ppp3cb
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, beta isozyme
  • Background
  • Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene.
  • Synonyms
  • PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme; CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta); serine/threonine-pro
Cat.#:PPP3CB-13267MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3CB Protein
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Cat.#:PPP3CB-4640RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CB Protein
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Cat.#:PPP3CB-2226CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3CB
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Cat.#:PPP3CB-2579ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CB
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Involved Pathway

PPP3CB involved in several pathways and played different roles in them. We selected most pathways PPP3CB participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
HRASB; FGF6A; MAPK10; HSPA8; FGF1; STK3; MKNK2A; MAP4K4; HSPB1; MKNK2
Calcium signaling pathway
ORAI2; ITPKC; PHKA1; ADORA2AB; SPHK1; ADRB2; TACR1B; CAMK2B1; TACR3; CHRM2
cGMP-PKG signaling pathway
IRS4; CALML3; BNP; PLCB2; ATP2B1; ATP1B3; SLC8A1; AKT2; PLCB4; PIK3CA
Oocyte meiosis
SLK; AURKA; ESPL1; PPP2R5E; YWHABL; ADCY2B; CALM2A; MAPK12B; ANAPC13; PPP2R5EA
Apoptosis
DCC; HIST1H1E; PRKAR2A; Casp3; PRKACA; CYCSB; CDK5RAP2; PRKAR1B; TICAM1; DIABLO
Wnt signaling pathway
PPP3R1B; PPP3CCB; PRICKLE2B; RHOA; CAMK2D; RAC3; SMAD3; PPP3CCA; SKP1; DKK2
Axon guidance
SPTA1; PLXNB2; COL6A1; EPHB2; ITGB1; GNAI3; DLG3; SEMA6D; DUSP6; TRPC5
VEGF signaling pathway
MAP2K1; RAC1A; NFATC2; PIK3R5; CDC42L2; CASP9; PTGS2A; PPP3CCA; PPP3R1B; SHC2
Osteoclast differentiation
NFATC2; CSF1; PPP3R1; LCP2; SPI1; IFNG; IFNB1; NCF4; TEC; PIK3R1
Natural killer cell mediated cytotoxicity
PLCG1; KLRD1; SHC2; SYK; PPP3CB; SOS1; Raet1c; TNF; ARAF; CD48
T cell receptor signaling pathway
RELA; MUC1; MAPK9; NFKBIA; CD3G; GRB2; FOS; AKT2; PAK7; DEF6A
B cell receptor signaling pathway
KRAS; NFKBIA; IKBKB; RAF1; PTPN6; RAC2; VAV2; BCL10; MAP2K2; LCP2A
Long-term potentiation
GRM5; PPP3CA; PLCB1; PRKCA; ITPR3; NRAS; RAP1A; RPS6KA6; MAPK3; PPP1CA
Glutamatergic synapse
PPP3R1; GRIN2A; PPP3CC; GRIA1; GNG7; GRIK3; ITPR1; PLD2; PLCB3; ADRBK2
Dopaminergic synapse
KIF5C; GNG4; SLC6A3; GRIA2; GNGT2; PPP2R5A; PLCB3; PPP2R5C; MAOB; GNGT1
Oxytocin signaling pathway
NRAS; KCNJ14; CACNG6; ROCK1; PLCB1; OXTR; GNAI2; PPP3CA; PIK3R3; CAMK2B
Glucagon signaling pathway
PLCB3; GYS1; ACACA; SMEK1; CAMK2D; PFKL; SMEK2; SIRT1; PRKAB1; ATF4
Renin secretion
PLCB3; GNAI1; NPR1; PPP3CB; GUCY1B3; PDE3A; CLCA3; PLCB2; CALML5; Ren1
Alzheimers disease
COX7B2; CASP12; TNFRSF1A; COX5A; BACE1; ATP5G3; PLCB2; MME; UQCRC2; COX4I1
Amyotrophic lateral sclerosis (ALS)
PRPH; PPP3CA; CYCS; MAPK14; GRIN2D; CASP12; GPX1; TRP53; NEFH; Casp3
Amphetamine addiction
CAMK2D; FOS; CREB3L1; STX1A; CREB3L3; PRKCA; PRKACB; DRD1A; TH; GRIN3B
Tuberculosis
STAT1; HLA-DQA2; CYCS; MAPK9; HLA-DRB3; LBP; PPP3CC; CAMP; HLA-DPA1; IFNA6
HTLV-I infection
WNT6; CCND3; VDAC1; PIK3CD; HLA-DMB; SMAD4; ITGAL; TNFRSF13C; XPO1; TGFB3

