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Official Full Name methyl-CpG binding domain protein 5
Background This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
Synonyms MBD5; methyl-CpG binding domain protein 5; methyl-CpG-binding domain protein 5; FLJ11113; KIAA1461; methyl-CpG-binding protein MBD5; MRD1; FLJ30517
    • Type:
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MBD5-1066HCL Recombinant Human MBD5 cell lysate N/A
    Human MBD5-764H Recombinant Human MBD5, His-tagged E.coli His
    Rhesus Macaque MBD5-2693R Recombinant Rhesus monkey MBD5 Protein, His-tagged Mammalian Cell His

    MBD5 involved in several pathways and played different roles in them. We selected most pathways MBD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    MBD5 has several biochemical functions, for example, NOT DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD5 itself. We selected most functions MBD5 had, and list some proteins which have the same functions with MBD5. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding ARNTL1B; FEZF2; PRMT6; ERCC6; KLF6A; TOX2; POLA1; JARID2B; NUPR1; SKI

    MBD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD5.

    APC; mexB; vgrG5; epd; flgE; chi36; yqgS; mdlB6; fadL; acrA1; lipB; KIAA1549; ureC

    Xu, ZN; Yin, HS; et al. Electrochemical immunosensor for DNA methyltransferase activity assay based on methyl CpG-binding protein and dual gold nanoparticle conjugate-based signal amplification. SENSORS AND ACTUATORS B-CHEMICAL 192:143-149(2014).
    Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).

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