ppp3cb
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, beta isozyme
  • Background
  • Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene.
  • Synonyms
  • PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme; CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta); serine/threonine-pro
Cat.#:PPP3CB-13267MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3CB Protein
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Cat.#:PPP3CB-4640RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CB Protein
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Cat.#:PPP3CB-2226CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3CB
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Cat.#:PPP3CB-2579ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CB
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Involved Pathway

PPP3CB involved in several pathways and played different roles in them. We selected most pathways PPP3CB participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF10; TGFB3; RASGRF2B; TGFBR1B; RPS6KA3B; MAP4K1; NFATC3; STMN1; CACNA1D; FGF6B
Calcium signaling pathway
NOS3; P2RX6; CAMK2D; PLCB2; PPP3R2; F2R; GNA14; TMEM8C; ADRB2; HTR2CL1
cGMP-PKG signaling pathway
ATP1A2; ATP2B1; MAP2K1; FXYD2; BDKRB2; GUCY1B3; ATP1B1; CREB3L1; ATP1A1; PIK3R1
Oocyte meiosis
PRKACAA; ANAPC13; PPP3R2; ADCY1A; INS1; PPP2R5C; CALM3A; CAMK2B; CCNE1; ITPR3
Apoptosis
HMGB2A; Casp3; PIK3R1; PIK3R3; IL1A; IRF2; BADB; TNFRSF10B; HIST1H1A; IRF2A
Wnt signaling pathway
PORCN; SFRP4; LRP6; WNT7B; DVL3A; WNT4A; RAC2; CCND1; TLE3A; RAC1A
Axon guidance
TRIO; COL4A3; ARPC4; ARHGEF28; LIMK2; SCN3A; COL6A2; SRGAP2; EFNA5; RASGEF1A
VEGF signaling pathway
PPP3R1; PIK3R3A; SHC2; AKT2; MAPK12B; SRC; PTK2AA; SPHK1; PIK3CG; HRASA
Osteoclast differentiation
TNF; TRAF6; TNFSF11; IL1R1; PIK3R1; RELA; IKBKG; LILRA4; PPP3CB; PIK3CD
Natural killer cell mediated cytotoxicity
IFNA7; MAP2K1; CD247; KLRC4-KLRK1; MAPK3; PPP3R1; PRF1; ITGB2L; PIK3R2; VAV3
T cell receptor signaling pathway
ICOS; MAP3K7; MAP2K7; PDPK1; RELA; PPP3CA; HRAS; MAP3K14; MAPK1; PIK3CD
B cell receptor signaling pathway
PTPN6; PIK3CG; PTPN18; IFITM1; PIK3R3; IKBKG; NFATC1; ARPC5; NFKBIA; PPP3CC
Long-term potentiation
PRKACA; PPP3R2; CAMK2A; RAF1; BRAF; GRIA2; PLCB1; CAMK2B; CALM3; CAMK2D
Glutamatergic synapse
PLCB3; GRIN3A; GNB4; GLS2; PPP3CA; GRIA2; GRIA1; GLS; GNB3; SLC1A3
Dopaminergic synapse
TH; CREB3L4; CAMK2G; MAPK12; PPP3CA; PPP1CA; CREB3L1; GNGT2; CAMK2D; PRKACA
Oxytocin signaling pathway
FOS; PRKAG2; NFATC3; RCAN1; CAMK1D; CALM4; CALM2; RYR2; PRKAB2; GNAS
Glucagon signaling pathway
PKM; CREB3L3; CPT1C; PRKAA2; CAMK2G; CALM3; CALM4; CALM1; CAMK2A; PLCB3
Renin secretion
AGTR1A; PTGER2; GNAQ; REN2; PTGER4; PPP3CC; PLCB3; GNAI2; LOC100328615; ACE
Alzheimers disease
HSD17B10; NDUFS4; GAPDH; GSK3B; NDUFB4; SDHD; PPP3CB; CDK5; COX7A2L; NAE1
Amyotrophic lateral sclerosis (ALS)
CASP9; TP53; GPX1; CCS; NEFM; PPP3R1; GRIA1; PPP3CA; GRIN1; CYCS
Amphetamine addiction
GRIA2; CALM1; GRIA1; GNAS; MAOB; PPP1CB; SLC14A2; ATF6B; CREB5; CAMK2B
Tuberculosis
CASP9; FCER1G; TGFB1; ATP6V0A2; NOS2; IFNGR1; ITGAX; IL1B; CALML3; BID
HTLV-I infection
SLC25A31; CDC27; TBPL1; MAP3K3; ETS2; NFKB1; SFPI1; PIK3R5; PTTG1; WNT11

