nr5a1
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  • Official Full Name
  • nuclear receptor subfamily 5, group A, member 1
  • Background
  • The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NR5A1; nuclear receptor subfamily 5, group A, member 1; ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3; steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor;
Cat.#:NR5A1-6099HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR5A1 Protein, GST-tagged
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Cat.#:NR5A1-1361HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR5A1, His-tagged
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Cat.#:NR5A1-31465THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NR5A1
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Cat.#:NR5A1-368HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NR5A1
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Cat.#:NR5A1-10874MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NR5A1 Protein
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Cat.#:NR5A1-4073RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR5A1 Protein
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Cat.#:NR5A1-6634CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR5A1
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Cat.#:NR5A1-3705HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR5A1 293 Cell Lysate
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Involved Pathway

NR5A1 involved in several pathways and played different roles in them. We selected most pathways NR5A1 participated on our site, such as Developmental Biology, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
GDF1; MYOG; TCF3B; LGI2A; CNTN6; MED6; PSPN; MYL9; DRAP1; COL9A3
Gene Expression
ZNF571; CLP1; ZNF264; SAP30BP; POLR3F; OSGEP; ZFP36L1A; ZNF615; MBD3B; ZNF2
Generic Transcription Pathway
COX14; SCO1; ZNF192; ZNF225; ZNF257; ZNF473; ZNF773; ZKSCAN4; CCNC; ZNF480
Nuclear Receptor transcription pathway
RORAA; NR1I3; NR2E1; PPARAA; NR2F1B; NRBP1; ESRRGA; RARAA; NR1I2; NR2C2AP
Nuclear Receptors
ROR1; NR2E1; NR2F1A; NR1H3; RARGB; NR5A1; NR1I3; RARG; NR2F6; RARGA
Ovarian Infertility Genes
INHA; DMC1; MSH5; DAZL; ZP2; ZP3; NRIP1; SYNE2; GJA4; NR5A1
Transcriptional regulation of pluripotent stem cells
NR5A1; TDGF1; HIF3A; FOXD3; SALL4; LIN28A; PRDM14; POU5F3; NR6A1
Wnt Signaling Pathway NetPath
ROR2; HIPK2; BRD7; TAX1BP3; ANKRD6; NR5A1; CSNK2A1P; TFAP2A; MARK2; MAP1B

Protein Function

NR5A1 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A1 itself. We selected most functions NR5A1 had, and list some proteins which have the same functions with NR5A1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RARB; ZNF83; RFX2; HOMEZA; ZFP653; TAF1L; ZNF358; PARP1; SMG6; ZNF556
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein MIXL1; GATA2; H3F3B; NFATC1; BACH1A; MED12; NFE2L2; RELA; REL; SPI1
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RXRB; NR2F5; PPARAB; PPARDB; STAT3; RXRA; RORA; RORCB; RORB; NR2F2
Function chromatin binding
Related Protein NKX6-1; NEUROG1; POLE; TICRR; SMARCE1; SKI; SMARCD1; FOXO1; TCF7L1B; PAX3
Function enzyme binding
Related Protein CYP2A4; STUB1; CAD; RYR2; Il6ra; BIRC7; MAT2B; KDM1A; GSTM7; BTG1
Function phospholipid binding
Related Protein SDPR; PLEKHA3; BAIAP2L2; SGIP1; PTAFR; TICAM2; FABP1; APOA5; LRBA; CPS1
Function protein binding
Related Protein HIST2H3C; XRCC6; SLBP; CYB5R1; TMED1; MAP3K5; SAMM50; HDC; PIK3CB; RPP38
Function steroid hormone receptor activity
Related Protein ESRRGB; NR0B2A; HNF4G; ESR2; NR1D1; NR1H4; NR5A1A; HNF4A; RXRGA; NR5A1B
Function transcription coactivator activity
Related Protein BRD7; MED31; NR1H3; SMARCD1; CARM1; BRCA1; THRAP3; MAGED1; JMY; POU2AF1
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein AHR; TLE4; HNF4A; TEAD2; OLIG2; FOXF1; ZFHX3; USF1; FOXC1; CIR1
Function transcription regulatory region sequence-specific DNA binding
Related Protein ARNTL1A; ARNTL; NR5A5; SFPQ; NR5A1B; TBX18; PER2; NKX3-1; TFAP2A; NFE2L2A
Function zinc ion binding
Related Protein TRIM65; LIG3; PHF7; MMP20; ADAMTS8; MMP14B; DIDO1; RNFT2; ZFAND2B; MMP23BB

Interacting Protein

NR5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A1.
NCK2; NR0B1; PNRC2; 3bhs2_human_gene; FYN; NCK1; PIK3R1; CRK; GRB2; q7cfn3_yerpe; PROX1; cp11a_human_gene; star_human_gene; SMARCA5

NR5A1 Related Articles

Li, MH; Wu, FR; et al. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. BIOLOGY OF REPRODUCTION 86:-(2012).
Sridevi, P; Chaitanya, RK; et al. FTZ-F1 and FOXL2 up-regulate catfish brain aromatase gene transcription by specific binding to the promoter motifs. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1819:57-66(2012).
Yokoyama, C; Komatsu, T; et al. Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1. HYBRIDOMA 28:113-119(2009).
Falender, AE; Lanz, R; et al. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. ENDOCRINOLOGY 144:3598-3610(2003).