• Official Full Name
  • methyl-CpG binding domain protein 5
  • Background
  • This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
  • Synonyms
  • MBD5; methyl-CpG binding domain protein 5; methyl-CpG-binding domain protein 5; FLJ11113; KIAA1461; methyl-CpG-binding protein MBD5; MRD1; FLJ30517
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBD5, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MBD5 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human MBD5 cell lysate

Protein Function

MBD5 has several biochemical functions, for example, NOT DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD5 itself. We selected most functions MBD5 had, and list some proteins which have the same functions with MBD5. You can find most of the proteins on our site.
Related Protein
Function NOT DNA binding
Related Protein SKIL; MBD5; TINF2; NFIB; HIPK2; XRCC4
Function chromatin binding
Related Protein SMC3; ZNF143; PARP1; POLE; SIRT7; PHF13; TLE4; BAHCC1; EWSR1A; MBD5

Interacting Protein

MBD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD5.
APC; mexB; vgrG5; epd; flgE; chi36; yqgS; mdlB6; fadL; acrA1; lipB; KIAA1549; ureC

MBD5 Related Articles

Xu, ZN; Yin, HS; et al. Electrochemical immunosensor for DNA methyltransferase activity assay based on methyl CpG-binding protein and dual gold nanoparticle conjugate-based signal amplification. SENSORS AND ACTUATORS B-CHEMICAL 192:143-149(2014).
Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).