SEPT10

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SEPT10

Official Full Name septin 10
Background This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where its believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternate splicing results in two transcript variants encoding
Synonyms SEPT10; septin 10; septin-10; FLJ11619; sept1 like; SEPT 10; OTTHUMP00000207015; OTTHUMP00000207016; OTTHUMP00000207017; OTTHUMP00000207018; OTTHUMP00000207019
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEPT10-1072H Recombinant Human SEPT10 Mammalian Cell His
    Human SEPT10-1966HCL Recombinant Human SEPT10 293 Cell Lysate HEK293 N/A
    Human SEPT10-2581H Recombinant Human SEPT10, GST-tagged E.coli GST
    Rat SEPT10-5322R Recombinant Rat SEPT10 Protein Mammalian Cell His
    Zebrafish SEPT10-2337Z Recombinant Zebrafish SEPT10 Mammalian Cell His

    SEPT10 involved in several pathways and played different roles in them. We selected most pathways SEPT10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    SEPT10 has several biochemical functions, for example, GTP binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT10 itself. We selected most functions SEPT10 had, and list some proteins which have the same functions with SEPT10. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding SEPT4A; RASL10B; EEF2A.1; RALB; RAB7A; GNAT2; RAB43; RAP1A; TUBA3E; SRPRB
    protein binding CNTNAP2; VPREB1; OLA1; PDE6G; ITSN1; PSMB3; RAD51D; OLFM1; PTGDS; PPP2CB

    SEPT10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT10.

    SEPT7; SEPT5; LSM8; YTHDC1; q9wmx2-pro_0000037548; pi3p

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