• Official Full Name
  • transition protein 1 (during histone to protamine replacement)
  • Background
  • Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself;replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 (PubMed;2249851)). IFN-tau is also known as TP-1 (trophoblast protein-1) is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-alpha and IFN-beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE.
  • Synonyms
  • TNP1; transition protein 1 (during histone to protamine replacement); spermatid nuclear transition protein 1; TP-1; STP-1; TP1; Interferon-tau; trophoblast protein-1; Trophoblastin; Antiluteolysin; Trophoblast antiluteolytic protein; OTP; IFNT1; IFNT4; Interferon tau-1; Interferon tau-4
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNP1, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNP1 Protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnp1 Protein, His/GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNP1 Protein
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Trophoblast Protein-1