• Official Full Name
  • SMG6 nonsense mediated mRNA decay factor
  • Background
  • This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
  • Synonyms
  • SMG6; SMG6 nonsense mediated mRNA decay factor; EST1A; SMG-6; C17orf31; hSMG5/7a; telomerase-binding protein EST1A; telomerase subunit EST1A; ever shorter telomeres 1A; EST1 telomerase component homolog A; smg-6 homolog, nonsense mediated mRNA decay factor;
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMG6 Protein

SMG6 Related Articles

Schmidt, SA; Foley, PL; et al. Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. NUCLEIC ACIDS RESEARCH 43:309-323(2015).
Wilusz, JE; Wilusz, J; et al. Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production. GENES & DEVELOPMENT 28:2447-2449(2014).