TCF7L2 Protein, transcription factor 7-like 2 (T-cell specific, HMG-box)


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Official Full Name transcription factor 7-like 2 (T-cell specific, HMG-box)
Background This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Synonyms TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); TCF4; transcription factor 7-like 2; TCF 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell facto
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TCF7L2-2068H Recombinant Human TCF7L2 Protein (1-456 aa), His-tagged E.coli His
    Human TCF7L2-1177HCL Recombinant Human TCF7L2 293 Cell Lysate HEK293 N/A
    Chicken TCF7L2-4511C Recombinant Chicken TCF7L2 Mammalian Cell His
    Zebrafish TCF7L2-8855Z Recombinant Zebrafish TCF7L2 Mammalian Cell His

    TCF7L2 involved in several pathways and played different roles in them. We selected most pathways TCF7L2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway MYCB; MAPK10; NKD1; WNT5A; DKK1; RHOAB; PORCN; PPP3CB; BAMBIA; PRKCBB
    Hippo signaling pathway SMAD3; GDF7; WNT10B; FRMD6; APC2; RASSF1; WNT16; TEAD4; APC; PPP2R2C
    Adherens junction RHOAC; BAIAP2; MET; SSX2IPA; VCL; PVRL1B; ACTN4; RAC2; PTPRB; TCF7L2
    Pathways in cancer FGF11; NKX3-1; HGF; FZD5; MAPK3; PTCH2; IL6; GLI3; PLCB3; RB1
    Colorectal cancer APC2; TP53; TGFB1; MSH3; RAC2; LEF1; ARAF; MAPK3; BCL2; APPL1
    Endometrial cancer TP53; MAPK3; ILK; NRAS; MLH1; PIK3CD; PIK3R1; BAD; PIK3R5; GSK3B
    Prostate cancer GRB2; PDGFRB; NFKB1; NKX3; PDGFD; RELA; PIK3R1; KRAS; IKBKB; Ar
    Thyroid cancer TCF7L2; RXRB; TP53; NTRK1; CCND1; MAP2K1; RET; HRAS; RXRG; BRAF
    Basal cell carcinoma FZD3; WNT4; STK36; Shh; FZD7; WNT11; TCF7; WNT9B; DVL2; SMO
    Acute myeloid leukemia SPI1; PIK3CD; IKBKB; JUP; PPARD; KIT; ARAF; CCND1; NFKB1; RARA
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA2; CACNB2; TCF7L2; LEF1; GJA1; CACNB1; CTNNA2; CACNB4; ITGA10; ITGA8

    TCF7L2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7L2 itself. We selected most functions TCF7L2 had, and list some proteins which have the same functions with TCF7L2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding TFE3B; FOSB; TCF3B; SFPI1; MYPOP; HLTF; ZIC1; ZKSCAN3; AKNA; GCM1
    RNA polymerase II core promoter sequence-specific DNA binding PAX6; YAP1; STAT5A; SUZ12; GATA6; H3F3B; TFAP2A; H2AFZ; TCF7L2; MTF1
    RNA polymerase II repressing transcription factor binding GTF2A2; TBX5A; MTA1; MKKS; TCF7L2; HDAC2; HDAC1; DMAP1; SIN3A; TBP
    armadillo repeat domain binding CHD8; AXIN2; STRN4; STRN; CALCOCO1; LEF1; CNOT1; CTNNBIP1; TCF7L2; AXIN1
    beta-catenin binding AXIN1; PXN; TRPC4; HDAC6; CARM1; EP300; PTBP3; KLF4; DACT3; SLC9A3R2
    chromatin binding SOX9; APITD1; SOX10; SIN3B; RELA; POU5F3; DMRT1; MSL1A; CNBPA; CTBP2
    gamma-catenin binding TCF7L2; APC2; DSG1A; Fert2; FER; CDH1; PTPRJ; CTNNA1; CDH2; APC
    nuclear hormone receptor binding Ankar; MYOD1; MED1; NCOA3; ACTN4; SNW1; TACC2; SMARCD3; CRX; NCOA2
    protein binding DPPA4; NDUFB9; POC5; AP1M1; GRIN2B; USP6; RSPO1; WBP1; AASDHPPT; YBX1
    protein kinase binding RFFL; GHR; PGAM1; ELAVL1; HDAC7; MAVS; C10orf46; AP2A2; IL12RB2; Cd24a
    sequence-specific DNA binding PRRXL1; SREBF1; TCF7L2; ZNF394; NR6A1B; FOXK2; PRRX1; TEFA; ZNF35; NR2F6B
    transcription factor activity, sequence-specific DNA binding MAFA; IKZF3; RUNX2; POU4F2; MTA1; TA; ZNF445; HLFB; SIX4; FOXS1
    transcription factor binding HMGA1; PIAS2; DIP2C; SIRT2; NFKBIA; NLRP3; CREBBP; LEF1; SUMO1; PELP1
    transcription regulatory region DNA binding ZNF174; TAF7L; KLF4; GLI1; KLF17; GATA6; ERBB4; GABPB1; HNF1A; ZFP639

    TCF7L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7L2.


    Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
    Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).

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