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LYZ

  • Official Full Name

    lysozyme

  • Overview

    The acronym ANCA (Antineutrophil Cytoplasmic Autoantibodies) is defined by an accumulation of autoantibodies with specificity against different granulocytic, monocytic and probably endothelial cytoplasmic antigens. PR3 and MPO are well defined as reliable serological markers for a definite group of primary systemic vasculitides (PSV), which were also named ANCA associated vasculitides (AAV). The occurrence of AAV is clearly higher than supposed. The incidence is 1.5 per 1000 and in the group of older persons nearly 5 per 1000. The clinical appearance of the AAV is characterized through manifestations in lung, kidney and respiratory tract. In the last years, newer investigations discovered and characterised a couple of new pANCA antigens: Elastase, Cathepsin G, Lysozyme and Lactoferrin. Up to now, ANCA screening has been done with immunofluorescence techniques, but often there have been difficulties in the evaluation and in clinical findings. Therefore, the results have to be scrutinised with counter examinations on other cells or in other test systems like ELISA. Moreover it was not possible to differentiate the single cANCA and pANCA antigens.<br/>1. Proteinase 3<br/>The major antigen for the cANCA reactivity is the neutral serine protease 3 (synonyms: p29, AGP7, Wegener autoantigen), which belongs to the Trypsin/Chymotrypsin family. In 1988 several groups showed that the antigen is a protein with a molecular weight of 29 kDa. PR3 was already described in 1973 by Ohlsson and Olsson under the name neutrophile collagenase. In the meantime it seams certain, that autoantibodies against PR3 are highly specific as serological marker for the diagnosis of Wegener's granulomatosis (specificity: initial phase 50%, generalization phase >90%).Moreover there is a correlation between the concentration of the autoantibodies and the disease activity.<br/>2. Myeloperoxidase<br/>Myeloperoxidase is the major antigen in nearly 60% of the pANCA findings. The occurrence of autoantibodies against MPO is classified as relevant marker for the rapid progressive nephritis. Moreover these antibodies occur in 70-90% in all patients with serious kidney injury. Over and about they have also been detected at the Churg-Strauss-Syndrom (CSS), Microscopic Polyangiitis (MPA) and other vasculitis diseases. The concentration of the autoantibodies correlates well with the disease activity of MPA. MPA is also characterised by clinical manifestations of lung, kidney and respiratory tract, but these manifestations are, in contrast to WG, not granulomatous. However, these antibodies have, in contrast to the high specificity of PR3 anti-bodies for WG, a minor specificity of 60% in the diagnosis of MPA. The absence of autoantibodies against MPO and PR3, by simultaneous detection of ANA can be used as a tool for differential diagnosis between AAV and SLE induced vasculitis.<br/>3. BPI<br/>Bactericidal permeability-increasing protein, BPI is a membrane-located protein that is classed as an ANCA-Antigen of polymorph-nuclear granulocytes and monocytes that bind endotoxin. Its autoantibodies are now classified as cANCA. Due to BPIs high affinity to lipopolysaccharides its antimicrobial effect against Gram-negative bacteria is significant. BPI is cleaved and thus inactivated by using Elastase or other serine protease. Autoantibodies against BPI are above all detected in chronically infectious intestinal diseases such as Morbus Crohn or colitis ulcerosa. In contrast to anti-MPO and anti-PR3 autoantibodies, those against BPI seem not to have any association with vasculitis.<br/>4. Elastase<br/>Elastase is a serine protease with a sequence homology of 54% to that of proteinase 3. It occurs mainly in polymorph-nuclear neutrophil granulocytes (PMN), in macrophages and endothelial cells. The dismantling of proteoglycans by neutrophiles is mainly due to Elastase's proteolytic activity. Furthermore, Elastase participates decisively in tissue destruction connected with emphysemas and rheumatoid arthritis. Autoantibodies against this antigen are generally associated with inflammatory rheumatic disorders, e.g. rheumatoid arthritis and vasculitis.<br/>5. Cathepsin G<br/>The cathepsins belong to a group of intracellular proteases mainly found in lysosomes, especially of the spleen, the liver and the kidney. Cathepsin G is a serine protease and a further pANCA antigen. It participates to a great part in the destruction of osteoid tissue as of its hydrolytic properties. The autoantibodies against Cathepsin G occur mainly in collagenosis and other related inflammatory rheumatic diseases, e.g. SLE, Sj?gren′s syndrome and Felty's syndrome.<br/>6. Lysozyme<br/>Lysozyme is a glycosidase, which decomposes the glycosidic bond between C-1 of MNAc and C-4 of GlcNAc. Lysozyme is localised in the azurophilic as well as in the specific granules of neutrophils and in extracellular liquid compartments like tears and salivary, where it spreads out his antimicrobial activities against invading bacteria. LZ belongs also to the pANCA and autoantibodies against Lysozyme occur in higher frequency in rheumatoid vasculitis and inflammatory bowel disease like colitis ulcerosa.<br/>7. Lactoferrin<br/>Lactoferrin (LF) is an iron-binding protein, which occurs in high concentrations in secretions at mucosa surfaces, in tears and in milk. LF also resides in the specific granules of polymorphnuclear neutrophil leukocytes (PMN) and becomes exocytosed upon PMN activation. During active inflammatory disease, raised serum levels of LF can be measured. The physiological antimicrobial effect of Lactoferrin depends on its iron-binding capacity, because most of the bacteria require iron for their own physiological pathways. LF inhibits myelopoiesis, prevents complement activation and prevents the formation of hydroxyl radicals. It is quite possible that LF has several important roles, like secretory IgA, as a non-specific antiphlogistic defence factor at mucosal surfaces. LF belongs to the pANCA, depending on the redistribution from the granules toward the nuclei, upon ethanol fixation. Autoantibodies against Lactoferrin occur in higher frequency in patients with rheumatoid vasculitis (RV), colitis ulcerosa (CU) and primary sclerosing cholangitis (PSC).
  • Synonyms

