RAD9A

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RAD9A

Official Full Name RAD9 homolog A
Background Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the RAD9A gene. This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene.
Synonyms RAD9A; RAD9 homolog A (S. pombe); RAD9, RAD9 (S. pombe) homolog; cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A; RAD9
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RAD9A-2385H Recombinant Human RAD9 Homolog A (S. Pombe) Insect Cell N/A
    Human RAD9A-2551HCL Recombinant Human RAD9A 293 Cell Lysate HEK293 N/A
    Cynomolgus Monkey RAD9A-840C Recombinant Cynomolgus RAD9A Protein, His-tagged Mammalian Cell His
    Chicken RAD9A-7136C Recombinant Chicken RAD9A Mammalian Cell His

    RAD9A involved in several pathways and played different roles in them. We selected most pathways RAD9A participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD9A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of ATR in response to replication stress MCM10; RAD9B; RAD9A; HUS1; MCM8; DBF4; RAD9; RAD1; CLSPN; RAD17
    Androgen receptor signaling pathway CARM1; EFCAB6; KAT5; KAT7B; PIAS3; KAT7; RANBP9; PARK7; DAXX; HTATIP
    Cell Cycle TERF1; CCNB1; CDC6; SFN; TGFB2; NPM1; UIMC1; NIPBL; CSNK1D; NUDC
    Cell Cycle Checkpoints MCM10; CHEK2; CDK2; RAD50; CLSPN; YWHAQ; BRE; RNF168; CDKN1B; RAD17
    DNA Double-Strand Break Repair RAD9A; PPP4R2B; POLD3; PARP1; FAM175A; UBE2V2; EME1; RAD50; TDP1; RHNO1
    DNA Repair COPS3; PPIE; RAD18; PPP4R2; PPP4R2A; COPS2; POLI; UBE2V2; KIAA1530; PAXIP1
    DNA damage response TLK2; GADD45G; CDK5; RAD9A; GADD45A; HUS1B; RAD1; RAD17; DDB2; CHEK2
    G2/M Checkpoints UIMC1; BABAM1; FAM175A; RAD9B; RAD1; HUS1; TP53BP1; RAD17; RNF168; RAD9

    RAD9A has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD9A itself. We selected most functions RAD9A had, and list some proteins which have the same functions with RAD9A. You can find most of the proteins on our site.

    Function Related Protein
    3-5 exonuclease activity EXD1; TREX1; RAD9; POLE; APLF; RAD1; APEX1; POLG; RAD9A; POLA1
    SH3 domain binding SHANK1; SIRPA; ARHGAP27; PAK3; SH3BP1; QKI; PLSCR4; PTPN12; BCAR1; MICAL1
    enzyme binding PAWR; RPA3; RPS3; CYB5A; BLZF1; GBP1; NR5A1; PARK2; SELS; EGLN1
    exodeoxyribonuclease III activity RAD9; TREX2; RAD1; RAD9A; TREX1
    histone deacetylase binding RELA; HDAC6; NR2C1; GMNN; CDC20; SP2; YY1; DHX36; TOP2B; SIRT2
    protein binding PTPN1; FGFR3; SMAD9; RIMS1; SAC3D1; VAV1; SAP30BP; TMEM174; ACTN2; CYGB
    protein kinase binding PRKAG3; PRKAG1; VRK2; CDK5RAP1; TPX2; CCNYL1; CACNB3; STXBP1; CAMK2N1A; CAMK2N2

    RAD9A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD9A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD9A.

    HUS1; RAD1; RAD17; TOPBP1; CLSPN; RAD17; SF3B3

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