ppp3cb
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  • Official Full Name
  • protein phosphatase 3, catalytic subunit, beta isozyme
  • Background
  • Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene.
  • Synonyms
  • PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme; CALNB, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta); serine/threonine-pro
Cat.#:PPP3CB-13267MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP3CB Protein
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Cat.#:PPP3CB-4640RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP3CB Protein
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Cat.#:PPP3CB-2226CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP3CB
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Cat.#:PPP3CB-2579ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP3CB
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Involved Pathway

PPP3CB involved in several pathways and played different roles in them. We selected most pathways PPP3CB participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K3; RAF1A; PPP3R2; CDC42L; MEF2CB; TGFB1A; GNA12; FGF20; CACNA1SB; PPP3CCB
Calcium signaling pathway
GNAQ; ADORA2AA; TACR2; P2RX4A; NTSR1; PLCG2; PPIFB; P2RX5; PRKACB; PDE1B
cGMP-PKG signaling pathway
MEF2D; NFATC4; PLCB2; CALM1; GUCY1B3; Adcy4; CREB3L2; MYLK; PPP3CA; CREB3L3
Oocyte meiosis
PRKACAB; CAMK2G1; PPP2R5E; ANAPC13; INS1; CDC23; RPS6KA3B; SKP1; CALML3; PPP2R5D
Apoptosis
IL3; PRKAR1A; IRF2; CLSPN; DFFB; RNF8; XIAP; CASP4; AKT3A; ENDOG
Wnt signaling pathway
PLCB2; WNT2BA; FZD3B; BAMBI; TCF7L2; TBL1X; INVS; FRAT2; FZD9; PPP3R1B
Axon guidance
CFL1; NTN1B; NETO2; SPRED1; DPYSL5B; ARHGEF12; SPRED2; SCN3B; EPHA10; RHOGA
VEGF signaling pathway
NOS3; RAC2; MAPK14B; MAPKAPK2; BADB; PIK3R3; PPP3R1; MAPK13; HRASA; MAP2K1
Osteoclast differentiation
MITF; TREM2; IFNGR1; CSF1R; TGFB1; PPP3CB; STAT2; OSCAR; CSF1; SIRPB1
Natural killer cell mediated cytotoxicity
IFNA4; PRKCG; RAET1E; ZAP70; VAV2; PIK3CG; IFNA2; IFNGR1; PLCG1; Ifna11
T cell receptor signaling pathway
MAP2K7; CABIN1; TEC; VAV3; GRB2; RAF1; VAV2; HRAS; NFATC3; IKBKB
B cell receptor signaling pathway
AKT2; PPP3CB; LIME1; AKT1; ARPC2; IGHM; MAPK1; DUSP4; MAPK4; ITPR2
Long-term potentiation
RPS6KA3; CAMK2B; ITPR1; MAP2K1; GRIN2C; PRKCA; CALM3; CALML3; ITPR3; CAMK4
Glutamatergic synapse
GRM4; GNG3; PLCB3; GNAI2; PPP3CB; GRIN2D; GRIN2B; GNG10; GRIN2A; DLGAP1
Dopaminergic synapse
ATF4; GRIA4; DRD4; PRKCB; TH; KCNJ5; MAPK9; PRKACB; GNG11; PPP2R1A
Oxytocin signaling pathway
EEF2K; CACNA2D2; PPP3R2; NFATC1; CD38; PRKAG1; PLA2G4F; MYL6B; OXT; MYLK3
Glucagon signaling pathway
PCK2; ITPR3; ATF4; SLC2A2; PYGB; SIK2; GNAQ; PCK1; SMEK1; PRKAG1
Renin secretion
PLCB2; GUCY1B3; CLCA5; PDE3A; PPP3CB; CLCA1; CALM2; PLCB3; REN2; GNAS
Alzheimers disease
APAF1; NDUFA1; TNFRSF1A; AKR1C1; COX4I2; PLCB4; PLCB1; BACE2; TNF; COX7A2
Amyotrophic lateral sclerosis (ALS)
MAP2K3; PRPH; CASP1; CASP9; DAXX; GPX1; NOS1; RAC1; GRIA2; ALS2
Amphetamine addiction
GRIA4; SLC18A2; ATF6B; SLC6A3; PRKCG; PRKCA; CREB3L4; FOS; GNAS; GRIN2A
Tuberculosis
SPHK2; Ifna11; PPP3CB; MAPK8; FCGR2A; IFNA5; BID; FCGR3A; ATP6V0C; HLA-DQA2
HTLV-I infection
HLA-A; MYBL1; NFKB1; CRTC2; NFATC1; NRP1; PDGFB; MAPK8; FZD8; EGR1

