SLC12A1

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SLC12A1

Official Full Name solute carrier family 12 (sodium/potassium/chloride transporter), member 1
Background This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henles loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
Synonyms SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; BSC1; NKCC2; solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SLC12A1-1202H Recombinant Human SLC12A1 protein, His & T7-tagged E.coli His/T7
    Human SLC12A1-2697H Recombinant Human SLC12A1, His-tagged E.coli His
    Human SLC12A1-31410TH Recombinant Human SLC12A1 Wheat Germ N/A
    Mouse SLC12A1-15207M Recombinant Mouse SLC12A1 Protein Mammalian Cell His

    SLC12A1 involved in several pathways and played different roles in them. We selected most pathways SLC12A1 participated on our site, such as Cation-coupled Chloride cotransporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cation-coupled Chloride cotransporters SLC12A3; SLC12A7; SLC12A1; SLC12A5B; SLC12A4
    SLC-mediated transmembrane transport SLC30A5; SLC15A2; SLC3A2B; SLC38A3A; SLC20A1A; SLC24A5; SLC20A1; MATE4; SLC13A1; SLC17A7A
    Transmembrane transport of small molecules SLC12A1; SLC9A10; SLC12A3; SLC4A2A; RHBG; TRPC4B; ABCB8; AQP3A; ANO4; SLC28A3
    Transport of inorganic cations/anions and amino acids/oligopeptides SLC34A2A; SLC34A3; SLC9A8; SLC6A6; SLC4A1B; SLC5A8; SLC17A7A; SLC4A8; SLC26A3.1; SLC9A6A

    SLC12A1 has several biochemical functions, for example, potassium ion symporter activity, potassium:chloride symporter activity, sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A1 itself. We selected most functions SLC12A1 had, and list some proteins which have the same functions with SLC12A1. You can find most of the proteins on our site.

    Function Related Protein
    potassium ion symporter activity SLC12A5B; SLC12A7; SLC12A5; SLC12A10.2; SLC12A10.3; SLC12A2; SLC12A1; SLC12A10.1; SLC12A4; SLC12A8
    potassium:chloride symporter activity SLC12A10.1; SLC12A10.2; SLC12A5B; SLC12A8; SLC12A4; SLC12A5; SLC12A1; SLC12A10.3; SLC12A2; SLC12A7
    sodium ion transmembrane transporter activity ASIC4; SLC23A1; SLC12A1; SLC12A10.2; CNNM4; SLC12A10.1; TRAPPC10; SLC12A3; SLC12A10.3
    sodium:chloride symporter activity SLC12A10.3; SLC12A10.2; SLC12A1; SLC12A10.1; SLC12A3
    sodium:potassium:chloride symporter activity SLC12A1; SLC12A10.3; SLC12A10.1; SLC12A10.2

    SLC12A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A1.

    pta; Oxsr1; Stk39

    Rasmussen, LJH; Muller, HSH; et al. Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C101-C110(2015).
    Castrop, H; Schiessl, IM; et al. Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 307:F991-F1002(2014).

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