• Official Full Name
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1
  • Background
  • This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henles loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
  • Synonyms
  • SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; BSC1; NKCC2; solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC12A1 protein, His & T7-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC12A1, His-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC12A1
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC12A1 Protein

Involved Pathway

SLC12A1 involved in several pathways and played different roles in them. We selected most pathways SLC12A1 participated on our site, such as Cation-coupled Chloride cotransporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cation-coupled Chloride cotransporters
SLC12A3; SLC12A7; SLC12A1; SLC12A4; SLC12A5B
SLC-mediated transmembrane transport
SLC1A2A; SLC22A6; SLC13A3; SLC17A1; RHCGA; SLC2A13; SLC17A7A; SLC9A3.1; SLC26A3.1; SLC29A2
Transmembrane transport of small molecules
Transport of inorganic cations/anions and amino acids/oligopeptides
SLC17A1; SLC43A2B; SLC5A8; SLC17A7A; SLC4A1A; SLC26A3.2; SLC36A2; SLC9A3.1; SLC7A6; SLC4A4A

Protein Function

SLC12A1 has several biochemical functions, for example, potassium ion symporter activity, potassium:chloride symporter activity, sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A1 itself. We selected most functions SLC12A1 had, and list some proteins which have the same functions with SLC12A1. You can find most of the proteins on our site.
Related Protein
Function potassium ion symporter activity
Related Protein SLC12A7; SLC12A2; SLC12A4; SLC12A10.1; SLC12A10.2; SLC12A10.3; SLC12A8; SLC12A5; SLC12A5B; SLC12A1
Function potassium:chloride symporter activity
Related Protein SLC12A7; SLC12A5B; SLC12A8; SLC12A1; SLC12A10.3; SLC12A10.1; SLC12A5; SLC12A4; SLC12A2; SLC12A10.2
Function sodium ion transmembrane transporter activity
Related Protein TRAPPC10; ASIC4; CNNM4; SLC12A10.3; SLC12A10.2; SLC12A1; SLC12A10.1; SLC23A1; SLC12A3
Function sodium:chloride symporter activity
Related Protein SLC12A10.2; SLC12A3; SLC12A1; SLC12A10.1; SLC12A10.3
Function sodium:potassium:chloride symporter activity
Related Protein SLC12A10.1; SLC12A10.3; SLC12A1; SLC12A10.2

Interacting Protein

SLC12A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A1.
pta; Oxsr1; Stk39

SLC12A1 Related Articles

Rasmussen, LJH; Muller, HSH; et al. Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C101-C110(2015).
Castrop, H; Schiessl, IM; et al. Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 307:F991-F1002(2014).