Protein Function

PPP3CB has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CB itself. We selected most functions PPP3CB had, and list some proteins which have the same functions with PPP3CB. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein ANXA5A; EFCAB5; PCDH1G11; KIAA0494; DGKG; SPOCK1; CRTAC1; RHOT2; MMP3; PVALB1
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein PPP3CB; CAMK2G; NETO2; PPP3R1
Function calmodulin binding
Related Protein CTH; MYH1B; CAMSAP1L1; IQGAP3; AKAP5; ITPKC; DDX5; NOS3; DAPK1; EEF2K
Function calmodulin-dependent protein phosphatase activity
Related Protein PPM1F; PPM1A; PPP3CA; PPP3CB
Function drug binding
Related Protein NAMPT; SETD6; CNR1; CHRNB4; PDE10A; MTOR; PDE4D; ABP1; DRD1A; HTR1B
Function enzyme binding
Related Protein TP53; DIS3L; CA; JUND; CLSTN2; PLCE1; FOXO4; ZFHX3; TSPAN17; HSPA1A
Function hydrolase activity
Related Protein ATP2A2A; CHD8; TMPRSS11F; Gzmg; CMBL; ABHD2B; ADAMTS16; ATP1A3A; Gzmd; CES1C
Function metal ion binding
Related Protein ACAP2; SP9; TRIM35-24; KLF2A; SEC23IP; ZNF683; VEZF1; CYP2AA6; RFESD; JADE1
Function phosphoprotein phosphatase activity
Related Protein PTPRDB; PTPN2A; PTPN4A; PPM1BA; PPTC7A; CTDNEP1; CDC25D; PPM1AB; PPP1R3B; PPP1CAB
Function protein binding
Related Protein L3MBTL4; TFB1M; MAPK8IP3; NXF1; C22orf29; TRIM29; MED4; C1orf38; PAIP2; IRS2
Function protein dimerization activity
Related Protein TCF23; ATOH8; HER3; HER8.2; CLOCKA; ARNTL1B; NPAS1; TCF15; TCF3A; STX2
Function protein heterodimerization activity
Related Protein GTF2A2; TERF1; BAXB; IL12A; PDSS2; BIK; ADRA1B; SMC2; PPP3CA; DLG4B
Function protein phosphatase 2B binding
Related Protein SLC9A1; AKAP1; BAD; MYOZ2; ATP2B4; SOD1; AKAP5; PPP3CB
Function protein serine/threonine phosphatase activity
Related Protein PPM1LB; DUSP23A; PPM1K; PPP1R3C; PPA2; PDP2; PTEN; PPP6C; PPM1F; PPM1DB

Interacting Protein

PPP3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CB.
Akap5; NFATC1; Akap6; Ppp3r1; Hmga2; Ywhae; Dlg4; Map3k5

PPP3CB Related Articles

Vasu, S; McClenaghan, NH; et al. Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia. ISLETS 5:170-177(2013).
Polovkova, OG; Makeeva, OA; et al. Expression Profiles of Calcineurin Pathway Genes in Myocardium in Relation to Ischemic Heart Remodeling in Humans. MOLECULAR BIOLOGY 47:382-388(2013).