rad9a
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  • Official Full Name
  • RAD9 homolog A
  • Background
  • Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene. This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.
  • Synonyms
  • RAD9A; RAD9 homolog A (S. pombe); RAD9, RAD9 (S. pombe) homolog; cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A; RAD9
Cat.#:RAD9A-2385HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAD9 Homolog A (S. Pombe)
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Cat.#:RAD9A-840CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RAD9A Protein, His-tagged
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Cat.#:RAD9A-7136CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAD9A
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Cat.#:RAD9A-2551HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAD9A 293 Cell Lysate
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Involved Pathway

RAD9A involved in several pathways and played different roles in them. We selected most pathways RAD9A participated on our site, such as Activation of ATR in response to replication stress, Androgen receptor signaling pathway, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD9A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of ATR in response to replication stress
HUS1; RAD1; RAD9A; CLSPN; RAD9; RAD9B; DBF4; MCM10; MCM8; CDK2
Androgen receptor signaling pathway
AES; EGFR; ETV5A; GNB2L1; PNRC1; JUN; NCOA2; SMAD3B; CREBBP; TGFB1I1
Cell Cycle
NIPBL; SMC4; TUBG1; CCNA1; MCM3; H3F3D; CDC14AA; CCNB3; BRCC3; GOLGA2
Cell Cycle Checkpoints
BRCC3; RAD50; RAD17; UBE2V2; CHEK2; DBF4; RAD1; CDKN1B; MCM8; BRE
DNA Double-Strand Break Repair
UBE2V2; EYA2; RIF1; TIMELESS; RAD9B; CHEK2; FAM175A; RAD9A; PPP4R2; KDM4A
DNA Repair
FAM175A; YY1; CLSPN; DDB2; DDB1; KDM4B; INO80E; TIPIN; HUS1; COPS4
DNA damage response
GADD45A; TLK2; CHEK2; DDB2; RAD17; CDK5; RAD9A; GADD45G; HUS1B; RAD1
G2/M Checkpoints
RAD9; TP53BP1; BARD1; RNF168; RAD9A; BRE; HUS1; BRCC3; RAD9B; UIMC1

Protein Function

RAD9A has several biochemical functions, for example, 3-5 exonuclease activity, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD9A itself. We selected most functions RAD9A had, and list some proteins which have the same functions with RAD9A. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein POLE; POLA1; POLG; WRN; EXD2; RAD9; REXO2; ERI1; RAD1; TREX1
Function SH3 domain binding
Related Protein PLSCR1; VASPA; EFS; ADAM10; CTTNBP2; MICAL1; PTPN22; SIRPA; MYPN; FMN1
Function enzyme binding
Related Protein MAT2B; HIST1H2AG; C2orf56; NOXA1; ATP2A2; KMT2E; RFC5; HMGA1; DVL1; PARP1
Function exodeoxyribonuclease III activity
Related Protein RAD9; TREX1; RAD9A; TREX2; RAD1
Function histone deacetylase binding
Related Protein NRIP1; ANKRA2; HOXA10; BRMS1; RUNX2; NUDT21; HIC1; HDAC1; RAD9; NKX2-5
Function protein binding
Related Protein GPA33; RRAGD; PAK6; CALCR; CASK; TRAP1; RIT1; KCNQ4; UBE2W; PDZD11
Function protein kinase binding
Related Protein NBEA; CCNT2A; ADAM10; TRAF3; PAX6; CACNB3; RB1CC1; ATG13; MAP2K6; NEK6

Interacting Protein

RAD9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD9A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD9A.
HUS1; RAD1; RAD17; TOPBP1; CLSPN; RAD17; SF3B3