• Official Full Name
  • melanoma antigen family A, 2
  • Background
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
  • Synonyms
  • MAGEA2; melanoma antigen family A, 2; MAGE2; melanoma-associated antigen 2; cancer/testis antigen family 1; member 2; CT1.2; MAGEA2A; MAGE-2 antigen; melanoma antigen 2; cancer/testis antigen 1.2; cancer/testis antigen family 1, member 2; MAGEA2B; MGC1319
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAGEA2, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human MAGEA2 293 Cell Lysate

Protein Function

MAGEA2 has several biochemical functions, for example, histone deacetylase binding, protein binding, repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEA2 itself. We selected most functions MAGEA2 had, and list some proteins which have the same functions with MAGEA2. You can find most of the proteins on our site.
Related Protein
Function histone deacetylase binding
Related Protein SKOR2; TOP2A; HIST1H1B; KLF4; SP2; TAL1; RAD9A; MAGEA1; RBBP4; TFAP4
Function protein binding
Related Protein TOM1L1; ZNF205; JUNB; PRIMPOL; POU3F3; CYC1; UBA5; SSTR3; MRPL48; CUL4B
Function repressing transcription factor binding
Function ubiquitin protein ligase binding
Related Protein TUBA1B; RNF31; ANKRD32; GPR19; MAGEA2B; H2-AB1; RANGAP1; C10orf46; IKBKG; UBE2G1B

Interacting Protein

MAGEA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEA2.
TP53; TRIM28; HDAC3; UBE2H; ubiq_human; UBA1