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TCF7L2

  • Official Full Name

    transcription factor 7-like 2 (T-cell specific, HMG-box)

  • Overview

    This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
  • Synonyms

    TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); TCF4; transcription factor 7-like 2; TCF 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell facto;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TCF7L2-1177HCL Recombinant Human TCF7L2 293 Cell Lysate HEK293 N/A
Human TCF7L2-3308H Recombinant Human TCF7L2 protein, His-tagged E.coli His 1-355 aa
Human TCF7L2-2068H Recombinant Human TCF7L2 Protein (1-456 aa), His-tagged E.coli His 1-456 aa
Zebrafish TCF7L2-8855Z Recombinant Zebrafish TCF7L2 Mammalian Cell His
Chicken TCF7L2-4511C Recombinant Chicken TCF7L2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TCF7L2 Related Articles

TCF7L2 involved in several pathways and played different roles in them. We selected most pathways TCF7L2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayWNT5B;NFATC2;GSK3B;WNT3A;CAMK2B1;PLCB1;RAC3B;RHOAA;MAP3K7
Hippo signaling pathwayLIMD1;FZD3;ITGB2;AREG;DLG3;SMAD7;ID2;TEAD2;WWTR1
Adherens junctionAASS;PVRL3;WASF1;FYNB;INSR;LMO7A;ACTN4;CDC42L;ACTN2
MelanogenesisMC1R;TYRP1B;GSK3AA;CAMK2D;TYR;WNT7A;WNT10B;WNT4;TCF7L1A
Pathways in cancerFGF10;BIRC7;MMP1;PLCB4;LAMC2;LAMA3;RASSF5;MAPK1;GNB2
Colorectal cancerPIK3CA;MAPK8;MSH6;RAC3;RALGDS;AKT1;TGFBR2;TP53;KRAS
Endometrial cancerPIK3CD;GSK3B;ARAF;PIK3R3;TCF7L2;TP53;CASP9;PIK3CG;AXIN2
Prostate cancerNKX3-1;CREB3L2;TP53;KRAS;ACTL6B;BCL2;FGFR2;CASP9;PIK3R2
Thyroid cancerRXRB;TRP53;NCOA4;RET;RXRA;TCF7;NTRK1;BRAF;KRAS
Basal cell carcinomaWNT9A;PTCH1;Fzd4;DVL2;FZD3;WNT16;APC2;BMP4;FZD7
Acute myeloid leukemiaAKT3;PIK3R5;LEF1;PIK3CB;PIK3R3;IKBKB;RPS6KB2;PML;AKT1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGAV;SGCG;ITGA2;CTNNA3;ITGA7;DSP;CACNG4;CACNA2D1;ITGB3

TCF7L2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7L2 itself. We selected most functions TCF7L2 had, and list some proteins which have the same functions with TCF7L2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingKCNA3;YBX1;GABPA;MYF6;NFAT5;ZFP746;HOXA10;NFATC4;PYDC3
RNA polymerase II core promoter sequence-specific DNA bindingMTF1;YAP1;NFIL3;HOXB3;ZNF277;PAX8;H3F3B;PAX6;SP1
RNA polymerase II repressing transcription factor bindingBBS7;TCERG1;HDAC1;GATA6;STAT3;PPARA;GTF2A2;MKKS;RBPJ
armadillo repeat domain bindingSTRN4;CNOT1;CTNNBIP1;TCF7L2;STRN;CHD8;LEF1;AXIN2;CALCOCO1
beta-catenin bindingPARK2;SMAD7;PSEN1;KDM6B;CDH24;NF2;GLI3;CARM1;APC2
chromatin bindingTLE1;APBB1;MEF2C;CTBP2;PHC1;ARID3A;PELP1;MSL1;HMGB2
gamma-catenin bindingTCF7L2;CTNNA1;DSG1A;LEF1;PTBP3;FER;Fert2;APC;CDH1
nuclear hormone receptor bindingEP300;SMARCD3;CRX;HIF1A;NCOR1;MED1;CTNNB1;Ankar;TCF7L2
protein bindingSNRPC;DYNLL2;BMX;TRIM71;FRMD8;CBX7;DHX8;ZNF34;EEF1E1
protein kinase bindingADAM10;TCTN2;GCSAM;RPS6KA3;STAP1;CD24;ITGB1BP1;SREBF1;CAMK2N2
sequence-specific DNA bindingLHX2;ZNF75D;SPI1A;ETV5A;ETS1;HSF5;PAX6A;CTCFL;NLRP3
transcription factor activity, sequence-specific DNA bindingREL;ZFP746;RORCB;MYT1LA;GATA2B;UBN1;ELF2A;HOXC6;ELF2
transcription factor bindingADD1;DACT2;TRERF1;HYAL1;HDAC8;IFI203;DIP2B;TAF7;SOX8
transcription regulatory region DNA bindingWNT1;CREB3L1;TRP53;XBP1;SOX7;HIVEP3;DDIT3;CTCF;SMARCA2

TCF7L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7L2.

CTNNB1

Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).
  • Q&As
  • Reviews

Q&As (7)

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How does TCF7L2 interact with other transcription factors and signaling molecules? 01/26/2023

TCF7L2 works in concert with other transcription factors and signaling molecules to regulate gene expression.

How do genetic variations in the TCF7L2 gene affect its function and contribute to disease susceptibility? 11/30/2022

Genetic variations in TCF7L2 can significantly impact its function, increasing susceptibility to diabetes and other conditions.

What are the implications of altered TCF7L2 activity in cancer biology? 08/18/2022

Altered TCF7L2 activity is associated with various cancers, affecting tumor growth and metastasis.

What is TCF7L2's function in Wnt signaling pathway and its impact on cell proliferation and differentiation? 01/31/2022

In the Wnt signaling pathway, TCF7L2 regulates genes involved in cell growth, proliferation, and differentiation.

What potential therapeutic strategies could target TCF7L2 in various diseases, including diabetes and cancer? 01/10/2020

Targeting TCF7L2 in therapies could offer new approaches in managing diabetes and certain cancers.

What is the primary role of TCF7L2 in gene regulation and cellular signaling? 01/16/2019

TCF7L2 is a transcription factor that regulates gene expression, playing a crucial role in various cellular processes.

How does TCF7L2 influence the development and progression of diabetes, particularly type 2 diabetes? 02/14/2017

It is strongly linked to type 2 diabetes risk, influencing insulin secretion and glucose metabolism.

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    Exceptional expertise, elevates our research outcomes.

    10/27/2018

      Exemplary service, vital for our studies.

      07/17/2017

        Timely and accurate results, invaluable for research.

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