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MDFIC

  • Official Full Name

    MyoD family inhibitor domain containing

  • Overview

    This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms

    MDFIC; MyoD family inhibitor domain containing; HIC; myoD family inhibitor domain-containing protein; I-mfa domain-containing protein;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse MDFIC-9659M Recombinant Mouse MDFIC Protein Mammalian Cell His
Mouse MDFIC-5428M Recombinant Mouse MDFIC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MDFIC-5428M-B Recombinant Mouse MDFIC Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MDFIC Related Articles

MDFIC involved in several pathways and played different roles in them. We selected most pathways MDFIC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MDFIC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MDFIC has several biochemical functions, for example, Tat protein binding, cyclin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDFIC itself. We selected most functions MDFIC had, and list some proteins which have the same functions with MDFIC. You can find most of the proteins on our site.

Function Related Protein
Tat protein bindingSMARCB1;MDFIC;NPM1;TRIM32;SMARCA4;GABARAPL1;DLL1;ACTB
cyclin bindingMDFIC;CDK5RAP3;INCA1;HDAC3;USP2;FBXW7;CUL3;CDK2;CDK12
protein bindingSPG11;MRPS31;FOXC1;RANBP2;ZGPAT;RNF175;RABGEF1;KCNN4;KIAA0319L
transcription factor bindingGATA3;MED1;FHL2;HDAC5;TRIB2;RB1;SMARCD3;DACT2;CAMTA2

MDFIC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDFIC here. Most of them are supplied by our site. Hope this information will be useful for your research of MDFIC.

Irak1

Zhang, LF; Zhou, X; et al. Genome Wide Screening of Candidate Genes for Improving Piglet Birth Weight Using High and Low Estimated Breeding Value Populations. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10:236-244(2014).
Gul, A; Ustek, D; et al. An Insertion Mutation in the MDFIC (MyoD Family Inhibitor Domain Containing) Gene Defines a Novel Autoinflammatory Syndrome Associated with Lymphedema. ARTHRITIS AND RHEUMATISM 63:S60-S60(2011).
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