|Official Full Name||methyl-CpG binding domain protein 5|
|Background||This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.|
|Synonyms||MBD5; methyl-CpG binding domain protein 5; methyl-CpG-binding domain protein 5; FLJ11113; KIAA1461; methyl-CpG-binding protein MBD5; MRD1; FLJ30517|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MBD5 involved in several pathways and played different roles in them. We selected most pathways MBD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
MBD5 has several biochemical functions, for example, NOT DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD5 itself. We selected most functions MBD5 had, and list some proteins which have the same functions with MBD5. You can find most of the proteins on our site.
|NOT DNA binding||XRCC4; SKIL; HIPK2; TINF2; MBD5; NFIB|
|chromatin binding||ARNTL1B; FEZF2; PRMT6; ERCC6; KLF6A; TOX2; POLA1; JARID2B; NUPR1; SKI|
MBD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD5.
APC; mexB; vgrG5; epd; flgE; chi36; yqgS; mdlB6; fadL; acrA1; lipB; KIAA1549; ureC