• Official Full Name
  • WD repeat domain 11
  • Background
  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
  • Synonyms
  • WDR11; WD repeat domain 11; bromodomain and WD repeat domain containing 2 , BRWD2; WD repeat-containing protein 11; FLJ10506; KIAA1351; Bromodomain and WD repeat containing protein 2; Bromodomain and WD repeat domain containing 2; BRWD2; DR11; WD repeat containing protein 11; WD repeat containing protein 15; WD repeat domain 15; WDR 11; WDR15; WD repeat-containing protein 15; bromodomain and WD repeat-containing protein 2
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human WDR11
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WDR11 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human WDR11 293 Cell Lysate

Protein Function

WDR11 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR11 itself. We selected most functions WDR11 had, and list some proteins which have the same functions with WDR11. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein TRPC4; ARHGEF10; PPP3CB; ATP6V1C1; ADRA2C; PDE6D; HDAC6; CD22; PGBD1; CAMK2B

Interacting Protein

WDR11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR11 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR11.
GABARAPL1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; UBXN7; GABARAPL1

WDR11 Related Articles

Yue, MM; Lv, K; et al. Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit b (eIF3b) to Promote Translation of Transforming Growth Factor beta 1-3 (TGF-beta 1-3). JOURNAL OF BIOLOGICAL CHEMISTRY 289:33971-33983(2014).
Huber, C; Wu, SL; et al. WDR34 Mutations that Cause Short-Rib Polydactyly Syndrome Type III/Severe Asphyxiating Thoracic Dysplasia Reveal a Role for the NF-kappa B Pathway in Cilia. AMERICAN JOURNAL OF HUMAN GENETICS 93:926-931(2013).