• Official Full Name
  • topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
  • Background
  • This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
  • Synonyms
  • TOPORS; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; retinitis pigmentosa 31 (autosomal dominant) , RP31, topoisomerase I binding, arginine/serine rich; E3 ubiquitin-protein ligase Topors; LUN; TP53BPL; SUMO1-protein E3 lig
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOPORS, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TOPORS Protein, His-tagged

Protein Function

TOPORS has several biochemical functions, for example, DNA binding, DNA topoisomerase binding, SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOPORS itself. We selected most functions TOPORS had, and list some proteins which have the same functions with TOPORS. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein ZNF556; SUPV3L1; ZFP511; HIC2; GTF2A1; SMARCC1; ZFP541; HES7; HMBOX1A; TEAD2
Function DNA topoisomerase binding
Related Protein SETMAR; TOPORS
Function SUMO transferase activity
Function antigen binding
Related Protein PPP2R1A; SLAMF1; MHC1UKA; LAG3; LILRA2; KIR2DL3; TSPAN4; IGLC2; Ighg; Ighg2a
Function ligase activity
Related Protein MUL1; TRIM17; LNX1; TTLL4; UBE4B; ACSM2; IRF2BP1; UBE2I; CBL; HERC4
Function protein binding
Related Protein ACTR6; PSMB9; DTD2; RPS10; FAM126B; NIP7; AKAP7; ANO2; TRPM8; NLRC4
Function ubiquitin protein ligase activity
Related Protein CDK8; MED17; G2E3; RNF121; RNF146; RNF2; UBE2J2; UBE2G1A; UBE2NA; UBE3C
Function ubiquitin-protein transferase activity
Related Protein TSPAN17; UBR1; MIB2; RNF25; UBE2G2; MARCH5; RBCK1; BIRC8; UBE2M; MARCH6
Function zinc ion binding
Related Protein BRD1; ADAM9; RNF181; TRAIP; ZNRF2B; Car8; PARP1; NR1D2; APOBEC3G; GATA5

Interacting Protein

TOPORS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOPORS here. Most of them are supplied by our site. Hope this information will be useful for your research of TOPORS.
TP53; CASP8; Rep78; UBE2L6; Tp53; Rep68; UBE2D1; UBE2D3; UBE2N; UBE2D2; SATB1; SETX; SNIP1; pyrC; UBE2W; UBE2D4; UBE2J1