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TRIM6

Official Full Name

tripartite motif containing 6
Overview

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members.
Synonyms

TRIM6; tripartite motif containing 6; tripartite motif-containing protein 6; RNF89; Ring Finger Protein 89; TRIM 6; Tripartite motif containing protein 6; tripartite motif-containing 6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRIM6-3415H	Recombinant Human TRIM6, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25ug
Human	TRIM6-765HCL	Recombinant Human TRIM6 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TRIM6-3918H	Recombinant Human TRIM6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	TRIM6-17386M	Recombinant Mouse TRIM6 Protein	Mammalian Cell	His		Inquiry
Mouse	TRIM6-9617M-B	Recombinant Mouse TRIM6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Trim6-6661M	Recombinant Mouse Trim6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	TRIM6-9617M	Recombinant Mouse TRIM6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TRIM6 involved in several pathways and played different roles in them. We selected most pathways TRIM6 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine Signaling in Immune system	BST2;IFI35;FRS2B;WDR83;TRIM10;JAK3;CNKSR1;TRIM46;XAF1
Immune System	RAPGEF3;POLR3H;GZMM;EVL;EDAR;LGALS3;LILRB5;DYNC1I1;TNRC5
Interferon Signaling	TRIM29;IRF2;EIF4G2A;TRIM48;TRIM6;TRIM5;ARIH1L;TRIM3;TRIM45
Interferon gamma signaling	TRIM22;IRF4;GBP2;TRIM29;TRIM5;TRIM31;HLA-DQB2;TRIM3;FCGR1B

TRIM6 has several biochemical functions, for example, ligase activity, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM6 itself. We selected most functions TRIM6 had, and list some proteins which have the same functions with TRIM6. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	HECW1B;SH3RF1;PRP19;RLIM;DTX2;RNF126;RNF180;RNF220;TTLL5
molecular_function	GM4220;CRYGM2B;SMG8;CRYGS1;DSCR4;GM996;TSPAN5A;CRYBA1A;TSPAN4B
protein binding	USP18;TFAP4;ATP6V0A1;MOCOS;VPS53;RPP38;ARL16;BCL2A1A;GNL3L
protein binding, bridging	FGA;SPRR1B;TRIM6;BCL3;STX1A;IVL;CUX1;ANK2;TRIM22
protein kinase binding	TPRKB;IRS2;LATS1;PRC1;STAP1;PTPRK;LSM2;PTK2;BCL10
protein tyrosine kinase binding
transcription factor binding	HDAC11;DDIT3;SUFU;PIANP;PDCD11;FLNA;RBL1;KAT2A;HMGB1
ubiquitin protein ligase activity	HECW1B;XIAP;RBX1;TRIM11;RAD18;UBE2V1;MARCH1;TOPORS;MDM2
zinc ion binding	ZZEF1;Car8;C11orf54;BMI1;RNF122;ZNFL1;DDX41;ADH5;CDADC1

TRIM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM6.