Protein Function

PPP3CB has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CB itself. We selected most functions PPP3CB had, and list some proteins which have the same functions with PPP3CB. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein TNNC1B; ANXA2B; PLA2G2E; MYL12.1; DNASE1L2; NCS1A; PCDH2G28; CABP5; ANXA6; CDH20
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein NETO2; PPP3CB; CAMK2G; PPP3R1
Function calmodulin binding
Related Protein NOS2; MYH1E; SPHK1; NOS1; PHKB; KCNN1A; MARCKSL1; MYH7; MYLK2; NRGNA
Function calmodulin-dependent protein phosphatase activity
Related Protein PPM1A; PPM1F; PPP3CB; PPP3CA
Function drug binding
Related Protein CNR1; SRP54B; HTR2A; NR1I2; CHKA; DRD2; HTR2C; DHODH; GPR30; CHRNB4
Function enzyme binding
Related Protein MARCH6; MSH3; CTNNBL1; CBX3; IL6R; EIF2AK3; Alb; SIRT3; TARBP2; ZFHX3
Function hydrolase activity
Related Protein PPM1LA; SPO11; ACP5B; ZRANB1B; NUDT17; Gzmg; ABHD16A; TENC1; Casp3; PRSS28
Function metal ion binding
Related Protein ZFP36L3; ZNF592; ZBED2; FTR50; FAM164C; ADAP2; CSRP1B; KLF17; PDZRN3B; PXNA
Function phosphoprotein phosphatase activity
Related Protein PPM1AB; PTPRJA; DUSP9; PPM1LB; CDC14A; PTPN23A; PPM1H; CTDNEP1B; PPTC7; SSH1
Function protein binding
Related Protein STAP2; DYNAP; SPAG5; TMED1; NFYC; HSP90AA1.2; BMF; MID1IP1; SGOL1; HINFP
Function protein dimerization activity
Related Protein CLOCKB; STK3; LMLN; ZBED1; HER6; MTOR; MYO5A; HER13; SIM1A; HPSE
Function protein heterodimerization activity
Related Protein HIST1H2B7; TLR1; CHRNB4; GAD2; SYCP2; CAV1; ERBB3; GCLC; SIM2; NR4A2
Function protein phosphatase 2B binding
Related Protein AKAP1; SOD1; SLC9A1; PPP3CB; ATP2B4; AKAP5; BAD; MYOZ2
Function protein serine/threonine phosphatase activity
Related Protein ILKAP; PDP2; CDC14C; CDC14AB; PPM1BA; MTMR4; EPM2A; PPEF2; PPM1H; CDC14B

Interacting Protein

PPP3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CB.
Akap5; NFATC1; Akap6; Ppp3r1; Hmga2; Ywhae; Dlg4; Map3k5

PPP3CB Related Articles

Vasu, S; McClenaghan, NH; et al. Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia. ISLETS 5:170-177(2013).
Polovkova, OG; Makeeva, OA; et al. Expression Profiles of Calcineurin Pathway Genes in Myocardium in Relation to Ischemic Heart Remodeling in Humans. MOLECULAR BIOLOGY 47:382-388(2013).