• Official Full Name
  • ribosomal protein L10a
  • Background
  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
  • Synonyms
  • RPL10A; ribosomal protein L10a; NEDD6; 60S ribosomal protein L10a; Csa 19; L10A; NEDD-6; neural precursor cell expressed developmentally down-regulated protein 6; Csa-19
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPL10A, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPL10A Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPL10A Protein
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RPL10A Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RPL10A Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPL10A
Source (Host):Species:Human
Product nameRecombinant Human RPL10A 293 Cell Lysate

Involved Pathway

RPL10A involved in several pathways and played different roles in them. We selected most pathways RPL10A participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RPL34-PS1; RPL11; MRPL22; RPLP2L; MRPL28; RPL22L1; RPS20; MRPL18; RPL38; RPL10

Protein Function

RPL10A has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL10A itself. We selected most functions RPL10A had, and list some proteins which have the same functions with RPL10A. You can find most of the proteins on our site.
Related Protein
Function poly(A) RNA binding
Related Protein TFB1M; CCDC108; MRPL37; MTPAP; DIDO1; RPS12; MBNL3; PRRC2A; LRRC47; EIF4G3
Function protein binding
Related Protein PKN1; UBE2Z; RASSF9; HSD17B12; EAF1; RPS19; RPGRIP1; MARVELD2; BAHD1; MAPK4
Function structural constituent of ribosome
Related Protein MRPL32; MRPL1; MRPS25; MRPL15; RPLP1; RPL28; RPS16; MRPL36; MRPS15; MRPS30

Interacting Protein

RPL10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL10A here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL10A.
RGS17; VCAM1; LRRK2; YWHAZ; MAP3K1; MAP3K14; SRPR; ACTB; midostaurin; Srp72; NOP56; Smad6; GABARAP

RPL10A Related Articles

Grgic, I; Hofmeister, AF; et al. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. KIDNEY INTERNATIONAL 86:1116-1129(2014).
Drane, L; Ainsley, JA; et al. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. FRONTIERS IN MOLECULAR NEUROSCIENCE 7:-(2014).