• Official Full Name
  • protocadherin alpha 7
  • Background
  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
  • Synonyms
  • PCDHA7; protocadherin alpha 7; CNRS4; protocadherin alpha-7; CNR4; CRNR4; KIAA0345 like 7; ortholog to mouse CNR4; PCDA7_HUMAN; PCDH alpha 7; PCDH-alpha-7; KIAA0345-like 7; OTTHUMP00000223679; CNRN4; PCDH-ALPHA7
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PCDHA7

PCDHA7 Related Articles

Wang, KH; Lin, CJ; et al. Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV. CANCER MEDICINE 4:43-55(2015).
Asad, M; Wong, MK; et al. FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. CELL DEATH & DISEASE 5:-(2014).