• Official Full Name
  • SECIS binding protein 2
  • Background
  • The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.
  • Synonyms
  • SECISBP2; SECIS binding protein 2; selenocysteine insertion sequence-binding protein 2; DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SECISBP 2; Selenocysteine insertion sequence binding protein 2; OTTHUMP00000021618; OTTHUMP00000069896; SECIS-binding protein 2
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SECISBP2, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SECISBP2 Protein
Source (Host):Species:Human
Product nameRecombinant Human SECISBP2 293 Cell Lysate

Protein Function

SECISBP2 has several biochemical functions, for example, mRNA 3-UTR binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SECISBP2 itself. We selected most functions SECISBP2 had, and list some proteins which have the same functions with SECISBP2. You can find most of the proteins on our site.
Related Protein
Function mRNA 3-UTR binding
Related Protein TUT1; ELAVL2; KHSRP; RIMS2; AUH; CPEB1; RBM38; CPEB4; PPP1R2P9; RNPS1
Function poly(A) RNA binding
Related Protein CKAP4; TBL3; RPUSD4; SNRPD3; SUGP1; PRPF38B; CPSF6; SEC23IP; SAMD4B; RPS19
Function protein binding
Related Protein HER5; NPBWR1; TERF2; TBC1D7; GTF2H2; ARHGEF40; PRKACA; ACE2; PHB2; RAB3A
Function ribonucleoprotein complex binding
Function selenocysteine insertion sequence binding
Related Protein NCL; SECISBP2

Interacting Protein

SECISBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SECISBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SECISBP2.
GOLGA2; SMAD9; PA; ATXN7L3; q9wmx2-pro_0000037548

SECISBP2 Related Articles

Bubenik, JL; Miniard, AC; et al. Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2. RNA BIOLOGY 11:1402-1413(2014).
Seeher, S; Atassi, T; et al. Secisbp2 Is Essential for Embryonic Development and Enhances Selenoprotein Expression. ANTIOXIDANTS & REDOX SIGNALING 21:835-849(2014).