    LYZ; lysozyme; lysozyme (renal amyloidosis); lysozyme C; renal amyloidosis; 1,4-beta-N-acetylmuramidase C; LZM;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Bovine
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Lophura Leucomelanos
  • Rhesus Macaque
  • Zebrafish
  • Chicken Egg
  • Chicken egg white
  • Chicken Egg White
  • E.coli
  • HEK293
  • Human Blood
  • Human Neutrophil
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Rice Grain
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • SUMO
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LYZ-64H Active Recombinant Human Lysozyme Rice Grain N/A
Human LYZ-04H Active Recombinant Human Lysozyme N/A
Human LYZ-249H Active Native Human Lysozyme Human Neutrophil N/A
Human LYZ-29007TH Active Native Human LYZ Human Blood N/A 130 amino acids
Human LYZ-5785H Recombinant Human LYZ protein, His-tagged E.coli His Cys24~Gln144 (Accession# P61626)
Human LYZ-275H Recombinant Human LYZ protein, His-tagged HEK293 His Lys19-Val148
Human LYZ-1033H Recombinant Human LYZ, MYC/DDK-tagged, 13C & 15N Labeled HEK293 Myc/DDK
Human LYZ-4580HCL Recombinant Human LYZ 293 Cell Lysate HEK293 N/A
Human LYZ-5316H Native Human Lysozyme(salivary) Human Blood N/A
Human LYZ-4533H Recombinant Human LYZ Protein, GST-tagged Wheat Germ GST
Human LYZ-27700TH Native Human LYZ Human Neutrophil N/A
Human LYZ-3196H Recombinant Human LYZ protein, His-SUMO-tagged E.coli His-SUMO 19-148aa
Human LYZ-2582HFL Recombinant Full Length Human LYZ, Flag-tagged Mamanlian cells Flag
Human LYZ-4478H Recombinant Human LYZ Protein (Lys19-Val148), C-His tagged Mammalian cells C-His Lys19-Val148
Human LYZ-3414H Recombinant Human LYZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LYZ-6038HF Recombinant Full Length Human LYZ Protein, GST-tagged In Vitro Cell Free System GST 148 amino acids
Human LYZ-3414H-B Recombinant Human LYZ Protein Pre-coupled Magnetic Beads HEK293
Human LYZ-4479H Recombinant Human LYZ Protein (Lys19-Val148), N-His tagged E.coli N-His Lys19-Val148
Bovine LYZ-05B Recombinant Bovine LYZ protein, His-tagged E.coli His Gly18~Leu147
Gallus gallus (Chicken) LYZ-683G Natural Gallus gallus (Chicken) domesticus allergen 4 (LYZ) protein Chicken egg white
Lophura Leucomelanos LYZ-1940L Recombinant Lophura Leucomelanos LYZ Protein (1-129 aa), His-SUMO-tagged E.coli His/SUMO 1-129 aa
Rhesus Macaque LYZ-2612R Recombinant Rhesus monkey LYZ Protein, His-tagged Mammalian Cell His
Rhesus Macaque LYZ-2432R-B Recombinant Rhesus Macaque LYZ Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LYZ-2432R Recombinant Rhesus Macaque LYZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish LYZ-9402Z Recombinant Zebrafish LYZ Mammalian Cell His
Chicken LYZ-65E Lysozyme From Chicken Eggs (Food Grade) Chicken Egg N/A
Chicken LYZ-6833C Recombinant Chicken LYZ Mammalian Cell His
Chicken LYZ-5784C Recombinant Chicken LYZ protein, His-tagged E.coli His Lys19~Leu147
Chicken LYZ-1501C Recombinant Chicken LYZ protein E.coli N/A 19-147aa
Chicken LYZ-139C Native Chicken lysozyme Chicken Egg White N/A Full length native chicken egg white lysozyme
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LYZ Related Articles

