RAG1 Protein, recombination activating gene 1

RAG1

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RAG1

Official Full Name recombination activating gene 1
Background The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some
Synonyms RAG1; recombination activating gene 1; V(D)J recombination-activating protein 1; MGC43321; recombination activating protein 1; RING finger protein 74; RNF74; V(D)J recombination activating protein 1; RAG-1
    • Species :
    • Chicken
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse RAG1-13889M Recombinant Mouse RAG1 Protein Mammalian Cell His
    Rhesus Macaque RAG1-3776R Recombinant Rhesus monkey RAG1 Protein, His-tagged Mammalian Cell His
    Chicken RAG1-2853C Recombinant Chicken RAG1 Mammalian Cell His
    Zebrafish RAG1-8963Z Recombinant Zebrafish RAG1 Mammalian Cell His

    RAG1 involved in several pathways and played different roles in them. We selected most pathways RAG1 participated on our site, such as FoxO signaling pathway, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway IL7R; HOMER1; MDM2; SGK3; MAPK11; HRASB; TGFBR1; FASLG; CAT; HRASA
    Primary i RAG2; IL2RG; ICOS; TNFRSF13B; Cd79a, Cd79b; CD8B; RFX5; RFXAP; BLNK; CD3D
    nodeficiency CD8B1; IL7R; ICOS; CD3E; ORAI1; CD8A; RAG1; RFX5; BTK; UNG

    RAG1 has several biochemical functions, for example, DNA binding, T/G mismatch-specific endonuclease activity, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG1 itself. We selected most functions RAG1 had, and list some proteins which have the same functions with RAG1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TSHZ3; ARX; TP53; IRF2A; CDX1B; TRP63; CHRAC1; ZNF705B; HOXB13A; RCOR2
    T/G mismatch-specific endonuclease activity SMG6; GDPD4; EXO5; MEIOB; ZRANB3; REXO4; RAG1; TMPPE; RNASEKA; ENDOU2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity MARCH6; HECW2; RNF169; MUL1A; NEURL3; MGRN1A; DTX1; UBE2IA; MYLIPB; UBR1
    acid-amino acid ligase activity RNF41; UBA3; RAG1; TRIM25
    catalytic activity PNP6; ACSM2; RTCD1; LYZ1; PPTC7A; GPT2L; PPM1BB; GAD1B; PLD1A; HSD3B6
    coenzyme F420-0 gamma-glutamyl ligase activity RFWD2; RNF169; UBR1; MARCH11; SHRPRBCK1R; ITCHA; SIAH2L; RNF187; DTX1; TRIM50
    coenzyme F420-2 alpha-glutamyl ligase activity RFWD2; TRIM50; SIAH2L; MARCH6; LTN1; UBR1; RC3H2; NEURL1B; MGRN1A; ZNRF3
    endonuclease activity CL2; RNASEL4; ZC3H12A; RNASEL3; ANG; SMG6; ENDOG; RSFR; EAR4; RNASEKA
    histone binding SERPINB1A; RNF20; ATRX; HIST1H3A; SUPT6H; HIST4H4; HIST1H4B; DEK; BRD7; CHAF1B
    hydrolase activity CASP3A; INPP5KA; USP27X; USPL1; DPYSL5A; EGFBP2; PSMC1B; ATP1A1A.5; ASAH1A; F2RL1.1
    hydrolase activity, acting on ester bonds C11orf54; PGAP3; PTER; RAG1; APMAP; ACY3.2; LIPM; LIPN; ENDOU2; ASPA
    ligase activity GLULB; IRF2BP1; BIRC7; RNF25; RC3H2; DTX3; TRAF6; TRIM5; FANCL; RBCK1
    metal ion binding ZFP410; TM9SF1; CAR1; SP5; ZRSR2; PCK2; ZNF131; ZNF584; XPNPEP2; MOB2
    nuclease activity DOM3Z; USB1; EAR5; SMG6; MEIOB; TMPPE; EXO5; RNASEKA; DNASE2A; RNASEKB
    nucleic acid binding RSFR; POLR2GL; TREX2; MSI2A; KLF2A; ZKSCAN17; RBPMS2; SRSF2A; ZFP11; RBM24B
    phosphoric ester hydrolase activity ZRANB3; MEIOB; EXO5; RNASEKB; SYNJ1; FBP1A; REXO4; SACM1LB; RAG1; GDPD4
    protein binding CREB1; CYP2S1; NRL; FLOT1; TTLL6; KLRC1; MYO7A; TRDN; UBTD1; HTR1E
    protein homodimerization activity PEX7; NRBP1; ATPIF1A; DGCR8; C9orf142; BMP2B; Bcl2a1b; DAXX; TRIM8; TCF12
    protein-glutamic acid ligase activity ZNRF2B; MYLIPB; RAG1; MYLIPA; SIAH2L; TRIM50; ZNRF3; SHRPRBCK1R; HERC2; NEURL3
    protein-glycine ligase activity RNF187; MARCH11; RNF144AA; ZNRF3; UBE2IB; TMEM129; ARIH1L; SIAH2L; SIAH1A; MARCH4
    protein-glycine ligase activity, elongating SIAH1A; RNF144AB; UBR1; RNF169; RNF187; G2E3; MYLIPA; MGRN1A; MARCH11; TRIM41
    protein-glycine ligase activity, initiating ITCHA; NEURL1B; UBR1; G2E3; NEURL3; TRIM50; RNF144AB; HECW2; RFWD2; DTX1
    retroviral 3 processing activity SMG6; GDPD4; ENDOU2; RNASEKA; REXO4; MEIOB; ZRANB3; RAG1; RNASEKB; REXO1
    ribosomal S6-glutamic acid ligase activity RFWD2; HERC2; TRIM71; SIAH1A; ARIH1L; MYLIPA; UBE2M; TMEM129; RAG1; MARCH6
    sequence-specific DNA binding EDF1; HOXA4A; RHOXF1; PAX3A; TFAP2B; FOXD5; FOXQ1A; HOXB10A; GATAD2AB; FOXD1L
    tubulin-glutamic acid ligase activity RNF149; RNF180; HERC2; RC3H2; DTX1; ZNRF3; SIAH2L; RAG1; MARCH6; UBE2IA
    tubulin-glycine ligase activity MYLIPA; UBR1; ARIH1L; NEURL1B; SIAH2L; MARCH9; HECW2; MUL1A; DTX1; G2E3
    ubiquitin protein ligase activity UBR3; MSL2A; PELI1; TRIM11; MSL2; UBE2G1B; HERC3; UBE2W; MSL2B; UBE2J2
    ubiquitin-protein transferase activity UBE2K; UBE2Q2; MARCH5; RNF144AA; RNF146; SIAH1A; RNF130; RNF20; FBXL14B; DTX3L
    zinc ion binding CPA5; POLR2L; VPS11; BMP1B; ZDHHC18B; ZEB1; TRIM48; BTR09; NR4A2B; ZDHHC3B

    RAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG1.

    Rag2; VPRBP; KPNA1; Ywhae; CUL4A

    Aird, AL; Nevitt, CD; et al. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. EXPERIMENTAL GERONTOLOGY 63:18-26(2015).
    Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).

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