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PCBP4

  • Official Full Name

    poly(rC) binding protein 4

  • Overview

    This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This genes protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
  • Synonyms

    PCBP4; poly(rC) binding protein 4; poly(rC)-binding protein 4; alphaCP 4 protein; LIP4; LYST interacting protein; MCG10; RNA binding protein MCG10; Alpha CP4; rCbinding protein 4; alpha-CP4; LYST-interacting protein; CBP;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCBP4-3401HCL Recombinant Human PCBP4 293 Cell Lysate HEK293 N/A
Human PCBP4-5772H Recombinant Human PCBP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PCBP4-2001HFL Recombinant Full Length Human PCBP4 Protein, C-Flag-tagged Mammalian cells Flag
Human PCBP4-1616H Recombinant Human PCBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PCBP4-1616H-B Recombinant Human PCBP4 Protein Pre-coupled Magnetic Beads HEK293
Mouse PCBP4-12416M Recombinant Mouse PCBP4 Protein Mammalian Cell His
Mouse Pcbp4-4699M Recombinant Mouse Pcbp4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PCBP4-6534M Recombinant Mouse PCBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PCBP4-6534M-B Recombinant Mouse PCBP4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PCBP4-3317R Recombinant Rhesus monkey PCBP4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PCBP4-3135R Recombinant Rhesus Macaque PCBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCBP4-3135R-B Recombinant Rhesus Macaque PCBP4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PCBP4 Related Articles

PCBP4 involved in several pathways and played different roles in them. We selected most pathways PCBP4 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsPCBP4;CCNK;CTSD;S100A2;EPHA2;DUSP5;HIC1;SCN3B;EDN2

PCBP4 has several biochemical functions, for example, DNA binding, RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCBP4 itself. We selected most functions PCBP4 had, and list some proteins which have the same functions with PCBP4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF326;ZNF143;ATOH8;NR1H3;ZNF784;ONECUT1;DNAJB6;ZNF76;PARPBP
RNA bindingRPL7;RPP14;MARF1;YTHDC2;DUSP11;IFIT10;RPL24;RBM27;MIF4GDB
poly(A) RNA bindingGTPBP10;TTC6;ERI3;AKAP17A;SERPINH1;LUC7L2;DDX10;PDCD11;PDIA4

PCBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCBP4.

PCBP1; RNF138; QKI; RBFOX1

Wong, BW; Kuchnio, A; et al. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. TRENDS IN BIOCHEMICAL SCIENCES 38:3-11(2013).
Xia, M; He, H; et al. PCBP1 is required for maintenance of the transcriptionally silent state in fully grown mouse oocytes. CELL CYCLE 11:2833-2842(2012).
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