• Official Full Name
  • T-box 1
  • Background
  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TBX1; T-box 1; DGS; TGA; VCF; CAFS; CTHM; DGCR; DORV; VCFS; TBX1C; CATCH22; T-box transcription factor TBX1; brachyury; Testis-specific T-box protein; T-box 1 transcription factor C;
Source (Host):HEK293Species:Human
Product nameRecombinant Human TBX1 Protein, MYC/DDK-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TBX1

Protein Function

TBX1 has several biochemical functions, for example, DNA binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX1 itself. We selected most functions TBX1 had, and list some proteins which have the same functions with TBX1. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein PHOX2BA; PHC2; TIGD4; ZNF606; SCML4; SIX4; HES4; TEAD2; ZNF19; HIST1H4F
Function protein binding
Related Protein FAN1; FUBP3; DHX16; NINJ1; LRIF1; PELO; CENPP; ABI2; CCDC68; FBXL14
Function protein homodimerization activity
Function sequence-specific DNA binding
Related Protein TRP63; CREBZF; HOXA10B; HLX1; PAX2A; HNF4G; SP1; RXRAA; POU5F3; ENG2B
Function transcription factor activity, sequence-specific DNA binding
Related Protein AHR; TCF3A; SOX5; BATF3; HIC1; ZNF583; TBX19; ZFP82; INSM1A; ZNF79

TBX1 Related Articles

Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).
Kimura, W; Sharkar, MTK; et al. Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. TRANSGENIC RESEARCH 22:659-666(2013).