pcbp4
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  • Official Full Name
  • poly(rC) binding protein 4
  • Background
  • This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This genes protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
  • Synonyms
  • PCBP4; poly(rC) binding protein 4; poly(rC)-binding protein 4; alphaCP 4 protein; LIP4; LYST interacting protein; MCG10; RNA binding protein MCG10; Alpha CP4; rCbinding protein 4; alpha-CP4; LYST-interacting protein; CBP
Cat.#:PCBP4-12416MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PCBP4 Protein
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Cat.#:PCBP4-3317RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PCBP4 Protein, His-tagged
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Cat.#:PCBP4-3401HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PCBP4 293 Cell Lysate
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Involved Pathway

PCBP4 involved in several pathways and played different roles in them. We selected most pathways PCBP4 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCBP4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Direct p53 effectors
DGCR8; PCBP4; PRDM1; RNF144B; BNIP3L; GDF15; TRIAP1; ZNF385A; BCL2L14; SCN3B

Protein Function

PCBP4 has several biochemical functions, for example, DNA binding, RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCBP4 itself. We selected most functions PCBP4 had, and list some proteins which have the same functions with PCBP4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RCOR3; SAP30; NFYAL; NKX3.2; POLR2A; FUS; SMAD6A; RBM5; ARID3C; PPARA
Function RNA binding
Related Protein ILF3A; THUMPD3; RPF1; IFIT11; ETF1; LRPPRC; FMR1; RPL28; FAU; RPP14
Function poly(A) RNA binding
Related Protein RPL23A; SAFB; EIF3H; DZIP3; RPL22; RPL3; RPLP0; RPS7; SEC61B; SFRS9

Interacting Protein

PCBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCBP4.
PCBP1; RNF138; QKI; RBFOX1

PCBP4 Related Articles

Wong, BW; Kuchnio, A; et al. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. TRENDS IN BIOCHEMICAL SCIENCES 38:3-11(2013).
Xia, M; He, H; et al. PCBP1 is required for maintenance of the transcriptionally silent state in fully grown mouse oocytes. CELL CYCLE 11:2833-2842(2012).