RAD9A
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Official Full Name
RAD9 homolog A
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Overview
Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene. This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. -
Synonyms
RAD9A; RAD9 homolog A (S. pombe); RAD9, RAD9 (S. pombe) homolog; cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A; RAD9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RAD9A-2385H | Recombinant Human RAD9 Homolog A (S. Pombe) | Insect Cell | N/A |
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| Human | RAD9A-2551HCL | Recombinant Human RAD9A 293 Cell Lysate | HEK293 | N/A |
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| Mouse | Rad9a-5353M | Recombinant Mouse Rad9a Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Cynomolgus Monkey | RAD9A-840C | Recombinant Cynomolgus RAD9A Protein, His-tagged | Mammalian Cell | His |
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| Cynomolgus Monkey | RAD9A-583C-B | Recombinant Cynomolgus Monkey RAD9A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Cynomolgus Monkey | RAD9A-583C | Recombinant Cynomolgus Monkey RAD9A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Chicken | RAD9A-7136C | Recombinant Chicken RAD9A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
RAD9A involved in several pathways and played different roles in them. We selected most pathways RAD9A participated on our site, such as Activation of ATR in response to replication stress, Androgen receptor signaling pathway, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD9A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of ATR in response to replication stress | HUS1;MCM10;RAD1;RAD9A;RAD9;RAD17;CHEK1;RAD9B;CDK2 |
| Androgen receptor signaling pathway | CREBBP;RAD9A;NR0B2A;KAT7B;HTATIP;RNF6;RNF4;DAXX;DSTN |
| Cell Cycle | ARPP19B;YWHABL;CDCA5;FAM175A;BLZF1;YWHAE;MCM4;SYCP2;MYCA |
| Cell Cycle Checkpoints | BARD1;RAD9;FAM175A;RAD9A;YWHAQ;BRCC3;UBE2V2;CDK5RAP2;MCM8 |
| DNA Double-Strand Break Repair | EME2;PAXIP1;RAD9;RNF4;EYA2;TDP2B;EYA3;BRCC3;UBE2V2 |
| DNA Repair | USP43A;PPP4CA;SPRTN;KIAA0101;DNA2;RNF4;RAD17;RNF168;CETN2 |
| DNA damage response | RAD1;RAD9A;GADD45A;RAD17;HUS1B;CDK5;CHEK2;DDB2;TLK2 |
| G2/M Checkpoints | RAD1;RNF168;RAD9B;UIMC1;RAD9A;RAD17;BRCC3;BABAM1;RAD9 |
RAD9A has several biochemical functions, for example, 3-5 exonuclease activity, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD9A itself. We selected most functions RAD9A had, and list some proteins which have the same functions with RAD9A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 exonuclease activity | RAD9;WRN;EXOSC10;POLE;EXD2;EXD1;MRE11A;RAD9B;REV3L |
| SH3 domain binding | CD3E;CRB3;DENND1A;ITGB1BP2;SH3BP5;FMN1;WAS;PTPN12;SKAP1 |
| enzyme binding | Ar;PPP3CA;PAWR;POLB;GBP1;SLC27A2;NFKBIA;ATG3;BCHE |
| exodeoxyribonuclease III activity | RAD9A;RAD9;TREX2;TREX1;RAD1 |
| histone deacetylase binding | KPNA2;NCOR2;MAGEA2;CEBPA;SP2;TAL1;CEBPB;MEF2B;HDAC9 |
| protein binding | TNFAIP8;CEP170L;QARS;PPFIA1;AFG3L2;ATP6AP2;NACA;ZFAND6;GDPD5 |
| protein kinase binding | CASP9;STX1B;SNAP91;PEBP1;PTPN23;GOLGA2;IL31RA;PLK1;GRIN2A |
RAD9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD9A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD9A.
HUS1; RAD1; RAD17; TOPBP1; CLSPN; RAD17; SF3B3
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