This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described.
MIPOL1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MIPOL1 itself. We selected most functions MIPOL1 had, and list some proteins which have the same functions with MIPOL1. You can find most of the proteins on our site.
Function protein binding
Related Protein TBKBP1; IL17A; RSPH1; ITGAL; ATF6B; LINGO1B; CAP2; MED30; RBPMS2B; RNPS1
MIPOL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MIPOL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MIPOL1.
PRPF31; EIF4E2; NEBL; MCM7; MAGEA6; ATP5O
MIPOL1 Related Articles
Butterfield, NC; Metzis, V; et al. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. DEVELOPMENT 136:3515-3524(2009).
Cheung, AKL; Lung, HL; et al. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, Mirror image polydactyly 1, in nasopharyngeal carcinoma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:14478-14483(2009).