Protein Function

PPP3CB has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CB itself. We selected most functions PPP3CB had, and list some proteins which have the same functions with PPP3CB. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDH2G7; CCDC167; KCNIP1; CALUB; PCDH2AA15; CDH10A; GUCA1E; ANXA2A; VCAN; MELK
Function calcium-dependent protein serine/threonine phosphatase activity
Related Protein CAMK2G; PPP3R1; NETO2; PPP3CB
Function calmodulin binding
Related Protein EPB41; CAMK2A; MYO5C; MYO9B; CAMSAP1; KCNN1A; MARCKSL1A; ARPP21; CAMK1G; ENKUR
Function calmodulin-dependent protein phosphatase activity
Related Protein PPP3CB; PPM1A; PPM1F; PPP3CA
Function drug binding
Related Protein PDE4C; GABRA1; DRD2; CNR1; SETD6; SLC6A4A; SRP54; PIGC; TYMS; DRD4
Function enzyme binding
Related Protein SLC27A2; PPP1R3D; DNM2; PTPN1; PPP3CA; NOP14; GSTM3; BCL10; TAF10; PARP1
Function hydrolase activity
Related Protein RHOT1B; FAM105B; ENPP2; TMPRSS13A; F2RL1.2; NUDT17; PRSS40; ATP1A3A; DDX39AA; PTPN2B
Function metal ion binding
Related Protein ADI1; PPP4CB; HIVEP2A; STEAP3; ZNF143A; THAP7; GALNT14; FBXO30B; BCL11B; OSR2
Function phosphoprotein phosphatase activity
Related Protein PPM1AA; PTEN; PPP4CA; PTPRDB; PHPT1; DUSP26; PPM1DB; PPEF2; PPM1LB; PPP1CAA
Function protein binding
Related Protein TRIM32; HAPLN2; GK; F2R; PRKAR2AA; DMBT1; CCL11; NDUFAF4; HSPB11; LRRC29
Function protein dimerization activity
Related Protein FAP; ZBED1; ID4; BETA3; MYO5A; HER2; TCF3A; HELT; MITFB; MYCLB
Function protein heterodimerization activity
Related Protein HIST1H2AF; MAPK6; SYT5; ADRB1; BCL2A; LTC4S; VEGFA; SNX6; BRAF; SMC3
Function protein phosphatase 2B binding
Related Protein MYOZ2; SLC9A1; SOD1; AKAP5; BAD; PPP3CB; AKAP1; ATP2B4
Function protein serine/threonine phosphatase activity
Related Protein EPM2A; PPM1N; PHLPP2; PPP5C; PPM1E; PPP4C; CDC14A; LCK; CDC14C; ILKAP

Interacting Protein

PPP3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CB.
Akap5; NFATC1; Akap6; Ppp3r1; Hmga2; Ywhae; Dlg4; Map3k5

PPP3CB Related Articles

Vasu, S; McClenaghan, NH; et al. Cellular responses of novel human pancreatic beta-cell line, 1.1B4 to hyperglycemia. ISLETS 5:170-177(2013).
Polovkova, OG; Makeeva, OA; et al. Expression Profiles of Calcineurin Pathway Genes in Myocardium in Relation to Ischemic Heart Remodeling in Humans. MOLECULAR BIOLOGY 47:382-388(2013).