NR5A1 Protein, nuclear receptor subfamily 5, group A, member 1

NR5A1

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NR5A1

Official Full Name nuclear receptor subfamily 5, group A, member 1
Background The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
Synonyms NR5A1; nuclear receptor subfamily 5, group A, member 1; ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR5A1-1361H Recombinant Human NR5A1, His-tagged E.coli His
    Human NR5A1-31465TH Recombinant Human NR5A1 Wheat Germ N/A
    Human NR5A1-368H Recombinant Human NR5A1 Mammalian Cell His
    Human NR5A1-3705HCL Recombinant Human NR5A1 293 Cell Lysate HEK293 N/A
    Human NR5A1-6099H Recombinant Human NR5A1 Protein, GST-tagged Wheat Germ GST
    Mouse NR5A1-10874M Recombinant Mouse NR5A1 Protein Mammalian Cell His
    Rat NR5A1-4073R Recombinant Rat NR5A1 Protein Mammalian Cell His
    Chicken NR5A1-6634C Recombinant Chicken NR5A1 Mammalian Cell His

    NR5A1 involved in several pathways and played different roles in them. We selected most pathways NR5A1 participated on our site, such as Developmental Biology, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology DLG3; CRMP1; PRDM14; MARK3; MED20; MYL12B; AP2B1; MEF2AA; DUSP7; FGF20A
    Gene Expression ADARB1A; SNAPC4; KHSRP; LSM11; NR2E3; ZFP28; NR5A1A; ZNF114; PTBP1A; SAP30L
    Generic Transcription Pathway ZNF729; ZNF597; COX18; ZNF426; TBX5A; GPR19; NR4A2A; NR1D2A; PPARAA; ZNF253
    Nuclear Receptor transcription pathway ESRRG; NR2F1A; NR5A1A; NR2C1; NR2C2; NR2F6A; NR5A1; NR6A1; NR2E1; ESR2B
    Nuclear Receptors RARGB; NR2F6; NR1H3; NR2E1; VDRB; NR1D2B; NR1D2; NR2C2; NR1I2; NR4A2A
    Ovarian Infertility Genes NR5A1; INHA; ZP3; MSH5; ZP2; SYNE2; DMC1; NRIP1; GJA4; DAZL
    Transcriptional regulation of pluripotent stem cells PRDM14; HIF3A; LIN28A; NR6A1; FOXD3; TDGF1; NR5A1; SALL4; POU5F3
    Wnt Signaling Pathway NetPath NR5A1; TCF4; SOX1; TAX1BP3; MARK2; BRD7; SALL1; BCL9; CRYBB2; MTAP1B

    NR5A1 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A1 itself. We selected most functions NR5A1 had, and list some proteins which have the same functions with NR5A1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF404; PROX1B; TOP3B; TAF1A; MECOM; ZBTB12; POU3F2A; ZNF705A; ZFP639; PHOX2BB
    RNA polymerase II distal enhancer sequence-specific DNA binding NFE2L2; TFAP2C; NR5A1; MEOX2; HOXB5; CREB1; TAL1; MSC; MED12; SIX3
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR5A1; NR4A2A; HNF4G; NR5A5; NR2F6B; NR2E3; RXRA; NR1I2; PPARDB; NR2F6A
    chromatin binding ZKSCAN3; NAP1L2; NFIA; EZH2; ASF1A; CCNT1; IFT74; PRKCBB; SLC30A9; MBD1
    enzyme binding PLAUR; BRCA1; SUPT5H; SLPI; HSPA1A; BACE1; TGFB1; SLC18A1; TTN; ACAT1
    phospholipid binding APOEB; PLA2G7; PTAFR; APOE; NBEAA; APOA1; PON1; VAMP2; SYTL4; OSBPL1A
    protein binding COPS4; SRC; MYBL2; KIF22; DEAF1; HNRNPA2B1; HBP1; FATE1; BARHL2; NQO2
    steroid hormone receptor activity VDR; RARA; PGR; NR1D1; RXRG; OR51E2; NR2F6B; NR1H4; NR4A3; NR2C2
    transcription coactivator activity SIX3; MKL1B; PML; NPAT; PER2; HIF3A; MNT; PSMC3; TGFB1I1; NR1H3
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding MEF2C; PURA; CEBPB; NR5A2; T; FOXP3; SNAI2; NKX2; CEBPA; OLIG2
    transcription regulatory region sequence-specific DNA binding NFKB1; NR5A1B; BTBD8; ZNF658; TBX18; NKX3; TFAP2A; ARNTL; GATA3; MKL1
    zinc ion binding NRAP; FBXO11; RNF122; PHEX; SLC30A7; ADAMTS12; MAP3K7IP3; MARCH6; ZDHHC15; TRIM64C

    NR5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A1.

    NCK2; NR0B1; PNRC2; 3bhs2_human_gene; FYN; NCK1; PIK3R1; CRK; GRB2; q7cfn3_yerpe; PROX1; cp11a_human_gene; star_human_gene; SMARCA5

    Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
    Sridevi, P; Chaitanya, RK; et al. FTZ-F1 and FOXL2 up-regulate catfish brain aromatase gene transcription by specific binding to the promoter motifs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1819:57-66(2012).
    Yokoyama, C; Komatsu, T; et al. Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1. HYBRIDOMA 28:113-119(2009).
    Falender, AE; Lanz, R; et al. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. ENDOCRINOLOGY 144:3598-3610(2003).

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