• Official Full Name
  • regulatory factor X, 5 (influences HLA class II expression)
  • Background
  • A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
  • Synonyms
  • RFX5; regulatory factor X, 5 (influences HLA class II expression); DNA-binding protein RFX5; DNA binding protein RFX 5; DNA binding protein RFX5; Influences HLA class II expression; Regulatory factor X 5; Regulatory factor X subunit 5; RFX 5; Rfx5 protein; OTTHUMP00000014465; OTTHUMP00000081737; OTTHUMP00000082795; OTTHUMP00000082796; OTTHUMP00000196318; OTTHUMP00000196321
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RFX5 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human RFX5 293 Cell Lysate

Involved Pathway

RFX5 involved in several pathways and played different roles in them. We selected most pathways RFX5 participated on our site, such as Antigen processing and presentation, Tuberculosis, Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFX5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
Primary i
IL7R; CD8B; CD40LG; CD3E; Cd79a, Cd79b; CD8A; ICOS; UNG; TAP1; RFX5
CD8A; ZAP70; IL7R; RAG2; TAP1; CD40; CD19; AICDA; CD3D; CD40LG

Protein Function

RFX5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFX5 itself. We selected most functions RFX5 had, and list some proteins which have the same functions with RFX5. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein NKRF; GPBP1; TAF11; LHX2A; ZNF180; POLR1E; NKX2.3; SMARCAD1; FAM170A; ZNF726
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NCOA2; CLOCK; NR1D1; PBX1; GATA4; SP1; SPI1; HINFP; SIX1; SMAD1
Function protein binding
Related Protein TMEM132D; RNF135; TLR4; RLTPR; CCNF; MRAP; GTF2A2; SEC61G; ELOVL6; NRBF2
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN1; FOXD3; HIST1H2AH; RORCB; ZNF131; STAT3; ALX3; ZFP146; ZNF182; VAX2

Interacting Protein

RFX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFX5.
HDAC2; lysA; collagen sequence; RFXAP; SIN3B; CDC73; GIGYF2; CDC5L

RFX5 Related Articles

Surmann, EM; Voigt, AY; et al. Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:357-366(2015).
Michel, S; Linnebacher, M; et al. Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes. INTERNATIONAL JOURNAL OF CANCER 127:889-898(2010).