• Official Full Name
  • SRY (sex determining region Y)-box 3
  • Background
  • This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
  • Synonyms
  • SOX3; SRY (sex determining region Y)-box 3; panhypopituitarism , PHP; transcription factor SOX-3; PHP; GHDX; MRGH; PHPX; SOXB
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOX3 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOX3
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOX3

Protein Function

SOX3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX3 itself. We selected most functions SOX3 had, and list some proteins which have the same functions with SOX3. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein PHTF1; ZFP287; PALB2; RFX5; SMC1B; HMGB3A; SRFB; ZNF672; ZBTB22; TIGD5
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein GBX2; WBP2; MTF1; H3F3B; TP53; NLRC5; IRF7; H2AFY; ZNF277; SOX8
Function RNA polymerase II transcription corepressor activity
Related Protein SOX3; TBX15; CTBP1; SIN3B; SIN3A; TCERG1; TLE1; HDAC1; BEND6; N4BP2L2
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD3A; NKX2-8; LCOR; NFE2L2B; THRA; MYCB; BHLHE22; MAFBA; POU3F2; ZNF396

SOX3 Related Articles

Rogers, N; Cheah, PS; et al. Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. GENE EXPRESSION PATTERNS 13:240-248(2013).
Hosoya, A; Kwak, S; et al. Immunohistochemical Localization of Cytokeratins in the Junctional Region of Ectoderm and Endoderm. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY 293:1864-1872(2010).