The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
MAP7; microtubule-associated protein 7; ensconsin; E MAP 115; EMAP115; Epithelial microtubule associated protein of 115 kDa; MAP 7; Microtubule associated protein 7; MAP-7; epithelial microtubule-associated protein of 115 kDa; dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115)); E-MAP-115; ste; mshi; mste; R75000
MAP7 has several biochemical functions, for example, receptor binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP7 itself. We selected most functions MAP7 had, and list some proteins which have the same functions with MAP7. You can find most of the proteins on our site.
Function receptor binding
Related Protein NTF7; FGF8B; HFE; BLK; ANKRD13C; LGI1; PECI; SLC9A3R1; C3; PTK2AB
Function structural molecule activity
Related Protein MATR3; SEPT5; LAMB2; TUBB5; MAP7D1B; EVPL; VCLA; SPRR2A; CYT1; PLP1
MAP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP7.
Falcone, S; Roman, W; et al. N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy. EMBO MOLECULAR MEDICINE 6:1455-1475(2014).
de Oliveira, PSN; Cesar, ASM; et al. Identification of genomic regions associated with feed efficiency in Nelore cattle. BMC GENETICS 15:-(2014).