ppp3cb
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, beta isozyme
  • Background
  • Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene.
  • Synonyms
  • PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme; CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta); serine/threonine-pro
Cat.#:PPP3CB-13267MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3CB Protein
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Cat.#:PPP3CB-4640RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CB Protein
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Cat.#:PPP3CB-2226CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3CB
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Cat.#:PPP3CB-2579ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CB
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Involved Pathway

PPP3CB involved in several pathways and played different roles in them. We selected most pathways PPP3CB participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PAK1; NFKB2; CACNG7; NTRK1; PPP3CC; PRKCA; CACNG2A; FGF20B; SRFA; MAP2K4A
Calcium signaling pathway
CCKBR; VDAC3; CYSLTR1; GRPR; HTR2A; DRD7; ADRB2; AVPR1B; HTR7; ADRB2B
cGMP-PKG signaling pathway
PIK3R2; PPP3CB; PLN; ATP1A1; BAD; SLC25A31; GUCY1B3; MAP2K1; PPP1CA; PIK3R1
Oocyte meiosis
CUL1; FBXW11; CTH1; CALM1B; CALM1A; PRKACBB; RPS6KA3; CALM1; PPP3R1; CCNE1
Apoptosis
CAPN2; E2F1; HIST1H1D; ADD1; BAXA; TNFRSFA; TICAM1; HIST1H1A; DCC; BNIP3LB
Wnt signaling pathway
SKP1; NKD2; INVS; WNT7A; CAMK2G1; TLE3A; PPP3CC; MAPK8; BAMBIB; WNT2BB
Axon guidance
PAK7; FGF10B; EPHB4A; PAQR3A; UNC5A; COL9A1; CSNK2A1; CDK5; ST8SIA2; EPHA2A
VEGF signaling pathway
PPP3CCA; MAP2K1; SPHK1; PPP3R1B; NRAS; SPHK2; MAPK12B; RAC3A; VEGFAA; RAC3B
Osteoclast differentiation
RELB; MAPK8; LCK; IL1R1; NCF1; RAC1; RELA; SIRPG; STAT2; IFNG
Natural killer cell mediated cytotoxicity
KLRD1; H60a; PIK3CD; KLRC2; RAET1D; Ifna15; PLCG2; SOS1; KRAS; GRB2
T cell receptor signaling pathway
CD8B1; CABIN1; ICOS; MAP3K7; CD28; NRAS; CBLC; GSK3B; NFKB1; PPP3R2
B cell receptor signaling pathway
NFKBIB; MAP2K1; RAC3; CD81; INPP5D; BLK; ITK; STAP1; PIK3R1; MAP2K2
Long-term potentiation
ITPR1; PPP3CB; GRIN2C; CALM1; HRAS; ATF4; GRIN2D; PRKACG; RPS6KA3; PLCB4
Glutamatergic synapse
PPP3R1; GNG2; GRIN2B; GNG8; GLUL; PLA2G4A; GLS2; GRIA1; SLC17A6; SLC1A1
Dopaminergic synapse
CALM1; GRIA3; GRIA4; MAOA; MAPK12; GNG11; KCNJ5; CAMK2D; PLCB2; PPP1CC
Oxytocin signaling pathway
PRKCB; PLCB3; CACNG6; ELK1; KRAS; CACNG4; CAMK4; PRKAB1; GNAI3; HRAS
Glucagon signaling pathway
PLCB3; PYGM; SIRT1; GNAS; ITPR1; PCK1; PPP3R1; GNAQ; CREB3L2; CRTC2
Renin secretion
PLCB3; LOC100328615; PPP3CA; PDE3A; AGTR1B; GNAI1; Ren1; PRKACG; REN; PDE1B
Alzheimers disease
SDHD; EIF2AK3; NDUFS3; COX6B2; NDUFB1; PPP3R1; MME; NDUFA3; NDUFS1; FADD
Amyotrophic lateral sclerosis (ALS)
PPP3CB; SOD1; CAT; PPP3CC; MAPK14; CYCS; NEFL; GRIN2D; BAX; NEFH
Amphetamine addiction
CAMK2D; ATF2; CREB3L4; GRIA1; CREB3L3; GRIN3B; GRIN2A; DRD1; PPP3R1; HDAC1
Tuberculosis
IL1A; H2-AB1; MAPK3; KSR1; RHOA; IL10RB; IFNA5; ITGAX; CLEC4E; AKT2
HTLV-I infection
PRKACA; CDC23; ETS1; PPP3R2; KAT2A; ICAM1; SLC25A4; XBP1; ANAPC4; APC

Protein Function

PPP3CB has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CB itself. We selected most functions PPP3CB had, and list some proteins which have the same functions with PPP3CB. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PVALB7; CALR; C2CD4B; GM5077; CLGN; NCALDB; SYT1; CALB1; PKD1L2; S100U
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein PPP3CB; NETO2; PPP3R1; CAMK2G
Function calmodulin binding
Related Protein SPTBN1; PLCB3; MAP2; ORAI1; KCNQ1; MYH1; ADD2; RIT1; KCNN1; MAPKAPK2B
Function calmodulin-dependent protein phosphatase activity
Related Protein PPP3CA; PPP3CB; PPM1A; PPM1F
Function drug binding
Related Protein DRD1; FOLR1; CHRM1; CHRNB4; PYGL; ATP5O; P2RX2; DRD3; HMGB2; HTR2C
Function enzyme binding
Related Protein YWHAB; BACE1; MDM2; LYN; U2AF2; CBS; NCOA1; UGT1A6; CTNNBL1; KDM4C
Function hydrolase activity
Related Protein ATP2B2; PPM1DB; ENPP2; Aadacl3; IHHA; ABHD16A; PTPRK; CNOT6; HAGHL; IDI1
Function metal ion binding
Related Protein B3GNT1; CA14; ZDHHC6; NPSN; XPNPEP2; ADCY7; JAZF1B; MYLIPB; ZMIZ2; DMRT3A
Function phosphoprotein phosphatase activity
Related Protein PTPN4B; PTPRK; PHLPP1; PTPRFB; PTPN23A; PPP1CBL; DUSP10; PTPN11B; PPM1AB; PTPRU
Function protein binding
Related Protein ORAI1; ACSS1; CCDC108; PGAP2; EXOSC10; PSMC2; DYDC1; TCF12; DIAPH1; OSR2
Function protein dimerization activity
Related Protein HER3; TFAP2A; NCOA1; TFE3B; HES4; AHRRA; BHLHA15; TCF15; RIMKLB; EPAS1B
Function protein heterodimerization activity
Related Protein INHA; TBX18; ANO9A; POU5F3; H3F3A; CD3E; GABPB2; H3F3B.1; KCNB1; GRIN1
Function protein phosphatase 2B binding
Related Protein PPP3CB; SLC9A1; ATP2B4; SOD1; AKAP1; AKAP5; MYOZ2; BAD
Function protein serine/threonine phosphatase activity
Related Protein PPM1DB; PPP4C; CDC14A; PPM1K; PPM1AA; PPM1H; PPP2R5D; PPP2R2A; UBLCP1; PPM1L

Interacting Protein

PPP3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CB.
Akap5; NFATC1; Akap6; Ppp3r1; Hmga2; Ywhae; Dlg4; Map3k5

PPP3CB Related Articles

Vasu, S; McClenaghan, NH; et al. Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia. ISLETS 5:170-177(2013).
Polovkova, OG; Makeeva, OA; et al. Expression Profiles of Calcineurin Pathway Genes in Myocardium in Relation to Ischemic Heart Remodeling in Humans. MOLECULAR BIOLOGY 47:382-388(2013).