LYZ involved in several pathways and played different roles in them. We selected most pathways LYZ participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Salivary secretionAMY1B;LYZ1;CALM4;CALM1;PLCB2;PRKG1;DMBT1;ITPR3;ATP1A3

LYZ has several biochemical functions, for example, identical protein binding, lysozyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LYZ itself. We selected most functions LYZ had, and list some proteins which have the same functions with LYZ. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingDPP9;CHAF1A;ALDOB;PARK7;VIM;PYCARD;SEPT7;PLK4;ZNF212
lysozyme activityLYZ1;LYZL6;LYGL1;CHIA;SPACA5;LYZ;LYG1;LYG2;LYZ2

LYZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYZ here. Most of them are supplied by our site. Hope this information will be useful for your research of LYZ.

IKBKB; USP1; NME2; VHL; KHK; CNBP; NFKBIB; TRIP6; LRRK1; PARP11; WRAP73; USP25; gpmI; midostaurin; ssrna_ac

Zhang, CJ; Wang, YZ; et al. Silica-based surface molecular imprinting for recognition and separation of lysozymes. ANALYTICAL METHODS 6:8584-8591(2014).
Omer, M; Park, SY; et al. Preparation of QP4VP-b-LCP liquid crystal block copolymer and its application as a biosensor. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:5369-5378(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can LYZ be used to treat gastrointestinal infections? 05/25/2021

Some research suggests that LYZ may have potential in treating gastrointestinal infections, but more studies are needed.

Can LYZ be used to treat common colds? 03/03/2020

While LYZ has antibacterial properties, it is not typically used to treat viral infections like the common cold.

How is LYZ protein used in the food industry? 07/05/2019

LYZ is used in the food industry as a natural preservative to prevent the growth of bacteria in various food products.

What are the clinical applications of LYZ protein? 02/17/2019

LYZ protein has several clinical applications, including in the field of medicine and biotechnology.

Are there any side effects associated with LYZ therapy? 08/17/2018

LYZ therapy is generally considered safe, but there may be rare allergic reactions or side effects in some individuals.

Customer Reviews (3)

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Reviews
07/21/2022

    when employed in Western Blotting experiments, the LYZ protein consistently generates sharp and well-defined protein bands, enabling precise visualization and analysis of protein expression.

    01/13/2020

      I am extremely pleased with the quality of the LYZ protein as it perfectly fulfills my experimental requirements.

      03/26/2018

        This protein exhibits exceptional purity and reliability, ensuring accurate and reproducible results in my assays.

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