smg6
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  • Official Full Name
  • SMG6 nonsense mediated mRNA decay factor
  • Background
  • This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
  • Synonyms
  • SMG6; SMG6 nonsense mediated mRNA decay factor; EST1A; SMG-6; C17orf31; hSMG5/7a; telomerase-binding protein EST1A; telomerase subunit EST1A; ever shorter telomeres 1A; EST1 telomerase component homolog A; smg-6 homolog, nonsense mediated mRNA decay factor;
Cat.#:SMG6-15624MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMG6 Protein
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Involved Pathway

SMG6 involved in several pathways and played different roles in them. We selected most pathways SMG6 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
PELO; SMG7; PPP2CB; PPP2R1B; WDR82; PNN; PABPC1L2A; UPF1; MSI2A; RNMT

Protein Function

SMG6 has several biochemical functions, for example, DNA binding, T/G mismatch-specific endonuclease activity, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG6 itself. We selected most functions SMG6 had, and list some proteins which have the same functions with SMG6. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXN4; ZNF524; H2AFV; ZFAND5B; HOXB6B; PHTF1; ORC6L; ATXN1L; DHX9; POLR2C
Function T/G mismatch-specific endonuclease activity
Related Protein TMPPE; ZRANB3; MEIOB; RAG1; REXO1; RNASEKB; REXO4; SMG6; ENDOU2; EXO5
Function endonuclease activity
Related Protein ANG; RNASE6; EME2; PELO; DCLRE1C; EAR5; RAG1; PPP1R8; ERN2; RNASEL3
Function endoribonuclease activity
Related Protein TSNAX; CPSF3; PLD6; DROSHA; RNASEKA; DICER1; ERN1; RCL1; AGO2; NOB1
Function hydrolase activity
Related Protein BMP1B; ENOPH1; DUB1; NUDT6; IHHA; KLK1B26; PRSS40; NUDT8; ABHD17B; HTRA1B
Function metal ion binding
Related Protein ZNF177; PHF23A; ATX1; STAMBPL1; NR5A5; ZDHHC1; MUL1B; HMOX2; HBB-BH1; ZNF705A
Function nuclease activity
Related Protein CNOT6L; RNASEL4; TDP2B; EXO5; ZRANB3; ANG4; RNASEL3; ENDOG; EAR1; DNASE1L3L
Function phosphoric ester hydrolase activity
Related Protein RAG1; SACM1LA; GDPD4; FBP1A; SACM1LB; SMG6; REXO1; SACM1L; FBP1B; ZRANB3
Function retroviral 3 processing activity
Related Protein SMG6; ENDOU2; GDPD4; REXO1; RNASEKB; ZRANB3; MEIOB; REXO4; RNASEKA; TMPPE
Function telomeric DNA binding
Related Protein PIF1; XRCC5; POT1A; TERF1; TINF2; TERFA; CDAN1; NCL; SMG6; TP53BP1

SMG6 Related Articles

Schmidt, SA; Foley, PL; et al. Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. NUCLEIC ACIDS RESEARCH 43:309-323(2015).
Wilusz, JE; Wilusz, J; et al. Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production. GENES & DEVELOPMENT 28:2447-2449(2014).