raised serum levels of LF can be measured. The physiological antimicrobial effect of Lactoferrin depends on its iron-binding capacity, because most of the bacteria require iron for their own physiological pathways. LF inhibits myelopoiesis, prevents complement activation and prevents the formation of hydroxyl radicals. It is quite possible that LF has several important roles, like secretory IgA, as a non-specific antiphlogistic defence factor at mucosal surfaces. LF belongs to the pANCA, depending on the redistribution from the granules toward the nuclei, upon ethanol fixation. Autoantibodies against Lactoferrin occur in higher frequency in patients with rheumatoid vasculitis (RV), colitis ulcerosa (CU) and primary sclerosing cholangitis (PSC). -
Synonyms
LYZ; lysozyme; lysozyme (renal amyloidosis); lysozyme C; renal amyloidosis; 1,4-beta-N-acetylmuramidase C; LZM;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Bovine
- Chicken
- Gallus gallus (Chicken)
- Human
- Lophura Leucomelanos
- Rhesus Macaque
- Zebrafish
- Chicken Egg
- Chicken egg white
- Chicken Egg White
- E.coli
- HEK293
- Human Blood
- Human Neutrophil
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Rice Grain
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|SUMO
- SUMO
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | LYZ-64H | Active Recombinant Human Lysozyme | Rice Grain | N/A | ||
Human | LYZ-04H | Active Recombinant Human Lysozyme | N/A | |||
Human | LYZ-249H | Active Native Human Lysozyme | Human Neutrophil | N/A | ||
Human | LYZ-29007TH | Active Native Human LYZ | Human Blood | N/A | 130 amino acids | |
Human | LYZ-5785H | Recombinant Human LYZ protein, His-tagged | E.coli | His | Cys24~Gln144 (Accession# P61626) | |
Human | LYZ-275H | Recombinant Human LYZ protein, His-tagged | HEK293 | His | Lys19-Val148 | |
Human | LYZ-1033H | Recombinant Human LYZ, MYC/DDK-tagged, 13C & 15N Labeled | HEK293 | Myc/DDK | ||
Human | LYZ-4580HCL | Recombinant Human LYZ 293 Cell Lysate | HEK293 | N/A | ||
Human | LYZ-5316H | Native Human Lysozyme(salivary) | Human Blood | N/A | ||
Human | LYZ-4533H | Recombinant Human LYZ Protein, GST-tagged | Wheat Germ | GST | ||
Human | LYZ-27700TH | Native Human LYZ | Human Neutrophil | N/A | ||
Human | LYZ-3196H | Recombinant Human LYZ protein, His-SUMO-tagged | E.coli | His-SUMO | 19-148aa | |
Human | LYZ-2582HFL | Recombinant Full Length Human LYZ, Flag-tagged | Mamanlian cells | Flag | ||
Human | LYZ-4478H | Recombinant Human LYZ Protein (Lys19-Val148), C-His tagged | Mammalian cells | C-His | Lys19-Val148 | |
Human | LYZ-3414H | Recombinant Human LYZ Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | LYZ-6038HF | Recombinant Full Length Human LYZ Protein, GST-tagged | In Vitro Cell Free System | GST | 148 amino acids | |
Human | LYZ-3414H-B | Recombinant Human LYZ Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | LYZ-4479H | Recombinant Human LYZ Protein (Lys19-Val148), N-His tagged | E.coli | N-His | Lys19-Val148 | |
Bovine | LYZ-05B | Recombinant Bovine LYZ protein, His-tagged | E.coli | His | Gly18~Leu147 | |
Gallus gallus (Chicken) | LYZ-683G | Natural Gallus gallus (Chicken) domesticus allergen 4 (LYZ) protein | Chicken egg white | |||
Lophura Leucomelanos | LYZ-1940L | Recombinant Lophura Leucomelanos LYZ Protein (1-129 aa), His-SUMO-tagged | E.coli | His/SUMO | 1-129 aa | |
Rhesus Macaque | LYZ-2612R | Recombinant Rhesus monkey LYZ Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | LYZ-2432R-B | Recombinant Rhesus Macaque LYZ Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | LYZ-2432R | Recombinant Rhesus Macaque LYZ Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | LYZ-9402Z | Recombinant Zebrafish LYZ | Mammalian Cell | His | ||
Chicken | LYZ-65E | Lysozyme From Chicken Eggs (Food Grade) | Chicken Egg | N/A | ||
Chicken | LYZ-6833C | Recombinant Chicken LYZ | Mammalian Cell | His | ||
Chicken | LYZ-5784C | Recombinant Chicken LYZ protein, His-tagged | E.coli | His | Lys19~Leu147 | |
Chicken | LYZ-1501C | Recombinant Chicken LYZ protein | E.coli | N/A | 19-147aa | |
Chicken | LYZ-139C | Native Chicken lysozyme | Chicken Egg White | N/A | Full length native chicken egg white lysozyme |
- Involved Pathway
- Protein Function
- Interacting Protein
- LYZ Related Articles
LYZ involved in several pathways and played different roles in them. We selected most pathways LYZ participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Salivary secretion | AMY1B;LYZ1;CALM4;CALM1;PLCB2;PRKG1;DMBT1;ITPR3;ATP1A3 |
LYZ has several biochemical functions, for example, identical protein binding, lysozyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LYZ itself. We selected most functions LYZ had, and list some proteins which have the same functions with LYZ. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | DPP9;CHAF1A;ALDOB;PARK7;VIM;PYCARD;SEPT7;PLK4;ZNF212 |
lysozyme activity | LYZ1;LYZL6;LYGL1;CHIA;SPACA5;LYZ;LYG1;LYG2;LYZ2 |
LYZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYZ here. Most of them are supplied by our site. Hope this information will be useful for your research of LYZ.
IKBKB; USP1; NME2; VHL; KHK; CNBP; NFKBIB; TRIP6; LRRK1; PARP11; WRAP73; USP25; gpmI; midostaurin; ssrna_ac
- Q&As
- Reviews
Q&As (5)
Ask a questionSome research suggests that LYZ may have potential in treating gastrointestinal infections, but more studies are needed.
While LYZ has antibacterial properties, it is not typically used to treat viral infections like the common cold.
LYZ is used in the food industry as a natural preservative to prevent the growth of bacteria in various food products.
LYZ protein has several clinical applications, including in the field of medicine and biotechnology.
LYZ therapy is generally considered safe, but there may be rare allergic reactions or side effects in some individuals.
Customer Reviews (3)
Write a reviewwhen employed in Western Blotting experiments, the LYZ protein consistently generates sharp and well-defined protein bands, enabling precise visualization and analysis of protein expression.
I am extremely pleased with the quality of the LYZ protein as it perfectly fulfills my experimental requirements.
This protein exhibits exceptional purity and reliability, ensuring accurate and reproducible results in my assays.
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