slc7a8
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  • Official Full Name
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8
  • Background
  • Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
  • Synonyms
  • SLC7A8; solute carrier family 7 (amino acid transporter light chain, L system), member 8; LAT2; LPI-PC1; large neutral amino acids transporter small subunit 2; integral membrane protein E16H; L-type amino acid transporter 2; solute carrier family 7 (amino acid transporter, L-type), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8;
Cat.#:SLC7A8-15523MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC7A8 Protein
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Cat.#:SLC7A8-5579RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC7A8 Protein
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Cat.#:SLC7A8-4314RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SLC7A8 Protein, His-tagged
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Involved Pathway

SLC7A8 involved in several pathways and played different roles in them. We selected most pathways SLC7A8 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC7A8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein digestion and absorption
PRCP; PRSS1; ATP1A1; SLC36A1; COL10A1; SLC7A8; SLC3A1; COL6A6; PGA5; XPNPEP2

Protein Function

SLC7A8 has several biochemical functions, for example, L-amino acid transmembrane transporter activity, amine transmembrane transporter activity, amino acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC7A8 itself. We selected most functions SLC7A8 had, and list some proteins which have the same functions with SLC7A8. You can find most of the proteins on our site.
Function
Related Protein
Function L-amino acid transmembrane transporter activity
Related Protein SLC7A13; Nat3; SLC43A2B; SLC43A1A; SLC7A6; SLC7A14; SLC7A7; SLC7A8; SLC43A1B; SLC38A7
Function amine transmembrane transporter activity
Related Protein SLC22A16; SLC7A8; AQP9
Function amino acid transmembrane transporter activity
Related Protein SLC38A9; SLC3A1; SLC7A8; SLC7A3A; SLC38A10; SLC6A16B; SLC38A6; SLC38A11; SLC38A4; PEX3
Function antiporter activity
Related Protein SLC35E2; SLC26A3.1; SLC7A8; TMCO3; SLC9A3.2; CLCN4-2; CLCN6; SLC35D2; SLC35E3; SLC35E4
Function neutral amino acid transmembrane transporter activity
Related Protein SLC7A8; SLC6A19A; SLC43A1A; SLC43A1B; SLC7A10; SLC43A2B; SLC38A5; SLC43A2A; SLC6A19B; SLC3A2
Function organic cation transmembrane transporter activity
Related Protein SLC22A14; SLC22A1; SLC22A2; SLC22A3; SLC7A8
Function toxin transporter activity
Related Protein SLC22A3; SLC7A8; LRP6; SLC22A2; SLC17A3; ABCG1