mdfic
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  • Official Full Name
  • MyoD family inhibitor domain containing
  • Background
  • This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • MDFIC; MyoD family inhibitor domain containing; HIC; myoD family inhibitor domain-containing protein; I-mfa domain-containing protein;
Cat.#:MDFIC-9659MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MDFIC Protein
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Protein Function

MDFIC has several biochemical functions, for example, Tat protein binding, cyclin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDFIC itself. We selected most functions MDFIC had, and list some proteins which have the same functions with MDFIC. You can find most of the proteins on our site.
Function
Related Protein
Function Tat protein binding
Related Protein NPM1; DLL1; MDFIC; SMARCB1; TRIM32; GABARAPL1; ACTB; SMARCA4
Function cyclin binding
Related Protein CDK13; PTCH1; CDK5RAP3; CDK14; CDKN1A; FBXW7; USP2; MDFIC; PFTK1; CDK2
Function protein binding
Related Protein ZBTB22; HNRNPH1; EXOC3-AS1; HMGB1; NIF3L1; MINK1; BIN2; CARD9; UBE2H; PDS5A
Function transcription factor binding
Related Protein HMGA2; SNF8; PYDC3; PPARGC1A; HMGB1; PURA; DAXX; APBB1; AIP; NCOR2

Interacting Protein

MDFIC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDFIC here. Most of them are supplied by our site. Hope this information will be useful for your research of MDFIC.
Irak1

MDFIC Related Articles

Zhang, LF; Zhou, X; et al. Genome Wide Screening of Candidate Genes for Improving Piglet Birth Weight Using High and Low Estimated Breeding Value Populations. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10:236-244(2014).
Gul, A; Ustek, D; et al. An Insertion Mutation in the MDFIC (MyoD Family Inhibitor Domain Containing) Gene Defines a Novel Autoinflammatory Syndrome Associated with Lymphedema. ARTHRITIS AND RHEUMATISM 63:S60-S60(2011).