• Official Full Name
  • transition protein 1 (during histone to protamine replacement)
  • Background
  • Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself;replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 (PubMed;2249851)). IFN-tau is also known as TP-1 (trophoblast protein-1) is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-alpha and IFN-beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE.
  • Synonyms
  • TNP1; transition protein 1 (during histone to protamine replacement); spermatid nuclear transition protein 1; TP-1; STP-1; TP1; Interferon-tau; trophoblast protein-1; Trophoblastin; Antiluteolysin; Trophoblast antiluteolytic protein; OTP; IFNT1; IFNT4; Interferon tau-1; Interferon tau-4
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNP1, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNP1 Protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnp1 Protein, His/GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNP1 Protein
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Trophoblast Protein-1

Protein Function

TNP1 has several biochemical functions, for example, DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNP1 itself. We selected most functions TNP1 had, and list some proteins which have the same functions with TNP1. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein KDM5BA; HIST3H2BB; HOXC13B; POU2F1B; ZNF32; TBX2B; ANG; FAM170A; TSHZ3; TLR8
Function protein binding
Related Protein TK1; SNRPD3; CEP70; GRAP2; FBXO17; PCSK2; XRCC1; CASP2; LIN28A; TSSK1

Interacting Protein

TNP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNP1.